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Jan 17
Average cough lasts for 18 days
If you got a pesky cough and it hasn`t gone away in a week, you shouldn`t fret as a new study has found that the average cough lasts 18 days.

The problem is that people may believe that acute coughs - otherwise known as acute bronchitis-last about 10 days shorter than that, leading researchers to believe that many of them unnecessarily ask their doctor for antibiotics.

The Centers for Disease Control and Prevention estimates that acute cough illness makes up two to three percent of doctor visits, and more than half of them leave with an antibiotic prescription.

"There is a mismatch in what people believe and reality," CBS News quoted Dr. Mark Ebell, associate professor of epidemiology in the UGA College of Public Health, as saying.

"If someone gets acute bronchitis and isn`t better after four to five days, they may think they need to see a doctor and get an antibiotic. And when the first one doesn`t work, they come back four or five days later for another," he said.

The study looked at 19 observational studies that had between 23 and 1,230 patients. The studies took place in the US, Europe, Russia and Kenya.

From the data, it was determined that acute cough illness lasts 17.8 days on average.

The study is published in the journal Annals of Family Medicine.

Jan 17
Migraine with aura may up heart risk in women
Migraine headaches accompanied by flashes of light or other visual disturbances, called aura, could be an indicator of increased heart attack risk among women, a new study has found.

The study involved 27,860 women, aged 45 and above, out of which 1,400 suffered from migraine with aura. None of them had cardiovascular disease at the beginning of the study.

During the 15-year study period, there were 1,030 cases of heart attack, stroke or death from a cardiovascular event.

"After high blood pressure, migraine with aura was the second strongest single contributor to risk of heart attacks and strokes- ahead of Type 2 diabetes, smoking and obesity," said study researcher Dr. Tobias Kurth, of the French National Institute of Health and Medical Research in Bordeaux.

The findings do not mean that all women who have migraines with auras will have a heart attack or stroke, but, there is a possibility that common factors may be involved in both migraines and cardiovascular events, Kurth said

Migraines with aura occur when blood vessels in the brain constrict, thereby reducing blow flood to a certain area.

The study, which has not yet been published, will be presented in March at the American Academy of Neurology`s annual meeting in San Diego.

Jan 16
Eat strawberries and blueberries to stave off heart attack
Eating strawberries and blueberries all year round can cut the risk of heart attack by up to a third in women, a new study has claimed.

Experts believe the benefits come from the high content of flavonoids in berry fruits, which appear to combat blocked arteries, the `Daily Mail` reported.

Flavonoids are antioxidant compounds found in plants, as well as tea and red wine, which can protect against a wide range of diseases, including heart disease, hypertension, some cancers and dementia.

The findings are from an ongoing study of nurses which involves only women, but may also apply to men, researchers said.

The study involved 93,600 participants in the Nurses` Health Study II, a major US investigation of women`s health.

Women aged 25 to 42 completed questionnaires about their diet while their health was monitored over 18 years.

During the study, 405 heart attacks were recorded.

Women who ate the most strawberries and blueberries - at least three times a week - were at 32 per cent lower risk than those consuming the berries once a month or less.

Even participants with diets rich in other fruits and vegetables were more likely to experience heart attacks if they avoided strawberries and blueberries.

"Blueberries and strawberries can easily be incorporated into what women eat every week. This simple dietary change could have a significant impact on prevention efforts," Dr Eric Rimm, one of the senior study authors from the Harvard School of Public Health in Boston, said.

Scientists believe the protective effect could be linked to anthocyanins, a type of flavonoid that may help open up arteries and counter the build-up of fatty deposits on blood vessel walls.

"We have shown that even at an early age, eating more of these fruits may reduce risk of a heart attack in later life," Nutritionist Dr Aedin Cassidy, from the University of East Anglia, who took part in the research, said.

"This study found an association between a diet rich in red and purple fruits, such as blueberries, blackberries and strawberries, and a reduction in heart attack risk for young and middle aged women," Victoria Taylor, Senior Dietitian at the British Heart Foundation, said.

"However, more research is needed to understand why this link between berries and better heart health exists. We would need to know more before we make specific recommendations about individual fruit and vegetables in relation to heart disease," Taylor said.

The study was published in the American Heart Association journal Circulation.

Jan 16
Australian scientists discover 'potential cure for AIDS'
Researchers at Queensland Institute of Medical Research here have claimed of making a breakthrough that could lead to a potential cure for AIDS.

