TITLE-SERUM LIPID PROFILE IN FALCIPARUM MALARIA &  IT’S PROGNOSTIC SIGNIFICANCE
AUTHORS—B.K.BARIK, S.GURU, B.N.PATNAIK,P.DAS


INSTITUTE—I M S & SUM HOSPITAL, BHUBANESWAR
MATERIALS & METHODS---

The present study was conducted among 30 cases of complicated & 30 case of uncomplicated malaria admitted to this Hospital during the period from January 2009 to December 2010.
AIM & OBJECTIVE—



To find out changes in Serum lipid profile in Falciparum Malaria & correlate it with prognostic significance

A control group of 45 cases were taken matching the criterias as far as possible from healthy volunteers.

Cases of DM, CKD &Hypertension were excluded from the study.
Contd….

Serum lipid profile(Total cholesterol, Triglyceride, HDL, LDL, VLDL) were estimated on admission, after diagnosis after 8 hours over night fast.
The method used was Dual Precipitation Method.

All lipid parameters ere repeated after 7 days of treatment of all cases.

Besides all clinical examination & other routine laboratory investigations were done.
OBSERVATION
Age & Sex distribution in Cases and Control
DISCUSSION-

In our study cases belonged to younger group with male predominance.

In complicated cases Renal, Hepatic & CNS involvement was predominant.

In complicated cases TG& VLDL was high that decreased after 7 days of treatment comparing uncomplicated cases.

High TG & VLDL was associated with hepatic & renal dysfunction.
CONCLUSION-

Serum TG can be considered most important prognostic indicator with many variations in lipid fractions.

Serum HDL is also good indicator with low sensitivity but high specificity.

Serum TG level returns to baseline after 7 days indicating response assesment