World's first medical networking and resource portal

Articles
Category : All ; Cycle : March 2014
Medical Articles
Mar30
DUODENAL SWITCH (A PUNCH AGAINST OBESITY)
Duodenal switch, one of the most complicated weight loss surgeries, is also known as vertical gastrectomy with duodenal switch, gastric reduction with duodenal switch, biliopancreatic diversion with duodenal switch, DS or BPD-DS. Duodenal switch packs a one -two punch against obesity.It does so, by combining two surgical techniques: restrictive and malabsorptive.The restrictive component involves reducing the size of the stomach.Your bariatric surgeon would divide the stomach vertically and remove more than 85% of it. The stomach that remains is shaped like a banana and can accomodate about 100 to 150 mls or 6 ounces.
Duodenal switch is a variation of another procedure, called biliopancreatic diversion.But the duodenal switch leaves a larger portion of the stomach intact including the pyloric valve, which regulates the release of stomach contents into the small intestine.As the name suggests, duodenal switch also keeps small part of the duodenum in the digestive system.Food mixes with stomach acids, then moves down to the duodenum, where they mix with bile from the gall bladder and digestive juices from the pancreas. Malabsorptive surgeries restrict the amount of calories and nutrients that the body absorbs.The malabsorptive component of duodenal switch surgery involves rearranging the small intestine to seperate the flow of food from the flow of bile and pancreatic juice.The food and the digestive juices interact only in the last 18 to 24 inches of the intestine, allowing malabsorption. Unlike the restrictive part of the surgery, the intestinal bypass part of the duodenal switch, is partially reversible, if the patient experiences malabsorptive complications.With the duodenal switch, you consume less food than normal, but it is still more than with other weight loss surgeries.Even this amount of food cannot be digested normally, so a large portion of the food passes undigested through the shortened intestine, thereby causing weight loss in the morbidly obese.This surgery is also done laparoscopically.


Category (Cosmetic Surgery)  |   Views (20413)  |  User Rating
Rate It


Mar25
DEMAND OF A MODERN WOMAN FROM A MODERN MAN -by prof.drram,hiv/aids & sex specialist
DEMAND OF A MODERN WOMAN FROM A MODERN MAN
PROF.DRRAM ,HIV/AIDS,SEX DIS.,SEX WEAK.& ABORTION SPECIALIST
profdrram@gmail.com,+917838059592,+919832025033,DELHI �NCR,IND
HIV/ AIDS,CANCER LATEST MEDICINES AVAILABLE AT CHEAP RATE.
FOLLOW ON FACE BOOK:www.facebook.com/drramkumar
FOLLOW ON TWITTER:www.twitter.com/profdrram
.
In a brief conversation, a man asked a woman he was pursuing the question: �What kind of man are you looking for?�
She sat quietly for a moment before looking him in the eye & asking, �Do you really want to know?� Reluctantly, he said,�Yes.�
She began to expound�
�As a woman in this day & age, I am in a position to ask a man what can you do for me that I can�t do for myself? I pay my own bills. I take care of my household without the help of any man�or woman for that matter. I am in the position to ask, �What can you bring to the table?��
The man looked at her. Clearly he thought that she was referring to money.
She quickly corrected his thought & stated, �I am not referring to money. I need something more. I need a man who is striving for excellence in every aspect of life.� He sat back in his chair, folded his arms, & asked her to explain.
She said, �I need someone who is striving for excellence mentally because I need conversation & mental stimulation. I don�t need a simple-minded man.
I need someone who is striving for excellence spiritually because I don�t need to be unequally yoked�believers mixed with unbelievers is a recipe for disaster.
I need a man who is striving for excellence financially because I don�t need a financial burden.
I need someone who is sensitive enough to understand what I go through as a woman, but strong enough to keep me grounded.
I need someone who has integrity in dealing with relationships. Lies and game-playing are not my idea of a strong man.
I need a man who is family-oriented. One who can be the leader and provider to the lives entrusted to him by God.
I need someone whom I can respect. In order to be submissive, I must respect him.
I cannot be submissive to a man who isn�t taking care of his business. I have no problem being submissive�he just has to be worthy.
And by the way, I am not looking for him�He will find me. He will recognize himself in me. Hey may not be able to explain the connection, but he will always be drawn to me. God made woman to be a help-mate for man. I can�t help a man if he can�t help himself.�
When she finished her spill, she looked at him.
He sat there with a puzzled look on his face. He said,�You are asking a lot.�
She replied, �I�m worth a lot�.


