Human antibodies against specific diseases produced in lab to treat diseases

Prof Dr,DRAM,HIV /AIDS,HEPATITIS ,SEX DISEASES & WEAKNESS expert,New Delhi,India, +917838059592

Human antibodies against specific diseases produced in lab to treat diseases Till today we vaccinate one person with toxoid preparation or dead or live bacteria or Viral antigen to produce antibodies so that these preformed antibodies will not allow us to be infected by that causative agent of the disease and bu these smallpox,measles and polio has been almost eradicated from the world . In some diseases as in rabies,diphtheria,tetanus,gas gangrene we also use passive immunisation as animal produced antibodies or human variety antibodies by Recombinant DNA Technology in bacteria but a team of researchers led by Facundo Batista of Francis Crick Institute in London and Ragon Institute of MGH, MIT, and Harvard have been able to produce specific human antibodies against many diseases in the laboratory.Scientists have developed a method to artificially produce specific human antibodies which can be used to treat a single specific disease or wide range of diseases and facilitate the development of new vaccines.

"Our method offers the potential to accelerate the development of new vaccines by allowing the efficient evaluation of candidate target antigens," he added.The team successfully demonstrated their approach using various bacterial and viral antigens including the tetanus toxoid and proteins from several strains of 'influenza A'. In each case, they were able to produce specific, high-affinity antibodies in just a few days. Some of the anti-influenza antibodies generated by the technique recognised multiple strains of the virus and were able to neutralise its ability to infect cells.The procedure does not depend on the donors having been previously exposed to any of these antigens through vaccination or infection. The researchers were able to generate anti-HIV antibodies from 'B-cells' isolated from HIV-free patients.The technique, described in a paper published on Monday in 'The Journal of Experimental Medicine', could speed the production of antibodies by body's 'B-cells' that fight off infections by bacteria, viruses, and other invasive pathogens