Apart from the deep acting constitutional remedies like Phosphorus, Lycopodium, Pulsatilla, Nux vomica and Sepia, the other remedies that may help in tackling the fatigue are:

Kali phos: This is the chief Biochemic "nerve salt," and is found in the brain cells and nerve fluids, and the intercellular fluids. It is useful for patients with despondency, anxiety, fearfulness, weak memory, mental decay, mental and physical breakdown, neurasthenia, hypochondriasis, hysteria, insomnia, night terrors, irritability, insanity and paralysis. This salt has proved curative in nervousness, neurasthenia, anxiety, depression, brain-fag, loss of memory, sleeplessness, delirium tremens, horrors, dread, epileptic fits, and exhaustion.

Phosphoric acid: This remedy is to nervous debility what iron is to anemia, and it corresponds to that debility arising from continued grief, over- exertion of the mind, sexual excesses or any nervous strain on the body or mind. Indifference, apathy, and torpidity of body and mind characterize the remedy. There is burning in the spine and limbs and the patient is inclined to be drowsy and listless. Any attempt to study causes heaviness in the head and limbs. It suits also young, rapidly growing people, and especially cases of nervous depression from spermatorrhoea.

Gelsemium: A mainstay in this disease. Stupid, dull, unable to concentrate mind; vertigo, dull ache at base of brain. Lacks self-confidence. Sudden emotions bring on diarrhoea or indigestion.

Picric acid: Corresponds well to the brain fag of businessmen who become depressed and wearied from slight fatigue. It is a mental inactivity, with a desire to lie down and rest. The great characteristic is that slight exertion brings on exhaustion and headache, incapacitating for work, and extinguishes that quality which we call grit. Even the slightest mental exertion causes heavy feelings and a sensation of heat. The headache may be frontal or occipital and extended down the spine, in fact, the head symptoms seems to be concentrated in the occiput. Sexual irritability may be a prominent symptom. In the morning there is a tired aching in the lumbar region, the legs are heavy and weak with the soreness of the muscles and joints.

Avena sativa: Has a selective action on brain and nervous system, favorably influencing their nutritive function. Weakness of nerves, tired brain, irritability, gets excited at least thing. Urine has excess of phosphates, history of sexual excesses and occipital headache. Best tonic for debility after exhausting diseases. Nerve tremors of the aged. Sleeplessness in alcoholics. This remedy will calm and strengthen the nerves.