Category (Fertility, Pregnancy & Birth)  |   Views (7571)  |  User Rating
Rate It


Mar25
HIV : AIDS : FAMILY PLANNING IS A MUST FOR HIV COUPLE -DANGER OF SPREADING TO INNOCENT CHILDREN IS A KNOWN CRIME
HIV : AIDS : FAMILY PLANNING IS A MUST FOR HIV COUPLE -DANGER OF SPREADING TO INNOCENT CHILDREN IS A KNOWN CRIME
PROF.DRRAM ,HIV/AIDS,SEX DIS.,SEX WEAK.& ABORTION SPECIALIST
profdrram@gmail.com,+917838059592,+919832025033,DELHI �NCR,IND
HIV/ AIDS,CANCER LATEST MEDICINES AVAILABLE AT CHEAP RATE.
FOLLOW ON FACE BOOK:www.facebook.com/drramkumar
FOLLOW ON TWITTER:www.twitter.com/profdrram
.
WE should try our best to educate every hiv/aids persons if living in family that they should take all precutions themselves that this doisease doesnot reach their life parner(using condom during sex,sex is not a bar with negative partner but condom is a must even when viral load is minimum except 1-2 times sex allowed without condom for pregnancy under strict medical guide ) use all method of avoiding contamination of their blood,semen,body fluid like saliva,spits urine ,stool leakage of fluid from brain,cut injury from any where,sputum but not tears and sweat to mix with negative meber at home particularly children and family members or person at office or working place and health staff giving them service,never hide your disease,there is no shame no stigma,it is a disease it happened to you and can happen to me or any body .
Second if 1-2 child born then they should undergo vasectomy or tubectomy permannantly to avoid further pregnancy.if not interested in permannant one then woman can use pills or IUCD insersation .simple sex during non ovulation period or sperm ejaculation out side or spermicide or vaginal spermicide jelly is not that protective one.
Sex with condom is amust as if two hiv positive persons meet their genotype of virus may be different and a new virus genotype in one person and vice versa.so avoid sex without condom even with life partner what to talk of sex with stanger where condom is a must.
never transfuse blood to any person,never share needle,never donate blood or any other organ.


Category (General Medicine)  |   Views (7963)  |  User Rating
Rate It


Mar24
TRUE SELF AND NAMASMARAN: DR. SHRINIWAS KASHALIKAR
TRUE SELF AND NAMASMARAN: DR. SHRINIWAS KASHALIKAR

Student:
Sir! What is true self?
Teacher:
When we refer to self; it usually embodies and connotes a mixture of instincts, feelings, thoughts and vision, associated with the metabolic reactions, hormonal interactions and effects of neurotransmitters. All these interact continuously with the environment (The environment may be internal or external. Further; it may be; physical, chemical, biological, psychological, social, cultural or political. When it is characterized by people in the process of realizing true self; it is called spiritual environment). Thus; self with specific characteristics is recognized as a person; and said to be born and dead; distinguishing it from the body. The biographies do not describe merely the body; of an individual; but describe in details all above!
An object with three dimensions has a beginning, an end, a form and an identity. The space, which occupies; the inside and outside of that object; has a beginning and end. It has a form and an identity related to the object which it occupies from within and from outside.

Further; the time, which occupies a beginning, existence and end of an object; has also the identity of that object! For example; the time characterizes a house; as a 50 year old house! The period has an identity. The time that occupies the birth, life and death of an individual also has an identity. We call it the life of an individual.

Further; an individual human consciousness is associated the matter, the interactions, the energies, and the space and time; occupying all these! with
Self is associated with all above and it has a distinct identity.

