Scientists Behind Game-Changing Cancer Immunotherapies Win 2018 Nobel Medicine PrizeProf.Dr.Dram,profdrram@gmail.com,Gastro Intestinal,Liver Hiv,Hepatitis and sex diseases expert 7838059592,9434143550

 

 American James Allison and Japanese Tasuku Honjo won the 2018 Nobel Prize for Physiology or Medicine on Monday for game-changing discoveries about how to harness and manipulate the immune system to fight cancer.The scientists' work in the 1990s has since swiftly led to new and dramatically improved therapies for cancers such as melanoma and lung cancer, which had previously been extremely difficult to treat.

         Allison and Honjo showed releasing the brakes on the immune system can unleash its power to attack cancer. The resulting treatments, known as immune checkpoint blockade, have "fundamentally changed the outcome" for some advanced cancer patients," the Nobel institute said.

          Medicine is the first of the Nobel Prizes awarded each year. The prizes for achievements in science, literature and peace were created in accordance with the will of dynamite inventor and businessman Alfred Nobel and have been awarded since 1901.

              Allison's and Honjo's work focussed on proteins that act as brakes on the immune system - preventing the body's main immune cells, known as T-cells, from attacking tumours effectively.Allison, a professor at the University of Texas MD Anderson Cancer Center, worked on a protein known as CTLA-4 and realised that if this could be blocked, a brake would be released."It immediately occurred to me, and some of the people in my lab, that maybe we can use this to unleash the immune system to attack cancer cells," Allison told a news conference after getting the prize.

             Honjo, a professor at Kyoto University since 1984, separately discovered a second protein called PD-1 and found that it too acted as an immune system brake, but with a different mechanism.The discoveries led to the creation of a multibillion-dollar market for new cancer medicines.

          Bristol-Myers Squibb's CTLA-4 therapy Yervoy was the first such drug to win approval, in 2011. However, it is medicines targeting PD-1 blockade that have proved a bigger commercial hit, led by Merck & Co's Keytruda in 2014.These and rival drugs from Roche, AstraZeneca, Pfizer and Sanofi now offer new options for patients with melanoma, lung and bladder cancers.Sales of such medicines, which are given as infusions, are expected to reach some $15 billion this year, according to Thomson Reuters consensus forecasts. Some analysts see eventual revenues of $50 billion.

       Commenting on the award, Kevin Harrington, a professor at the Institute of Cancer Research in London, said the work had revolutionised cancer treatment."We’ve gone from being in a situation where patients were effectively untreatable to having a range of immunotherapy options that, when they work, work very well indeed," he said in a statement. "For some patients we see their tumours shrink or completely disappear and are effectively cured."