TREATMENT OF OBESITY BY ACUPUNCTURE

Cabýoglu and Ergene (2005) applied body and ear acupuncture for 20 days

to 22 women who had a body mass index (BMI) between 30 and 40 while a 1425 Kcal diet program was prepared for 21 women under the same circumstances.Besides, there was a control group including 12 women. In this study, associated with body weight, levels of the serum total cholesterol, triglyceride, HDL cholesterol and LDL cholesterol in obese women were examined. In acupuncture treatment, the Hungry and Shen Men ear points, and the Hegu (LI 4), Quchi (LI 11), Tianshu (St 25), Zusanli (St 36), Neiting (St 44) and Taichong (Liv 3) body points were used. There was a 4.8% weight reduction in obese women with electroacupuncture application, whereas obese women in diet restriction had a 2.5% weight reduction. There were significant decreases in total cholesterol and triglycerides levels in EA and diet groups compared with the control group. Furthermore, there was a decrease in LDL levels in the EA group compared with those in the control group.

Huang et al. (1996) applied auricular acupuncture and diet and aerobics exercise programs for 8 weeks to 8 men who had a body mass index (BMI) over 30 and body fat rate over 25% and to 37 women who had a BMI over 30 and body fat rate over 30%. In the auricular acupuncture application, the points Shen Men, Stomach, Sanjiao, and Hungry were chosen. Weekly application was made to a single ear each session, using one ear in one session and the other ear in the next session. The diet program was prepared by a dietician to meet the daily needs of the people participating in the study by calculating their anticipated daily activities, as well as other factors. The exercise program was arranged to be 3 to 5 times per week and to burn 300 to 500 kcal of energy in each session. As a result of this triple application, an average 4.4 kg body weight loss and a 5.6% reduction in body fat rate were observed.

Sun and Xu (1993) applied auricular and body acupuncture therapy to

110 obese patients. In this study, a small, spherical seed, a method employed in traditional Chinese acupuncture, was applied to the auricular acupuncture points, Mouth, Esophagus Stomach, Shen Men, Lung, and Endocrine in sessions three to five days apart. This application was made first on one ear and then on the other ear in the following session.

Additional application was

made to the body acupuncture points Tianshu (St 25), Zusanli (St 36), Sanyinjiao (Sp 6), Neiguan (P 6), and Fenglong (St 40). This application was performed once every 3 to 5 days, in 15 min sessions over 3 months. As a result of these applications, a 5.0 kg loss in body weight was observed.Shafshak (1995) performed a study with 30 obese females, dividing them into three groups each including 10 females. He applied electroacupuncture to the Stomach points on both ears of the subjects in the first group, to the points on both ears of the subjects in the third group. These applications continued once a day, five days a week, for three weeks. Also a diet of 1000 kcal/day was advised to patients. In the first group, 80% of the patients managed to apply the diet. The rate of diet application for the second group was 70%, whereas that of the third group was 20%. In all patients applying the diet, the observed body weight loss was 1 to 4 kg in the first group, 1.5 to 3.5 kg in the second group and 1 to 3 kg in the third group. According to the results of this study, it was observed that the auricular acupuncture points Stomach and Hungry were effective in weight loss when compared with placebo points.

Through electroacupuncture to obese people, increases in the serum triglyceride and LDL cholesterol levels and a decrease in the serum HDL cholesterol levels were reported by Lyznicki and his colleagues (2001). These two levels are thought to have particular ties to cardiovascular disease. Liu et al. (1992), using the ear and body acupuncture points of traditional Chinese acupuncture, applied acupuncture to 102 obese people and studied the changes in body weight and plasma levels of total cholesterol, triglycerides, HDL cholesterol, and LDL cholesterol. Ear acupuncture was applied once every 5 days and body acupuncture was performed once every 3 days in 20-min sessions over a 1 month period. In Liu’s study, a weight loss with a mean value of 3.3 kg was noted. Also, decreases in plasma levels of total cholesterol, triglyceride, and LDL cholesterol levels and an increase in the HDL cholesterol level were observed. Sun and Xu (1993) performed ear and body acupuncture to obese people and analyzed the changes in body weight and levels of total cholesterol, triglyceride, and HDL cholesterol. They applied acupuncture to the Mouth, Esophagus, Stomach, Shen Men, Endocrine, and Lung acupuncture points on one ear once every three or five days, and on the other ear in the next session by using small seeds that are used in some traditional Chinese acupuncture methods. They also applied acupuncture to the St 25, St 36, Sp 6, P 6, and St 40 body points once every three or five days using acupuncture needles. In their study, it was observed that decreases in plasma levels of total cholesterol and triglyceride corresponded with weight loss. Therefore, they concluded that EA therapy may be a useful approach to treatment of obesity and potentially decrease the risk factors associated with obesity.

Stimulation of the Hungry point creates an increase of the fullness feeling and a repression of the hunger feeling (Asomoto & Takeshige, 1992).

Stimulation of the Shen Men point regulates cerebral cortex function and has Hungry points on both ears of the subjects in the second group, and to placebo

a sedative effect (Wang & Kain, 2001). Stimulation of the Stomach point stimulates the auricular branch of the vagal nerve, which has been shown to increase tone in the smooth muscle of the stomach, thus suppressing appetite (Richards & Marley, 1998). Stimulation of the LI 4, LI 11, and St 25 body acupuncture points has a regulatory effect on intestinal motility (Maciocia, 1989), whereas stimulation of St 36 and St 44 increases excitability of the satiety center in the ventral medial nucleus of the hypothalamus (Zhao et al., 2000). In traditional Chinese medicine, the St 36 body acupuncture point has been used for the treatment of both diarrhea and constipation. This point has been reported to regulate gastrointestinal motility by increasing motility in people with hypoactive intestinal motility and conversely by decreasing motility in people with hyperactive intestinal motility (Li et al., 1992). Stimulation of this point also increases the amplitude and frequency of gastric peristalsis that shortens gastric emptying time and delays the contraction time in regular people (Li et al., 1992).

