A novel, subdermal implant delivering potent antiretroviral drugs shows extreme promise in stopping the spread of HIV, researchers report. Scientists Dr Baum say that they have developed a matchstick size implant, similar to a contraceptive hormonal implant first used in 1993 to prevent egg release,that successfully delivers a controlled, sustained release of ARV drugs up to 40 days in dogs with no adverse side effects. 
It is easily inserted and removed and provides sustained release of the potent prodrug tenofovir alafenamide, which is roughly ten times more potent against HIV than tenofovir disoproxil fumarate, another tenofovir prodrug that has been shown to prevent sexually transmitted HIV when used as a pre-exposure prophylaxis," adds Dr. Baum. "We are very pleased with the results of our preliminary studies and are working diligently to develop a subdermal implant for HIV prevention that will remain effective for a full 12 months."
Daily administration of oral or topical ARV drugs to HIV negative individuals in vulnerable populations is a promising strategy for HIV prevention. However, adherence to the dosing regimen has emerged as a critical factor in determining effective outcomes in clinical trials.

"This novel device will revolutionize how we treat or prevent HIV/AIDS as it delivers powerful HIV-stopping drugs and eliminates one of the key obstacles in HIV/AIDS prevention -- adherence to proper dosing regimens," he adds.

Medical practitioners and scientists acknowledge that one of the main drawbacks in current medical treatments is the problem of adherence. "It's unfortunate, but patients do not always follow the dosing instructions as prescribed," says Dr. Baum. "In clinical trials erratic administration of drugs has led to highly variable efficacy outcomes. That's what peaked our interest in the possible use of a subdermal implant for the prevention of HIV," suggests Dr. Baum.