HIV drug PrEP not linked to greater risk for depression in homo or hetero

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A new paper out of the iPrEx study--a randomized, placebo-controlled trial of daily oral HIV pre-exposure prophylaxis (PrEP) in men and transgender women who have sex with men--reported no link between taking Truvada for oral PrEP and experiencing depression as shown in some previous studies.
The current study, published in AIDS and Behavior, systematically examined whether there was a causative link between Truvada and depression. Comparing scores on a depression and a suicidal ideation scale administered during the study, the researchers found there was no difference in depression or suicidality between participants who received Truvada or placebo. There was also no difference in the number of depression-related adverse events between the two study groups. In addition, there was no evidence that PrEP was less efficacious in depressed participants.