True self is beyond all that has been referred to above! It is inside as well as outside. Our final destination is this true self. At one time or another; every one inevitably gets dissolved in the true self. Here the separate identity is dissolved in the cosmic consciousness and we lose separate and shackling existence. This is God; described with either no attributes or infinite attributes!
Student:
How to identify this true self?
Teacher:
The true self is the final and supreme controller. Since it has no form, no characteristics and no attributes, by which we can identify Him! However; He has descended in the consciousness of few; as NAMA and enthralled them with His attraction (ARTA, JIJNYASU, ARTHARTHEE, and JNANEE), remembrance (NAMASMARAN), orientation (ANUSANDHAN) and merger (MOKSHA)! Following them is the way of identifying and merging with true self!


Category (Psychology, Stress & Mental Health)  |   Views (6427)  |  User Rating
Rate It


Mar11
HIV vaccine development necessary for a durable end to AIDS / HIV
HIV vaccine development necessary for a durable end to AIDS / HIV

PROF.DRRAM ,HIV/AIDS,SEX DIS.,SEX WEAK.& ABORTION SPECIALIST
profdrram@gmail.com,+917838059592,+919832025033,DELHI �NCR,IND
HIV/ AIDS,CANCER LATEST MEDICINES AVAILABLE AT CHEAP RATE.
FOLLOW ON FACE BOOK:www.facebook.com/drramkumar
FOLLOW ON TWITTER:www.twitter.com/profdrram
.
Broader global access to lifesaving antiretroviral therapies and wider implementation of proven HIV prevention strategies could potentially control and perhaps end the HIV/AIDS pandemic. However, a safe and at least moderately effective HIV vaccine is needed to reach this goal more expeditiously and in a more sustainable way, according to a new commentary from Anthony S. Fauci, M.D., director of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and colleague Hilary D. Marston, M.D., M.P.H.

In the piece, the authors note that behavioral, cultural and legal factors have hindered HIV prevention and treatment efforts and explain why those factors necessitate the development of an HIV vaccine. Although attempts to develop a vaccine have so far proven disappointing, recent advances offer encouraging areas for HIV vaccine researchers to pursue, according to the authors. Notably, the discovery of naturally occurring broadly neutralizing antibodies against HIV and studies of their stimulation in infected individuals have opened new avenues in vaccine development. Using improved understanding of those antibodies and the specific sites on HIV to which they bind, the natural process of antibody evolution could be replicated and greatly expedited allowing protection against initial infection. Significant advances also have been made in understanding T-cell responses that may be important to vaccine-induced immunity against HIV.

The authors conclude that "the HIV prevention community should hold fast to its commitment to vaccine science. Ultimately, we believe, the only guarantee of a sustained end of the AIDS pandemic lies in a combination of nonvaccine prevention methods and the development and deployment of a safe and sufficiently effective HIV vaccine."


Category (Sexuality & Venereal Disorders)  |   Views (5047)  |  User Rating
Rate It


Mar11
AIDS / HIV & HEPATITIS C INFECTION: RECENT TREATMENT MODULE OF TREATING HIV AND HEPATITIS TOGETHER WITH SOFOSBUVIR
AIDS / HIV & HEPATITIS C INFECTION: RECENT TREATMENT MODULE OF TREATING HIV AND HEPATITIS TOGETHER WITH SOFOSBUVIR

