A 4 year old boy presented with unilateral non progressive, non pruritic black discoloration of right arm,
axilla and trunk since birth. There was no history of seizure or developmental delay. There was no family
history of seizure disorder or similar lesions. Examination of the child revealed verrucous elevated papules and
plaques over right arm, axilla and trunk dark blue in color with well defined margins (Fig.1). Other systems
were normal. Patient was started on topical vitamin D analogue Calcipotriol and oral isotretion (0.5 mg/ kg/
day) with advice of regular follow up.

What is the diagnosis?
Unilateral Verrucous Epidermal Nevus. Epidermal nevi are hamartomas that are characterized by hyperplasia
of the epidermis and adnexal structures. These have been estimated to occur in 1: 1000 live births, affecting
the sexes equally. They occur sporadically, however familial cases have been reported. An estimated one
third of individuals with epidermal nevi have involvement of other organ systems; hence, this condition is
considered to be an epidermal nevus syndrome (1). Typically, epidermal nevi are present at birth or early
infancy but have been described to appear in puberty (2). Verrucous epidermal nevi occur in circumscribed
patches or more often, in linear streaks or whorls following Blaschko`s lines (3). The lesions typically occur
on the trunk or extremities, but may also occur on the face and neck (1). The lesions may vary from skin
colored to brown. Histologically, keratinocytic, or verrucous epidermal nevi are characterized by acanthosis,
orthohyperkeratosis, papillomatosis and an expanded papillary dermis which is sharply demarcated from the
surrounding normal skin. No ideal treatment is yet available, the topical treatments such as combined therapy
of retinoic acid and 5-fluorouracil, Vitamin D analogues (Calcipotriol), dithranol, occlusive topical steroids,
chemical peels and podophyllin may improve the keratotic surface however they are always associated with
high rate of recurrence (4). Other treatment includes laser ablation with variable results.
Acknowledgment: Author thanks Dr Amar Kant Jha, Associate Professor, Department of Dermatology, Patna
Medical College, Patna for his help in managing the case.
Funding: None
Competing interests: None.
REFERENCES:
1. Losee JE, Serletti JM, Pennino RP. Epidermal nevus syndrome: a review and case report. Ann Plast Surg. 1999 ;
43:211-4
2. Rogers M, McCrossin I, Commens C. Epidermal nevi and the epidermal nevus syndrome. A review of 131 cases. J Am
Acad Dermatol. 1989; 20: 476-488
3. Bolognia JL, Orlow SJ, Glick SA. Lines of Blaschko. J Am Acad Dermatol. 1994; 31(2 Pt 1):157-190` quiz 190-192.
4. Fox BJ, Lapins NA. Comparison of treatment modalities for epidermal nevus: a case report and review. J Dermatol Surg
Oncol. 1983, 9: 879-885
E-published: May 2011 . Art#33

MULJIBHAI PATEL UROLOGICAL HOSPITAL, NADIAD

Nadiad Kidney Hospital becomes the first hospital in India to install the ‘Prostate HistoScanning’

Muljibhai Patel Urological Hospital, Nadiad has become the first hospital in India to introduce the state-of-the-art ‘Prostate Histoscanning’. To take care of the increasing number of uro cancer patients, in 2010, the hospital had set up a full-fledged ‘Rohit J Patel Department of Uro-oncology’. MPUH was the first hospital in India to acquire the Robotic HIFU for non-surgical, least invasive treatment of prostate cancer in the elderly. The hospital started laparoscopic radical prostatectomy in 2004 and have performed more than 100 such procedures for localized carcinoma prostate. MPUH was also the first hospital in western India to introduce da Vinci Si Robotic-assisted surgery for kidney, prostate and bladder cancer in 2010.

Prostate HistoScanning is a proprietary tissue characterisation technology developed to differentiate, characterise and visualise prostate tissue, based on the analysis of backscattered ultrasound. It is a unique ultrasound application to aid: Treatment selection, Individual treatment planning, and Triaging patients for active surveillance. It also provides a complete analytic prostate imaging solution for visual reassurance: Accessible and user-friendly solution within the clinic, Provides high quality 3D visualisation of the prostate gland; up to 895 frames per scan, Provides accurate localisation and extent of differentiated tissue suspected to be cancer in less than 5 minutes extra ultrasound exam time.
With the introduction of Prostate HistoScanning, the doctors at MPUH are better equipped to diagnose and treat prostate cancer.

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