HIV /AIDS: HIV VIRUS IN HUMAN BEING MUTATE OR CHANGE SO BADLY IN SIDE BODY THAT DRUGS ONCE BEING STARTED IF NOT TAKEN REGULARLY THEN DRUG RESISTANCE OCCURS BECAUSE VIRUS CONFIGURATION OR PROTEIN OR ITS VARIETY CHANGES AND DRUG BECOMES LESS EFFECTIVE .
PROF.DRRAM ,HIV/AIDS,SEX DIS.,SEX WEAK.& ABORTION SPECIALIST
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SUCH MUTATION OR CHANGE IN VIRUS IS MORE AS IT IS A SIMPLE VIUS HAVING A SMALL PROTEIN AS NULCEAR MATERIAL WHICH CHANGES SO THAT DRUG CANNOT KILL IT MORE AND THAT IS WHY EVEN VACCINE PODUCTION AGAINST VIRUS IS NOT POSSIBLE.
AS VACCINE WORKS FOR ONE VIRUS AND AS VIRUS CHANGES OR MUTATES SO NEW STAIN PRODUCED SO THIS VACCINE BECOMES INEFFECTIVE SO VIRUS REMAIN GROWS.SAME FOR DRUG ,THEREFORE WE GIVE TWO OR THREE DRUG COMBINATIONS SO THAT VIRUS CANNOT MUTATE EASILY AND ONE AND ANOTHER DRUG WILL KILL IT UNLIKE IF WE USE ONE DRUG TO WHICH IT WILL MUTATE EASILY,SAME WAY NEW DRUGS ACTING DIFFERENTLY AS NULEOSIDE OR NUCLEOTIDE REVERSE TRANSVERSE INHIBITORS as Lamivudine ,NON NUCLEOSIDE REVERSE TRANSCRIPTOR INHIBITORS Efavirenz ,PROTEASE INHIBITORS as ritonavirFUSION INHIBITORS,RECEPTOR BLOCKERS as Raltegravir used
HIV VIRUS OCCUPIES SOME CD4 CELLS OF HOST WHICH HIDE WELL INSIDE BODY AND REMAIN SO FOR YEARS HARD TO KILL THESE CELLS WHICH ARE HIDDEN INSIDE BODY SO CANNOT BE ERADICATED COMPLETELY WHENEVER DRUG IS ABSENT OR PATIENT IMMUNITY COMPROMISES THE THIS VIRUS AGAIN GROWS AND PRODUCE SYMPTOMS,SO ONCE TREATMENT STARTS THEN IT IS FOR LIFE WITH ADVICE OF GOOD LIFE FULL OF EXCERCISE AND NUTRITION SO THAT IMMUNITY REMAINS HIGH.
SAME WAY IF PERSON AFFECTED CONTINUE TO SEX WITHOUT CONDOM WITH MULTIPLE PARTNERS WHETHER HOMO GAY OR LESBIN OR HETERO OR MSM THEN NEW STAIN ENTERS MIX WITH ANOTHER OF PT AND PRODUCE A NEW STRAIN HRD TO BE CONTROLLED BY ARV MEDICINES USED AND PATIENT BECOMES RESISTANT TO ALL DRUGS SO PATIENT SHOULD LIVE A LIFE LOYAL TO PARTNER AND USE CONDOM DURING SEX WITH WIFE EXCEPT FOR TAKING CHILD ONCE OR TWICE UNDER MEDICAL GUIDANCE COMPLETELY WITH VERY VIRAL LOAD AND FULL ARV COVERAGE OF MEDICINES.