PROF.DRRAM ,HIV/AIDS,SEX DIS.,SEX WEAK.& ABORTION SPECIALIST
profdrram@gmail.com,+917838059592,+919832025033,DELHI �NCR,IND
HIV/ AIDS,CANCER LATEST MEDICINES AVAILABLE AT CHEAP RATE.
FOLLOW ON FACE BOOK:www.facebook.com/drramkumar
FOLLOW ON TWITTER:www.twitter.com/profdrram
.
Hepatitic C is a silent infection like HIv and is common with many patients of hHiv particualrly those are IV DRUG USER OR BLOOD CONTAMINATED.WITH HEPATITIS C HIV MUST BE TREATED FIRST AS START ANTI HIV TREATMENT OR ARV MEDICINES FIRST KEEP VIRAL LOAD OF HIV LOW AND CD4 COUNT MORE FOR BETTER RESULTFOR HCV CURE.
Hepatitis c produce cirrhosis of liver and liver cancer if not treated,we decide to treat it when we see that Liver function of patient deteriorates,Features of cirrhosis like Pedal Oedema,Black spots,Dilated abdominal Veins,Piles or oesophageal varices with Ascites or fluid in abdome with splenomegaly starts and cirrhosis confirmed by either Biopsy or Fibroscan or Usg or we see features of cancer then we resect this liver and transplant new one and with it we treat hepatitis c too.
so,if liver enzymes alters or fetures of cirrhosis starts of if HCV viral load IU/ML OR COPIES/ML(1IU/ML=7COPIES/ML) seen in good concentration and patient opt for therapy as if treatment taken completed than unlike HIV,HCV is curable after 12-24 wks now with sobosfuvir and previously 48 wks without sofosbuvir SVR (SUSTAINED VIRAL RESPONSE) OR VIRAL LOAD ZERO OF HCV IS POSSIBLE
we see that what type of HCV it is as Genotype 1 or 1A or 1B or type 2,Type 3 or type 4 .Genotype HCV 1A and type 4 are hard to treat they need peglyated Interferon with Ribvarin for 24-48 wks with Bocprevir and telaprevir either if alone or with HIV but with Sofosbuvir now it is found that interferon-free regimen of sofosbuvir plus ribavirin for 24 weeks led to sustained response in three-quarters of previously untreated people with genotype 1 hepatitis C and HIV co-infection in the PHOTON-1 study,and 12 wks therapy for type 2 but for type 3 also a course of 24 wks needed like type 1A not shorter 12 wks as for type 2 as we think type 2 and type 3 are easy responders.according to a report at the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) this week in Boston.

People with HIV/HCV co-infection experience more rapid liver disease progression and do not respond as well to interferon-based therapy as people with hepatitis C alone. Direct-acting antivirals like sofosfuvir or SOVALIDI or PREVIOUS KNOWN GS-7977 that target different steps of the HCV lifecycle offer the prospect of shorter treatment, fewer side-effects and higher cure rates for both HCV mono-infected and HIV/HCV co-infected patients.In less advanced case or type 2 or type 3 simprenavir can also be tried.Previous to this costly Sofosbuvir (ruprees 50000 dollars for one month )but pegylated Interferon is very toxic and cannot be easily tolerated by every pateient previously we were using INTERFERON ALPHA 2a OR ALPHA 2b which dose was twice a week but now pegylated once a week injection,Ribarin in dose 0f 1000-1200 mg as per body weight and Sofosbuvir 400 mg once a day only.


Category (General Medicine)  |   Views (4088)  |  User Rating
Rate It


Mar11
AIDS/ HIV HIGH PREVALENCE IN INDIA :UN DECLARATION ZERO HIV / ZERO DISCRIMINATION BY 2015
AIDS:UN DECLARATION ZERO HIV / ZERO DISCRIMINATION BY 2015

PROF.DRRAM ,HIV/AIDS,SEX DIS.,SEX WEAK.& ABORTION SPECIALIST
profdrram@gmail.com,+917838059592,+919832025033,DELHI �NCR,IND
HIV/ AIDS,CANCER LATEST MEDICINES AVAILABLE AT CHEAP RATE.
FOLLOW ON FACE BOOK:www.facebook.com/drramkumar
FOLLOW ON TWITTER:www.twitter.com/profdrram
.

