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Aug 16
Brain activity predicts childhood risk for anxiety, says research
Childhood anxiety is a condition supposedly noted in children who remain socially unconnected. Apparently researchers from the UW-Madison pinpoint elevated brain activity in the amygdala and anterior hippocampus to help decide new strategies for early detection and treatment of at-risk children. Scientists assume children having higher activity in these brain regions to develop anxiety and depression.

In a prior investigation, it was concluded that anxious young monkeys are similar to children who are temperamentally anxious. In the course of the present research, experts assayed the extent of genetic and environmental factors to promote activity in the anxiety-related brain regions, making children accessible. Claimed to be the largest imaging research of non-human primates, scientists scanned the brains of 238 young rhesus monkeys. It was mentioned that all the study subjects belonged to the same extended family.

"Children with anxious temperaments suffer from extreme shyness, persistent worry, and increased bodily responses to stress. It has long been known that these children are at increased risk of developing anxiety, depression and associated substance abuse disorders," affirmed Dr. Ned H. Kalin, chair of psychiatry at the University of Wisconsin School of Medicine and Public Health, who led the research.

During the investigations, monkeys were subjected to a positron emission tomography (PET) scan. This scan is apparently employed in humans to evaluate the regional brain function by calculating the brain's use of glucose. Researchers found young rhesus monkeys from a large related family to have a clear pattern of inherited anxious temperament. Those monkeys who were registered with anxious temperaments revealed higher activity in the central nucleus of the amygdala and the anterior hippocampus.

While analyzing, the scientists were supposedly able to determine an individual's degree of anxious temperament by the brain activity. Activity in the amygdala and hippocampus seemed to be affected by genes and environmental factors in different ways. The scientists were seemingly provided with a brain-based understanding of the way nature and nurture can interact for ascertaining an individual's ability to acquire common psychiatric disorders.

Kalin explained, "We believe that young children who have higher activity in these brain regions are more likely to develop anxiety and depression as adolescents and adults, and are also more likely to develop drug and alcohol problems in an attempt to treat their distress."

It was uncovered that activity in the anterior hippocampus is more heritable as compared to the amygdale. The findings may lead to new ways of identifying anxiety in children. Markers of familial risk for anxiety are seemingly found by understanding modifications in specific genes promoting hippocampal function. It was concluded that alteration in the environment can probably avoid children from developing anxiety.

The research is published in the August 12 edition of the journal Nature.

Aug 16
Paracetamol may lead to asthma
Teenagers who regularly take paracetamol, the widely used over-the-counter painkiller, are more than twice as likely to develop asthma and serious allergies, a new study has claimed.
The research, involving 300,000 teenagers aged 13 and 14, found that those who had paracetamol once a month were 2.5 times as likely to have asthma than those who never took it.
And those who used it once a year were 50 per cent more likely to have asthma, it was found.
The research, carried out by a team from the Medical Research Institute of New Zealand, also linked paracetamol use to allergic nasal congestion and eczema, the Telegraph reported.
Although the researchers could not determine whether paracetamol was definitely the cause of the increased risk of asthma, eczema and nasal allergies, they suggested that
the painkiller might be interfering with the immune system and causing inflammation in the airways.
"The overall population attributable risks for current symptoms of severe asthma were around 40 per cent, suggesting that if the associations were causal, they would be of major public health significance," said lead author Dr Richard Beasley.

Aug 14
Government slams 'alarmist' superbug report
THE Union Ministry of Health and Family Welfare on Friday slammed the report that claimed a drug-resistant superbug was traced back to India, terming it as "alarmist".

Union Minister for Health and Family Welfare Ghulam Nabi Azad said it was unfair to say that the so-called "superbug NDM-1" was found only in India and Pakistan.

"It's universal and is found in the intestines of humans and animals. It's wrong to say that it's found only in India and Pakistan. They say it's found in patients who visit India and Pakistan. It was nowhere mentioned if the bacteria were there even before those persons visited India," he told reporters outside Parliament.