According to a researcher David Harrich scientists have discovered how to modify a protein in HIV so that, instead of replicating, it protects against the infection.

Harrich said, "I consider that this is fighting fire with fire. What we`ve actually done is taken a normal virus protein that the virus needs to grow, and we`ve changed this protein, so that instead of assisting the virus, it actually impedes virus replication and does it quite strongly."

Harrich added that modified protein cannot cure HIV but it has protected human cells from AIDS in the laboratory.

"This therapy is potentially a cure for AIDS. So it`s not a cure for HIV infection, but it potentially could end the disease", he said.

Over 30,000 people have been diagnosed with HIV in Australia. If clinical trials are successful, one treatment could be effective enough to replace the multiple therapies they currently need.

"Drug therapy targets individual enzymes or proteins and they have one drug, one protein," Associate Professor Harrich said.

He added that they have to take two or three drugs, so this would be a single agent that essentially has the same effect.

"So in that respect, this is a world-first agent that`s able to stop HIV with a single agent at multiple steps of the virus lifecycle."

He said that the new treatment has the potential to make big improvements in the quality of life for those carrying HIV. I think what people are looking for is basically a means to go on and live happy and productive lives with as little intrusion as possible.

"You either have to eliminate the virus infection or alternatively you have to eliminate the disease process and that`s what this could do, potentially for a very long time." Harrich said animal trials are due to start this year and early indications are positive", Harrich said.

He said, "This particular study is going to have some hurdles to jump through, but so far every test that we have put this protein through has passed with flying colours.

Jan 15
Vitamin D may not ease knee pain: Study
Vitamin D supplements do not appear to ease knee pain in people with kneeosteoarthritis, a new study has claimed.

Researchers found that people with kneeosteoarthritis who took vitamin D supplements every day for two years did not experience improvements in knee pain compared to people who took a placebo.

Knee osteoarthritis is a form of arthritis in which cartilage in the knee joint breaks down, resulting in bone rubbing on bone.

It typically affects men and women over 50 years of age, and occurs most frequently in obese individuals. Symptoms include pain or stiffness in or around the knee, swelling and limited range of motion, website MyHealthNewsDaily reported.

Currently, there are no proven treatments to slow the course of the disease, the researchers said.

Vitamin D plays a role in bone health, and previous studies had suggested that knee osteoarthritis progresses more slowly in people with high vitamin D levels.

During the new study, 146 people ages 45 and older who had knee osteoarthritis were randomly assigned to receive either 2000 International Units (IUs) of vitamin D per day or a placebo.

Dosages of vitamin D were periodically increased to more than 2000 IUs so that the amount of the vitamin in the blood reached a level that has been associated with benefits.

The recommended daily dose is 600 IUs for people younger than 70, and 800 IUs for people older than that.

Every two to four months, subjects rated the pain in their knee on a scale of zero to 20, with 20 representing extreme pain. Researchers also took images of each person`s knees using magnetic resonance imaging (MRI).

After two years, the two groups showed no difference in knee pain: on average, pain scores in both groups decreased by about two points.
In addition, the image results showed that people who took Vitamin D lost just as much cartilage in the knee joint as those who took a placebo.

The study researchers could not say whether or not people who take vitamin D before they develop knee osteoarthritis might experience a benefit.

But previous studies have found no link between a person`s vitamin D levels and the risk of developing knee osteoarthritis, said study researcher Dr Timothy McAlindon, a rheumatologist at Tufts University Medical Center in Boston.
Pain medication, as well as physical therapy, may help reduce pain from osteoarthritis, according to the Mayo Clinic.

The study was published in the Journal of the American Medical Association.

Jan 15
Childhood obesity causes immediate health problems
While the long-term health problems brought on by childhood obesity, little has been told of the condition`s immediate consequences on the youngsters.

Now, a new UCLA study has found that obese youngsters are at far greater risk than had been supposed.

Compared to kids who are not overweight, obese children are at nearly twice the risk of having three or more reported medical, mental or developmental conditions, the UCLA researchers found. Overweight children had a 1.3 times higher risk.

"This study paints a comprehensive picture of childhood obesity, and we were surprised to see just how many conditions were associated with childhood obesity," said lead author Dr. Neal Halfon, a professor of pediatrics, public health and public policy at UCLA, where he directs the Center for Healthier Children, Families and Communities.

"The findings should serve as a wake-up call to physicians, parents and teachers, who should be better informed of the risk for other health conditions associated with childhood obesity so that they can target interventions that can result in better health outcomes."