There are 22 priority countries; they have the highest number of pregnant women living with HIV, as recognised in the �Global Plan towards the elimination of new HIV infections among children by 2015 and keeping their mothers alive�.Global plan was formulated by 110 countries of World in UN HQ by formulating 10 TARGETS ,THE GOAL TO BE COMPLETED BY 2015 WITH YEARLY SURVEILLANCE AND MONITORING OF PROGRAMME AND ITS SUCCESS AND HINDRANCE to combat hiv/aids spread,contamination and new cases to promote zero tolernce for hiv/aids,no new cases or ZERO HIV NEW INFECTION AND DEATH DUE TO AIDS by good funding of screening every person for HIV/AIDS and providing primary and secondary treatment for every infected person in countries like india,and other sian countries and countries of AFRICA AND LATIN AMERICA and to extend insurance sector to HIV /AIDS IN USA BY PRESIDENT PROFAR PROGRAMME,ZERO DISCRIMINATION OR STIGMA for HIV LIKE A BILL IN UPPER HOUSE IN INDIA to punish those who discriminate HIV /AIDS.
These 22 countries are: Angola, Botswana, Burundi, Cameroon, Chad, C�te d�Ivoire, Democratic Republic of the Congo, Ethiopia, Ghana, India, Kenya, Lesotho, Malawi, Mozambique, Namibia, Nigeria, South Africa, Swaziland, Uganda, United Republic of Tanzania, Zambia, and Zimbabwe. India is the only country not in Africa.
10 TARGETS SETS UNIVERSALLY TO COMBAT HIV/AIDS WITH SPECIAL FOCUS ON ABOVE 22 COUNTRIES ARE AS FOLLOWS:-----.

1.Reduce sexual transmission of HIV by 50% by 2015
2.Halve the transmission of HIV among people who inject drugs by 2015
3.Eliminate HIV infections among children and reduce maternal deaths
4.Reach 15 million people living with HIV with lifesaving antiretroviral treatment by 2015
5.Halve tuberculosis deaths among people living with HIV by 2015
6.Close the global AIDS resource gap
7.Eliminate gender inequalities and gender-based abuse and violence and increase the capacity of women and girls to protect themselves from HIV
8.Eliminate HIV-related stigma, discrimination, punitive laws and practices
9..Eliminate HIV-related restrictions on entry, stay and residence
10.Strengthen HIV integration � with Sikkim Aids Empl Assocn and 15 others. (4 photos)


Category (General Medicine)  |   Views (3861)  |  User Rating
Rate It


Mar10
HIV / AIDS: CONTRACEPTIVE & HIV PREVENTING VAGINAL RING DISCOVERED,BEING USED TO PREVENT PREGNANCY & HIV
HIV / AIDS: CONTRACEPTIVE & HIV PREVENTING VAGINAL RING DISCOVERED,BEING USED TO PREVENT PREGNANCY & HIV

PROF.DRRAM ,HIV/AIDS,SEX DIS.,SEX WEAK.& ABORTION SPECIALIST
profdrram@gmail.com,+917838059592,+919832025033,DELHI �NCR,IND
HIV/ AIDS,CANCER LATEST MEDICINES AVAILABLE AT CHEAP RATE.
FOLLOW ON FACE BOOK:www.facebook.com/drramkumar
FOLLOW ON TWITTER:www.twitter.com/profdrram

AN INTRAVAINAL RING HAVING LOADED MEDICINES TENOFOVIR (AN HIV ARV NRIT MEDICINE) AND LEVONORGESTREL (A CONTRACEPTIVE) has been developed by Northwestern University biomedical engineer Patrick Kiser .This is first-of-its-kind intravaginal ring 'reliably delivers' an antiretroviral drug and a contraceptive for months.
The device is designed to protect against HIV and herpes as well as unwanted pregnancy. It will be the first device with the potential to offer this protection to be tested in women.

According to the World Health Organization, 35 million people around the world live with HIV, and 222 million women would like to delay or stop childbearing but are not using any method of contraception.�I suspect women will use the ring primarily for contraception, but they also will benefit from protection against sexually transmitted diseases,� said Kiser, an expert in intravaginal drug delivery. �And for women in the developing world in particular, unwanted pregnancy can have significant health, economic and cultural consequences. We want to motivate women to use this ring.�

The ring, 5.5 centimetres in diameter, is simple yet complex. Kiser and his colleagues worked painstakingly for five years, engineering the three materials that make up the ring and optimizing the device to reliably deliver fixed and efficacious doses of two medicines over a long period of time.the ring is easily inserted in the vagina and stays in place for three months. And because the tenofovir is delivered at the site of transmission, the ring � known as the tenofovir levonorgestrel IVR � utilizes a smaller dose than pills. The levonorgestrel released by the ring is the same drug as that used in certain contraceptive pills and in an intrauterine device.

