HIV / AIDS: CONTRACEPTIVE & HIV PREVENTING VAGINAL RING DISCOVERED,BEING USED TO PREVENT PREGNANCY & HIV

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AN INTRAVAINAL RING HAVING LOADED MEDICINES TENOFOVIR (AN HIV ARV NRIT MEDICINE) AND LEVONORGESTREL (A CONTRACEPTIVE) has been developed by Northwestern University biomedical engineer Patrick Kiser .This is first-of-its-kind intravaginal ring 'reliably delivers' an antiretroviral drug and a contraceptive for months.
The device is designed to protect against HIV and herpes as well as unwanted pregnancy. It will be the first device with the potential to offer this protection to be tested in women.

According to the World Health Organization, 35 million people around the world live with HIV, and 222 million women would like to delay or stop childbearing but are not using any method of contraception.“I suspect women will use the ring primarily for contraception, but they also will benefit from protection against sexually transmitted diseases,” said Kiser, an expert in intravaginal drug delivery. “And for women in the developing world in particular, unwanted pregnancy can have significant health, economic and cultural consequences. We want to motivate women to use this ring.”

The ring, 5.5 centimetres in diameter, is simple yet complex. Kiser and his colleagues worked painstakingly for five years, engineering the three materials that make up the ring and optimizing the device to reliably deliver fixed and efficacious doses of two medicines over a long period of time.the ring is easily inserted in the vagina and stays in place for three months. And because the tenofovir is delivered at the site of transmission, the ring – known as the tenofovir levonorgestrel IVR – utilizes a smaller dose than pills. The levonorgestrel released by the ring is the same drug as that used in certain contraceptive pills and in an intrauterine device.

Tenofovir is taken orally by 3.5 million HIV-infected people worldwide, and it also has been studied as a gel. The drug inhibits HIV and HSV-2 (herpes simplex virus-2) replication in susceptible cells.

Previous studies have demonstrated that antiretroviral drugs can prevent HIV infection, but existing methods for delivering the drug fall short. Pills must be taken daily and require high doses; some women may prefer a longer-lasting method, such as the ring, versus methods used at the time of sex, such as a gel.
The antiretroviral drug section of the ring is made of one kind of polyurethane, and the contraceptive section of the ring is made of another polyurethane. Each material needed to be engineered with the correct diffusion rates, so the encapsulated drug is released into the body at the desired rate, providing the correct dose.

A third polyurethane material between the two sections keeps the drugs separate. All the parts are welded together to complete the ring.