KETAMINE IS AVERY POTENT ANTIDEPRESSANT WORKING EVEN IN 2 HRS 

PROF .DRRAM,HIV /AIDS,HEPATITIS ,SEX DISEASES & WEAKNESS expert,New Delhi,India, profdrram@gmail.com,+917838059592,+919832025033,ON WHATSAPP

Most anti depressant medicines takes usually2-3 weeks for bringing good result in depressed patients and some good medicines even donot bring any good effect while Ketamine an anaesthetic agent brings good result in antidepressant in as early as within two hours.Ketamine, an anesthetic, is one of several glutamatergic drugs affecting neurotransmitters in the central nervous system. 

        In patients with treatment-resistant major depressive disorder, ketamine produced initial reductions in depressive symptoms within two hours, with peak effects at 24 hours.Several studies have reported "rapid, robust, and relatively sustained antidepressant response" to ketamine, injected intravenously at low, subanesthetic doses, the researchers said.

           Ketamine and related drugs may represent a "paradigm shift" in the treatment of major depressive disorder and bipolar depression -- especially in patients who do not respond to other treatments, according to Carlos A. Zarate, from the National Institute of Mental Health, National Institutes of Health, in Maryland, US.The two studies on ketamine and other glutamatergic drugs for depression were published in the journal Harvard Review of Psychiatry. 

       Ketamine may also rapidly reduce suicidal thoughts. It has also produced rapid antidepressant effects in patients with treatment-resistant bipolar depression.However, since the drug is FDA-approved only as an anesthetic, use of ketamine in depressive disorders is "off-label", unregulated, and not standardized."Efforts are underway to bring ketamine to market, standardize its use, and determine its real-world effectiveness," Zarate said. 

        Independent of how ketamine works or its ultimate role in clinical treatment, antidepressant response to glutamatergic drugs points to an exciting conclusion: "that rapid antidepressant effects are indeed achievable in humans".