Periodontitis is an inflammatory disease that causes destruction of tooth supporting tissues, characterized by multifactorial etiology with pathogenic bacteria being the primary etiologic agents that dwells the subgingival area. Local drug delivery system consists of antimicrobial dosages that produces more constant and prolonged concentration profiles within the subgingival tissue and provides better access into the periodontal pockets. It addresses the critical distress of exposing the patient to adverse effects of systemic administration. This article reviews the literature and presents novel trends such as osteoblast activators, growth factors, and herbal products in the local drug delivery system.