HIV : AIDS : FAMILY PLANNING IS A MUST FOR HIV COUPLE -DANGER OF SPREADING TO INNOCENT CHILDREN IS A KNOWN CRIME
PROF.DRRAM ,HIV/AIDS,SEX DIS.,SEX WEAK.& ABORTION SPECIALIST
profdrram@gmail.com,+917838059592,+919832025033,DELHI –NCR,IND
HIV/ AIDS,CANCER LATEST MEDICINES AVAILABLE AT CHEAP RATE.
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WE should try our best to educate every hiv/aids persons if living in family that they should take all precutions themselves that this doisease doesnot reach their life parner(using condom during sex,sex is not a bar with negative partner but condom is a must even when viral load is minimum except 1-2 times sex allowed without condom for pregnancy under strict medical guide ) use all method of avoiding contamination of their blood,semen,body fluid like saliva,spits urine ,stool leakage of fluid from brain,cut injury from any where,sputum but not tears and sweat to mix with negative meber at home particularly children and family members or person at office or working place and health staff giving them service,never hide your disease,there is no shame no stigma,it is a disease it happened to you and can happen to me or any body .
Second if 1-2 child born then they should undergo vasectomy or tubectomy permannantly to avoid further pregnancy.if not interested in permannant one then woman can use pills or IUCD insersation .simple sex during non ovulation period or sperm ejaculation out side or spermicide or vaginal spermicide jelly is not that protective one.
Sex with condom is amust as if two hiv positive persons meet their genotype of virus may be different and a new virus genotype in one person and vice versa.so avoid sex without condom even with life partner what to talk of sex with stanger where condom is a must.
never transfuse blood to any person,never share needle,never donate blood or any other organ.

AIDS / HIV & HEPATITIS C INFECTION: RECENT TREATMENT MODULE OF TREATING HIV AND HEPATITIS TOGETHER WITH SOFOSBUVIR

PROF.DRRAM ,HIV/AIDS,SEX DIS.,SEX WEAK.& ABORTION SPECIALIST
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HIV/ AIDS,CANCER LATEST MEDICINES AVAILABLE AT CHEAP RATE.
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Hepatitic C is a silent infection like HIv and is common with many patients of hHiv particualrly those are IV DRUG USER OR BLOOD CONTAMINATED.WITH HEPATITIS C HIV MUST BE TREATED FIRST AS START ANTI HIV TREATMENT OR ARV MEDICINES FIRST KEEP VIRAL LOAD OF HIV LOW AND CD4 COUNT MORE FOR BETTER RESULTFOR HCV CURE.
Hepatitis c produce cirrhosis of liver and liver cancer if not treated,we decide to treat it when we see that Liver function of patient deteriorates,Features of cirrhosis like Pedal Oedema,Black spots,Dilated abdominal Veins,Piles or oesophageal varices with Ascites or fluid in abdome with splenomegaly starts and cirrhosis confirmed by either Biopsy or Fibroscan or Usg or we see features of cancer then we resect this liver and transplant new one and with it we treat hepatitis c too.
so,if liver enzymes alters or fetures of cirrhosis starts of if HCV viral load IU/ML OR COPIES/ML(1IU/ML=7COPIES/ML) seen in good concentration and patient opt for therapy as if treatment taken completed than unlike HIV,HCV is curable after 12-24 wks now with sobosfuvir and previously 48 wks without sofosbuvir SVR (SUSTAINED VIRAL RESPONSE) OR VIRAL LOAD ZERO OF HCV IS POSSIBLE
we see that what type of HCV it is as Genotype 1 or 1A or 1B or type 2,Type 3 or type 4 .Genotype HCV 1A and type 4 are hard to treat they need peglyated Interferon with Ribvarin for 24-48 wks with Bocprevir and telaprevir either if alone or with HIV but with Sofosbuvir now it is found that interferon-free regimen of sofosbuvir plus ribavirin for 24 weeks led to sustained response in three-quarters of previously untreated people with genotype 1 hepatitis C and HIV co-infection in the PHOTON-1 study,and 12 wks therapy for type 2 but for type 3 also a course of 24 wks needed like type 1A not shorter 12 wks as for type 2 as we think type 2 and type 3 are easy responders.according to a report at the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) this week in Boston.

People with HIV/HCV co-infection experience more rapid liver disease progression and do not respond as well to interferon-based therapy as people with hepatitis C alone. Direct-acting antivirals like sofosfuvir or SOVALIDI or PREVIOUS KNOWN GS-7977 that target different steps of the HCV lifecycle offer the prospect of shorter treatment, fewer side-effects and higher cure rates for both HCV mono-infected and HIV/HCV co-infected patients.In less advanced case or type 2 or type 3 simprenavir can also be tried.Previous to this costly Sofosbuvir (ruprees 50000 dollars for one month )but pegylated Interferon is very toxic and cannot be easily tolerated by every pateient previously we were using INTERFERON ALPHA 2a OR ALPHA 2b which dose was twice a week but now pegylated once a week injection,Ribarin in dose 0f 1000-1200 mg as per body weight and Sofosbuvir 400 mg once a day only.