The new UCLA research, a large population-based study of children in the United States, provides the first comprehensive national profile of associations between weight status and a broad set of associated health conditions, or co-morbidities, that kids suffer from during childhood.

Overall, the researchers found, obese children were more likely than those who were classified as not overweight to have reported poorer health; more disability; a greater tendency toward emotional and behavioral problems; higher rates of grade repetition, missed school days and other school problems; ADHD; conduct disorder; depression; learning disabilities; developmental delays; bone, joint and muscle problems; asthma; allergies; headaches; and ear infections.

For the study, the researchers used the 2007 National Survey of Children`s Health, analyzing data on nearly 43,300 children between the ages 10 and 17. They assessed associations between weight status and 21 indicators of general health, psychosocial functioning and specific health disorders, adjusting for sociodemographic factors.

Of the children in the study, 15 percent were considered overweight (a body mass index between the 85th and 95th percentiles), and 16 percent were obese (a BMI in the 95th percentile or higher).

The study will be published in the January-February print issue of the journal Academic Pediatrics.

Jan 14
Pill-sized scanner images gullet
Doctors have made a pill-sized device that can take detailed microscopic images of inside the gullet.

It is hoped the US technology could become an easier way of screening people for a condition called Barrett's oesophagus, which can lead to cancer.

Unlike current imaging techniques, the device can be used while the patient is conscious and takes only a few minutes.

The device has been tested in a small number of patients so far, Nature Medicine reports.

Although researchers at Wellman Center for Photomedicine at Massachusetts General Hospital in Boston say the device has potentially wide application, it could be particularly useful for Barrett's oesophagus where many people do not realise they have it, but there is no easy way to screen for it.

In those with the condition, the cells in the lower gullet become abnormal due to chronic acid reflux, which puts them at a higher risk of developing cancer of the oesophagus.

Doctors can screen those at risk using an endoscope - a flexible tube containing a tiny video camera - but this is unpleasant and usually has to be done under sedation.
Tiny capsule

The new device is contained in a capsule about the size of a multivitamin pill connected by a thin wire.

Within the capsule is a rapidly rotating laser tip which emits infrared light that is then reflected back from the lining of the oesophagus.

The image doctors see on the screen is a 3D landscape showing far more microscopic detail than can be seen with endoscopy.

When the patient swallows the capsule it is carried down the oesophagus in the same way any piece of food would be then once it reaches the stomach it can be pulled back out using the wire.

Images are taken the whole time the device is moving up and down the gullet and the whole process takes a matter of minutes.

Testing the equipment in six patients known to have Barrett's oesophagus and seven healthy volunteers, the researchers said the images clearly showed the cellular changes that occur in those with the condition.
'Best pictures'

Prof Gary Tearney, one of the research collaborators, said the technology is cheaper than endoscopy and avoids the need for sedation, specialised equipment or special training.

And the microscopic detail shown in the images means a biopsy can be avoided.

"The images produced have been some of the best we have seen of the oesophagus," says Prof Tearne, a professor of pathology at Harvard Medical School.

"We originally were concerned that we might miss a lot of data because of the small size of the capsule, but we were surprised to find that, once the pill has been swallowed, it is firmly 'grasped' by the oesophagus, allowing complete microscopic imaging of the entire wall."

Prof Tearney added that the device could help doctors work out who is at risk and detect cancers at potentially more treatable stage.

Prof Rebecca Fitzgerald, a specialist on Barrett's oesophagus at the Cambridge Cancer Centre, said: "It is elegant technology. The downside is that you will have to endoscope anyone with suspected Barrett's as you will have no way of sampling and detecting dysplasia [abnormalities] with this technology."

Jan 14
New York State declares influenza emergency
The US is in the midst of the worst flu outbreak in years

The governor of New York State, Andrew Cuomo, has declared a public health emergency because of the severity of this year's influenza season.

The order makes vaccinations more accessible and allows pharmacists to administer vaccines to children.

Almost 20,000 cases of flu have been reported in New York state so far this season - more than four times the number of cases last winter.

The flu outbreak has reached epidemic proportions across the US.

Last week 7.3% of US deaths were caused by pneumonia and the flu, just above epidemic threshold, said the US Centers for Disease Control and Prevention.

Flu activity was widespread in 47 states, up from 41 the week before.

Experts recommend flu vaccines, which have been found to be 62% effective.

