Background Because all-ceramic crowns are more aesthetic and biocompatible than metal-ceramic crowns, they have grown in popularity among patients and dentists. Poor finish line layout can result in restoration margin fracturing, hence, finish line arrangement is critical to maintaining the restoration's marginal integrity. The goal of this in-vitro study is to evaluate zirconia's resistance to fracture (Cercon) ceramic restorations with three marginal designs (no finish line, heavy chamfer, and shoulder). This study is important in contributing to the ongoing debate about the optimal finish line design for zirconia restorations. Methodology Three different finish lines, namely, biologically oriented preparation technique (BOPT) with a marginal width of less than 0.3 mm, heavy chamfer with a marginal width of up to 0.3 mm, and shoulder with a marginal width greater than 0.3 mm, were made on 10 extracted maxillary first premolar tooth to make 30 epoxy resin dies on which zirconia (Cercon) coping was done using CAD/CAM technology, and marginal discrepancies were measured using a three-dimensional scanner. All the copings were affixed to their respective dies using GIC luting cement, and fracture resistance was measured using a digital universal testing machine. Results The Kruskal-Wallis test revealed that the mean fracture resistance was more in the heavy chamfer finish line, followed by the no finish line (BOPT) and the shoulder finish line. No statistically significant difference was seen between the no finish line and the heavy chamfer finish line. There was a significant difference between the heavy chamfer and shoulder finish lines (p = 0.004). Conclusions To increase the biomechanical performance of posterior single zirconia restorations, heavy chamfer margins are indicated.