The Health Ministry, which was ascertaining the motives behind the study, also took strong exception to the last sentence of the report. "Concluding sentence presents a frightening picture which is not supported by any scientific data," said an official.

Minister of State for Health Dinesh Trivedi strongly objected to the naming of the "superbug" after New Delhi. "It's like HIV. As far as my information is, the first patient of HIV was in America. Can we say it originated in America? So, instead of HIV, can we say 'America NMD' or something like that?" he wondered aloud.

"Karthikeyan Kumaraswamy, one of the co-authors, has denied and disassociated himself from the report. We have to find if there's some ulterior motive of some pharmaceutical industry," he told reporters.

Karthikeyan also dismissed as hypothetical this conclusion and said the alarmist interpretations were made without his knowledge. He said there was nothing to fear about the bacteria. "Without my knowledge some of the interpretations were written in the report," said the 32-year-old research scholar of AL Mudaliar Post-Graduate Institute of Basic Medical Sciences, University of Madras.Karthikeyan co-authored with Timothy Walsh the research article published in the Lancet.

Aug 12
Laziness is 'a disease'
Laziness should be classed as "disease in its own right", say experts.

"Given the significant associated mortality and morbidity, we propose that perhaps physical inactivity should also be considered for recognition as a disease in its own right," a pair of British doctors Richard Weiler and Emmanuel Stamatakis said.

Obesity is already classed as a disease by the World Health Organisation, noted Weiler, a specialist registrar in sports and exercise at Imperial College Healthcare.

But he said obesity was often at least partially the result of a deeper cause - not doing enough exercise.

"Money is pumped at treating the symptoms of physical inactivity - at obesity, diabetes, hypertension, heart disease - but not at the root cause," said Weiler.

The evidence showed that lack of fitness was the root cause of more illness than being fat, reports telegraph.co.uk.

Weiler said recent studies showed only one in 20 people took the minimum amount of recommended exercise, but there was still "no co-ordinated plan" to tackle the problem.

Aug 12
Oil to kill vector larvae to be tested
MUMBAI: The BMC on Wednesday sent samples of various brands of an oil used to kill mosquito larvae to Haffkine Research Institute. The institute will check the product's efficacy.

The test reports are expected by Thursday. BMC's chief insecticide officer Dr Arun Bamne said that the institute will check the oil's potency. "After we get the test reports, we will procure the brand that is found to be the most effective in controlling larvae,'' he said.

Dr Ramaiya Mira, head of the Zoonosis department, Haffkine Research Institute, said that larvae and adult mosquitoes are collected and studied in small boxes named `colonies'. "Mosquito colonies to study efficacy of repellents have been used for several decades. It is an established method of testing compounds in this institute,'' she added.

A source from the institute said that the Defence Research and Development Organisation has not commissioned any study recently as reported in the media. It was actually done in 2008-09, the source added.

Aug 11
83 swine flu deaths in the country last week
The deadly swine flu seems to have made a comeback with a vengeance in the country with a whopping 83 deaths due to the disease being reported in the week ending August 8.

Maharashtra reported the maximum number of 51 deaths, 12 were reported from Karnataka and 6 from Andhra Pradesh.

Seven deaths were reported from Gujarat and one each from West Bengal, Goa and Uttar Pradesh.

Till date, samples from 1,54,259 people have been tested for influenza H1N1 in government laboratories and a few private laboratories across the country and 36,240 (23.4%) of them have been found positive.

All the 942 cases reported during the week are indigenous cases.

Aug 11
Dengue on the rise in Delhi
Dengue cases in the city climbed to 140 today after 19 more people tested positive for the virus.

"19 new patients tested positive for dengue fever. A total of 140 people have tested positive for dengue this season," MCD municipal health officer NK Yadav said.