The 2012-13 flu season is said to have started earlier than usual, with many cases of the H3N2 strain, which can be severe.

Some analysts say the latest numbers suggest the worst of the season may have passed.

The only states without widespread flu were California, Hawaii and Mississippi.

Flu symptoms can include fever, cough, runny nose, body ache and fatigue.

Severe cases could see vomiting and diarrhoea or develop into pneumonia. Many cases are much milder.

Jan 12
Drinking 4 cups of tea per day can cut stroke risk
Drinking four cups of tea a day can reduce the risk of a stroke by more than a fifth, a new study claims.

Scientists who studied how consumption of black tea - the kind mostly drunk in the UK - related to strokes found downing at least four cups every day lowered the chances of a brain blood clot by 21 percent, the Daily Mail reported.
But drinking any less than that did not seem to have a beneficial effect.

The findings, by scientists at the Karolinska Institute in Stockholm, Sweden, come from a population study involving nearly 75,000 men and women.

Strokes kill around 200 people every day in the UK. Many more are left disabled and living in fear that a second or even third attack could kill them.

Around 85 percent of victims are affected by ischaemic strokes, where a clot travels to the brain and shuts off its blood supply.

The rest are called haemorrhagic strokes, where a blood vessel bursts in the brain, causing potentially fatal bleeding.

Although numerous studies have highlighted the protective effects of green tea on the brain, the evidence on black tea has been less conclusive.

The Swedish team studied 74,961 Swedish adults who were in good health when they signed up to a long-term health study in 1997.

Over the next ten years, just over 4,000 of the volunteers suffered a stroke, mostly ischaemic.

As part of the study, researchers monitored tea drinking habits.

Once they allowed for other factors that might determine stroke risk - such as whether volunteers smoked or had high blood pressure - they found that four cups or more a day had a significant effect.

British consumers get through an estimated 165 million cups every day of mostly black tea.

It is packed with components called flavonoids that are thought to be good for the heart and brain.

Jan 12
Tiny molecular machine apes cellular production line
Manchester scientists have developed a tiny molecular machine that mirrors the function of the ribosome, which builds the proteins in our body's cells.

Just a few millionths of a millimetre in size, the minute machine resembles a ring threaded on a rod.

As this ring moves along the rod, it picks chemical units and assembles them into chains, just as ribosomes join up the building blocks of proteins.

The ultimate goal is to synthesize new drug molecules or new types of plastic.

"Just as robots are used to assemble cars in factories in the big world, one day we hope we will be able to use artificial machines like these in molecular factories to construct new things with great efficiency," said Prof David Leigh FRS from the school of chemistry at Manchester University, UK.

"Ribosomes make proteins, which are just one type of polymer used by nature. In fact, all of biology is based on just four sorts of so-called information polymers - proteins, DNA, RNA and also carbohydrates.

"But with our artificial machines, we're not limited by the same building blocks of nature. So, we should be able to make new materials with other types of building blocks - new types of plastics, new types of catalysts, pharmaceuticals and so on," he told the BBC World Service Science In Action programme.

A scholarly paper in this week's Science Magazine carries details of the research.

The ribosome is one of nature's true marvels. This giant molecule concerns itself with the business of translating and acting on our genetic code.

That code, held in the cell's DNA, is delivered to the ribosome by the "messenger" molecule RNA.

The ribosome reads the code and assembles long polymer chains out of amino acids. These chains then fold to form proteins, and it is the proteins that go on to build and maintain our bodies.

An artificial ribosome, like the one developed in Manchester, functions in a similar way.

The machine's chemical structure is based on a rotaxane, a molecular ring threaded on to a rod. A "reactive arm" is attached to the ring and works its way down the rod, removing and stacking the amino acid units bound to the rod.

A key point is that the sequence for a new polymer chain comes from the scientists. It is controlled by the chemical groups placed along the rod structure.

"The degree of control we have in this is exquisite," said Prof Leigh.

At the moment, the team is only producing small molecules, or peptides, that comprise chains of just a few units in length. This will have to be scaled up to the many tens of units achieved by ribosomes.

But just as insulin for diabetics today is produced in vast vats by engineered microbes, so in the future the Manchester team envisages containers carrying millions upon millions of their artificial machines all churning out the programmed molecules.

"Even though each machine is producing one molecule at a time, if you have a million, million, million of them, all acting to produce the same molecule, then you can produce qualities of the molecule that you can see in a reasonable period of time," said Prof Leigh.

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