ACUPUNCTURE APPLICATION AND SUPPRESSING APPETITE

In the treatment of obesity, acupuncture applications, especially auricular acupuncture, are very effective for losing weight in obese people (Sun & Xu, 1993; Lei, 1988; Mulhisen & Rogers, 1999). Although diet application causes weight loss in obesity treatment, it has no effect on suppression of appetite (Richards & Marley, 1998). Many overweight people are aware that diets can help with weight loss but have difficulty in suppressing their appetite. However, it has been determined that acupuncture application is effective both in weight loss (Zhan, 1993; Sun & Xu, 1993) and in suppression of appetite (Shiraishi et al., 1995; Zhao et al., 2000).

Shiraishi et al. (1995) reported the changes in neural activity of the ventromedial (VMH) and lateral hypothalamus (LH) through auricular acupuncture application on normal and experimentally obese rats. One experimental group of obese rats was obtained by destroying the ventromedial hypothalamus and another through a high-calorie diet. Auricular acupuncture application was performed to the region that was innerved by the nervous vagus on a single ear. This region is called the cavum conchae on human beings. Although the neural activity of the LH is diminished in normal rats by auricular acupuncture application, the neural activity of the VMH is increased.

Likewise, neural activity of the LH was reduced in both of the two

experimental groups of obese rats, and neural activity of the VMH was increased

in the group of high-calorie diet, obese rats. As a result, it was determined that auricular acupuncture application is effective in the formation

and protection of the satiety sense in both normal and obese rats.  Zhao et al. (2000) in their study on rats, applied electroacupuncture on one side of the body on 1 day and on the other side the following day, for 12 days in 5-min daily sessions. For this test, they chose the Zusanli (St 36) and Neiting (St 44) points. It was observed that electroacupuncture application on rats increased excitability of the satiety center in the ventromedial nucleus of the hypothalamus.

Wenhe and Yucan (1981) observed that the level of serotonin (5-HT) in the central nervous system increased with acupuncture application (Figure 1).

Serotonin has been implicated in the control of eating behavior and body

weight. Stimulants of this monoamine reduce food intake and body weight,

increase energy expenditure (Curzon, 1990; Simansky, 1996), and enhance

intestinal motility (Guyton & Hall, 2001). This effect of 5-HT that reduces

food intake can be observed on 5-HT receptors of the satiety center in the

ventromedial nuclei of the hypothalamus (Sarah et al., 1998). Besides that, it

was noted that serotonin gave happiness, helped a person to feel good, controlled

the sexual motivation, and had a role in obtaining the psychomotor

balance (Guyton & Hall, 2001). Acupuncture stimulates the auricular branch

of the vagal nerve and raises serotonin levels. Both of these activities have

been shown to increase tone in the smooth muscle of the stomach, thus

suppressing appetite (Richards & Marley, 1998). It is thought that an increase

in the level of serotonin in the central nervous system with acupuncture

application can provide weight loss, as it has a role in both reducing

food intake and arranging the psychomotor balance ACUPUNCTURE, BETA ENDORPHIN,

AND LIPOLITIC ACTIVITY

In many studies it has been observed that electroacupuncture application caused an increase in the levels of beta endorphin both in serum and in the central nervous system (Jin et al., 1996; Takeshige et al., 1992, 1993; Fu, 2000; Petti et al., 1998) (Figure 1). It has been determined that electroacupuncture application with different current frequencies causes the secretion of different endojen opioids. It also has been observed that low current frequency (2 Hz) electroacupuncture application increases the concentration of endomorphins, enkephalins, and beta endorphin but high current frequency (100 Hz) electroacupuncture application increased the concentration of dynorphin in the central nervous system (Han et al., 1999) (Figure 1).

The studies that showed the lipolitic activity of pro-opiomelanocortin

products were performed as in vivo and in vitro studies on animals (Schwandt,

1985; Richter et al., 1983; Richter & Schwandt, 1985). Richter et al. (1983)

investigated the lipolitic activity of beta endorphin in the isolated fat cells of

rabbits in vivo. It was determined that as a result of the effect of beta endorphin on fat cells, the levels of free fatty acid and glycerol increased in the rabbit

plasma. This effect was blocked by naloxone. Vettor et al. (1993) studied the lipolitic activity of beta endorphin in isolated human fat tissue. In their study, it was observed that whereas BE application caused the increase of glycerol secretion from isolated fat cells, naloxone inhibited this effect.  According to the results obtained from these studies, it is thought that electroacupuncture, which increases the plasma beta endorphin levels, can contribute to the weight loss by increasing the lipolithic activity (Figure 3).

CONCLUSION

It has been observed that acupuncture application depresses the appetite by

activating the satiety center in the hypothalamus and increasing sympathetic

activity through an increase in the concentration of serotonin in the central

nervous system of obese people. Acupuncture stimulates the auricular branch

of the vagal nerve, which has been shown to increase tone in the smooth

muscle of the stomach, thus suppressing appetite. It also controls stress and

depression via endorphin and dopamine production. In addition to these

effects it is thought that the increases of plasma levels of beta endorphin

naturally occurring after acupuncture application can contribute to body weight loss in obese people. This is accomplished by mobilizing the body energy

depots by lipolithic effect. Through these mechanisms, acupuncture application can be seen as an effective therapy in the treatment of obesity.

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