Tenofovir is taken orally by 3.5 million HIV-infected people worldwide, and it also has been studied as a gel. The drug inhibits HIV and HSV-2 (herpes simplex virus-2) replication in susceptible cells.

Previous studies have demonstrated that antiretroviral drugs can prevent HIV infection, but existing methods for delivering the drug fall short. Pills must be taken daily and require high doses; some women may prefer a longer-lasting method, such as the ring, versus methods used at the time of sex, such as a gel.
The antiretroviral drug section of the ring is made of one kind of polyurethane, and the contraceptive section of the ring is made of another polyurethane. Each material needed to be engineered with the correct diffusion rates, so the encapsulated drug is released into the body at the desired rate, providing the correct dose.

A third polyurethane material between the two sections keeps the drugs separate. All the parts are welded together to complete the ring.


Category (General Medicine)  |   Views (3833)  |  User Rating
Rate It


Mar10
HIV /AIDS: ARV MEDICINES : SOME TRUTHS & MYTHS OF TREATMENT FOR HIV /AIDS PATIENTS FOR BETTER ADHERANCE & CURE
HIV /AIDS: ARV MEDICINES : SOME TRUTHS & MYTHS OF TREATMENT FOR HIV /AIDS PATIENTS FOR BETTER ADHERANCE & CURE

PROF.DRRAM ,HIV/AIDS,SEX DIS.,SEX WEAK.& ABORTION SPECIALIST
profdrram@gmail.com,+917838059592,+919832025033,DELHI �NCR,IND
HIV/ AIDS,CANCER LATEST MEDICINES AVAILABLE AT CHEAP RATE.
FOLLOW ON FACE BOOK:www.facebook.com/drramkumar
FOLLOW ON TWITTER:www.twitter.com/profdrram

Antiretroviral therapy -- or ART -- A COMBINATION OF 3-4 DRUGS COMPRISING OF EITHER NRIT OR NNRITS WITH PROTESE INHIBITOR WITH FUSION OR INTEGRASE INHIBITOR OR RECEPTOR BLOCKE revolutionized HIV treatment in the past few decades. And newer improvements, like one-pill-a-day drugs,or injections once a quarter as i wrote in my last article,are making life with HIV easier and safer.
Like chronic disease as hypertension,Diabetes,thyroid or Kidney or cancer we have to take this medicines regularly without any fail and if we do so we shall get Viral load or quantity of virus in our body decreses and our defense cell cd4 population rises and we live a normal life and no opputunistic infections like tb,diarrhoea,skin rashes,ulcers or mouth lesion or fungal infection attacks us.decision to which drug to be used is a complcated one and only an experienced doctor keeping details of type of patients,exposures and presence of infections and general condition of patients and personal history of pt and economical conditions all gives input to DOCTOR TO SELECT DRUG ON EXPERIENCE and DOCTORCHANGES IT IF RESPONSE IS NOT COMING OR ADD SOME MORE IF OPPUTUNISTIC OR OTHER SYMPTOS DEVELOP.
SO SELF MEDICATION OR MEDICATION ONSIMPLE NET OR TELEPHONIC ADVICE ARE DANGEROUS AND SHOULD BE NEVER TAKEN.TILL NOW ALTERNATIVE HERBAL MEDICINES EFFICACY IS NOT PROOVED SO NEVER TRUST THEM AND AVOID THEM EXCEPT SOME VITMINS,FOOD SUPPLEMENTS AND EXCERCISES.