Yadav said that the dengue cases reported at this time of the year was more in comparison to the corresponding period last year.

"Rains, Commonwealth Games and increased surveillance is the result of the increased number of cases being reported this year," Yadav said.

Municipal authorities have issued challans to many residents and organisations for breeding of mosquitoes in their premises.

Aug 10
Antidepressants In Autism: A Big Question Mark
Autism is a set of disorders ranging from inability to communicate, relate, and interact with the world around him. It is characterized by restrictive and repetitive behavior.

Sadly, no definite therapy till date has been modulated to cure this disorder completely. Antidepressants have worked for adults in some individual cases, but in children, its usage still not advisable.

According to a current study by researchers at Cochrane, autistic children could suffer from adverse side effects on taking antidepressants. There are no evidences of benefits gained due to selective serotonin reuptake inhibitors (SSRIs).

Why SSRIs Are Used To Treat Autism?

Medications do not treat the underlying neurologic cause of this disorder. Rather, it helps in managing the behavioral manifestations. It's a kind of symptomatic treatment.

Reason behind using antidepressants for autism is that SSRIs act upon serotonin, which is responsible for causing few of the psychological processes in this condition. In some people, they are known to have reduced the behavioral symptoms like irritability, depression, and aggression.

A Big No-No For Children

In several countries antidepressants are not approved by their drug authorities for children in any condition. So, its usage for autistic kids is still not recommended.

Recent Trials

In a recent trial, lead author, Dr. Katrina Williams of Sydney Children's Hospital,

University of New South Wales, Sydney, Australia, has suggested that antidepressants in children and even adults for that matter, is not recommended.

However, SSRIs for co-occurring disorders such as aggression, depression, or anxiety in autistic individuals should be made on a case by case basis.

In the research, seven trials were undertaken and it involved 271 patients in the study.

The trials evaluated fluoxetine, fenfluramine, fluvoxamine, and citalopram. To their disappointment, in five trials conducted on children, researchers found no significant benefit. In the remaining two in adults, very little improvement was observed.

According to the author, the benefits reaped from the two adult trials are still very little from recommending SSRIs in the treatment of autism.

Aug 10
Asthma inhalers 'linked to prostate cancer risk'
Researchers found that male asthma sufferers who use inhalers are up to 40 per cent more likely to develop tumours than men without the condition.

Merely having asthma increases a man's likelihood of developing prostate cancer by 26 per cent.

The Australian academics who carried out the study said the results showed the need for more research into the relationship between asthma, inhalers and prostate cancer.

They originally chose to investigate a possible link between the two conditions because both involve an inflammation of the body.

Cancer experts stressed that the new findings - based on an analysis of the medical histories of 1,179 men diagnosed with prostate cancer - were preliminary, and urged asthma sufferers to continue using their inhalers.

Dr Elaine Vickers from Asthma UK told the Daily Mail: "This research suggests their could be a weak association between asthma and prostate cancer risk.

"However even if this is true, the association is marginal, and there is no reason for men with asthma to be concerned."

The study was published in the journal Cancer Epidemiology, Biomarkers and Prevention.

Aug 09
Thyroid Disease Awareness is Very Low
One of the most common causes of fatigue and weight gain in women is hypothyroidism; but the awareness of thyroid diseases among women remains very low.

Hypothyroidism is usually manifested in young girls, but these days women are being diagnosed well into their 30s. Some of the symptoms of hypothyroidism include weight gain, chronic fatigue, anemia and irregular menstrual periods.

"The occurrence of Hypothyroidism is due to deficiency of iodine or problem with the functioning of the pituitary gland or a problem with the thyroid gland", said Dr D. C. Sharma, Associate Prof. RNT Medical College Jaipur Rajasthan.

Iodine-enhanced salt is available in order to overcome the deficiency in the diet, but women do not seem to be aware of the importance of this element. As such there is an urgent need to spread awareness of thyroid disorders among women.

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