SCIENTIST NOW TRYING TO CONTROL LATENT HIV BY VORINOSTAT
PROF.DRRAM ,HIV/AIDS,SEX Diseases, Hepatitis .& Deaddiction Expert
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The Effect of Vorinostat on HIV RNA Expression in the Resting CD4+ T Cells of HIV+ Pts on Stable ART before and after a single exposure to Vorinostat (VOR), after exposure to short intervals of VOR, and after repeated short interval exposure to VOR dosed over several weeks.
The frequency of resting CD4+ T cell- associated HIV RNA (RCVL) will be increased following single and repeated exposure to VOR when given at appropriate intervals, and
That repeated exposure to VOR will reduce the frequency of HIV infection within resting CD4+ T cells (RCI)
SUCH FINDING STATES THAT CD4 COUNT BEING STABLE AND SHOWING RISE BUT STILL VIRAL LOAD BEING ZERO OR LESS BUT AFTER SUCH DRUG ADMINISTRATION HIDDEN HIV VIRUS WILL COME OUT FROM HIDDEN SITES OF HIV IN BODY INTO BLOOD AND WILL BE TAKEN BY ART MEDICINES WHICH WILL KILL THEM SO PERSONS WILL REMAIN HIV FREE ONCE VIRAL LOAD IS ESTABLISHED AS ZERO PROVIDED WE USE SUCH DRUG WITH ART AFTER VIRAL LOAD IS ACHIEVED ZERO BY ART AND SUNSEQUENTLY IN BETWWN MORE CHALLENG IS MET BY INFUSING SUCH DRUG IN BETWEEN SO THAT WE GET A STATE WHWN NO HIDDEN HIV REMAIN AND THUS WE ACHIEVE COMPLETE ERADICATION OF HIV FROM BODY THAN SIMPLE FUNCTIONAL CURE IF TREATED ALONE WITH CURRENT ART OR ARV OR HAART MEDICINES.