5 Things to Know About HIV Medications;--
There are lots of myths and stale, outdated information about HIV treatment. Here are five things you should know about ART.
It's easier to take than it used to be. A lot of people with HIV just take one pill once a day. That's it. That one combination pill -- Atripla, Complera, or Stribild -- packs in all the different active ingredients you need. Most people don't need the "cocktails" with complicated dosing schedules anymore.
You have lots of options. Some people need drug combinations. There are six classes of antiretroviral drugs for HIV and more than 30 drugs. If one doesn't work or causes side effects, the doctor has many other choices.
Medications work for a long time. People used to worry that their drugs would stop working after a while and that they'd have to keep switching to new ones. That's not really a risk now. "As long as you keep taking your medications, the same treatment can work for decades," Hare says.
Drugs have fewer side effects. While specific side effects depend on the drug, HIV treatment is much safer and easier to tolerate than it used to be. For most people, side effects -- like upset stomach and diarrhea -- are minor and often go away. Long-term risks include cholesterol problems and weakened bones. But even so, the risks of treatment are much lower than the risks of not getting it, Hare says.
You may start taking medication as soon as you're diagnosed. Many experts believe that the sooner you start treatment, the better. However, some doctors prefer to wait until your CD4 count, a measure of some immune cells, drops to a certain point before starting treatment. See what your doctor recommends.


Category (General Medicine)  |   Views (3649)  |  User Rating
Rate It


Mar09
HIV AIDS: LONG ACTIVE ONCE IN A QUARTER MEDICINE IS ON WAY: BETTER COMPLIANCE AND ADHERANCE LESS SIDE EFFECTS
HIV AIDS: LONG ACTIVE ONCE INA QUARTER MEDICINE IS ON WAY :

PROF.DRRAM ,HIV/AIDS,SEX DIS.,SEX WEAK.& ABORTION SPECIALIST
profdrram@gmail.com,+917838059592,+919832025033,DELHI �NCR,IND HIV/ AIDS,CANCER LATEST MEDICINES AVAILABLE AT CHEAP RATE.
FOLLOW ON FACE BOOK:www.facebook.com/drramkumar
FOLLOW ON TWITTER:www.twitter.com/profdrram

A long-acting, injectable HIV drug could potentially protect people from infection with the AIDS virus for up to three months, new animal studies suggest.The experimental drug, called GSK744, protected macaque monkeys from repeated attempts to infect the animals with a hybrid simian/human AIDS virus called SHIV, scientists said.

GSK744 is a reformulated, long-acting version of an HIV drug known as dolutegravir (Tivicay), which has been approved by the U.S. Food and Drug Administration for treatment in people who have already been infected with HIV and is now used in many combination as primary or secondry drug in USA AND UK but not IN OUR ART CENTRES .these are less toxic and having less side effects and reisitant to virus is almost unknown.

While GSK744 hasn't been tested on humans, doctors hope that it will lead to a medication that could effectively protect people against HIV infection, mostly because it would only need to be administered on a quarterly basis. However, findings from animal studies often don't hold up in human trials.

Such a long-lasting drug would help overcome one of the major problems with current medications that attempt to protect against HIV infection -- the ability of people to take their medication on a daily basis.

"Some of the really good pre-exposure prophylaxis treatments have not been effective, mainly because people don't take the drug," said Dr. Anthony Fauci, director of the U.S. National Institute of Allergy and Infectious Diseases. "The major stumbling block the field has experienced has been the lack of adherence. It's not because the drugs don't work. It's because people don't take them as directed."

Researchers expect to launch human trials for GSK744 within a matter of months, said study author Chasity Andrews, a scientist with the Aaron Diamond AIDS Research Center at Rockefeller University in New York City.

GSK744 is in a class of antiretroviral drugs called integrase inhibitors. These medications block HIV from inserting its genetic material into the body's immune cells.

GSK744 is different in that it crystallizes in the bloodstream, allowing a slow, steady release of the medicine over time, the Rockefeller researchers explained.

Their findings are published online March 6 in the journal Science. The Rockefeller study, and similar results from a study conducted by researchers at the U.S. Centers for Disease Control and Prevention, were presented Tuesday at the annual Conference on Retroviruses and Opportunistic Infections in Boston, according to published reports.

The medication levels that protected the monkeys translate to doses that could sustain human protection for 12 weeks to 16 weeks, Andrews said.

Effective protection against HIV is necessary to fight the spread of AIDS. There were 2.3 million new HIV infections globally in 2012, the researchers noted in background material, with more than 35.3 million people already infected. � with AidsControl Empl India and 19 others.


Category (General Medicine)  |   Views (3466)  |  User Rating
Rate It


Browse Archive