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Oct 16
Washing hands can save 400 children everyday
Diarrhoea kills nearly 1,000 children below the age of five everyday in India, but washing hands with soap and water can save the lives of at least 400 of these kids, a UN agency said Thursday on the occasion of Global Handwashing Day.

'In India, diarrhoea is a major killer with about 1,000 children below 5 years dying every day due to diarrhoea alone. Handwashing with soap can reduce diarrhoeal deaths in children by 40 percent and is one of the most inexpensive ways to prevent diarrhoeal disease,' the Unicef said.

The agency said that proper handling and safe storage of water reduces incidences of diarrhoea by nearly half.

'Toilet use can reduce presence of diarrhoea causing agents but toilet usage in India is still very low. In 2006, toilet usage in India was 28 percent but this is showing an upward trend because of the government of India's flagship programme - Total Sanitation Campaign. Nirmal Gram Purashkar has led to more than 18,020 Panchayats being declared free of open defecation,' Unicef said.

'Yet, despite its life-saving potential, handwashing with soap is seldom practised and is not always easy to promote,' the agency added.

The UN agency said every one can make a difference in the 'Clean hands save lives' campaign. Each year, diarrhoeal diseases and acute respiratory infections are responsible for the deaths of more than 3.5 million children under the age of five.

The second annual Global Handwashing Day, being celebrated Thursday, puts the spotlight on the importance of washing hands with soap and water as one of the most effective and affordable health interventions.

Oct 16
Placebo effect starts in the spine
If you thought the placebo effect was all in the mind, think again. Scientists have solved the mystery of why some people benefit from remedies that do not contain any active pain-relief ingredients.

Research suggests that placebos work, in part, by blocking pain signals in the spinal cord from arriving at the brain in the first place.

When patients expect a treatment to be effective the brain area responsible for pain control is activated, causing the release of natural endorphins.

The endorphins send a cascade of instructions down to the spinal cord to suppress incoming pain signals and patients feel better whether or not the treatment had any direct effect.

The sequence of events in the brain closely mirrors the way opioid drugs, such as morphine, work - adding weight to the view that the placebo effect is grounded in physiology.

The finding strengthens the argument that many established medical treatments derive part of their effectiveness from the patients' expectation that the drugs will make them better.

The latest studies on antidepressants suggest that at least 75 per cent of the benefit comes from the placebo effect. GPs also observe that patients report feeling better only days after being prescribed antidepressants, even though the direct effects take several weeks to kick in.

In the study, published today in the journal Science, the spinal cords of 15 healthy volunteers were scanned using functional magnetic resonance imaging (MRI). The scan homed in on an area called the dorsal horn, which transmits pain signals coming up through the spinal cord into the pain-related areas in the brain.

During the scan, the volunteers received laser "pinpricks" to their hands. The volunteers were told that a pain-relief cream had been applied to one of their hands and a control cream to the other. But unknown to the volunteers, an identical control cream was administered to both hands.

When people believed that they had received the active cream, they reported feeling 25 per cent less pain and showed significantly reduced activity in the spinal cord pathway that processes pain.

Previously, it has been shown that placebo causes the release of natural opioids in areas of the brain involved in pain control, such as the rostral anterior cingulate cortex. However, it was not known whether the natural opioids acted on the spinal cord in the same way as artificial painkillers or whether they simply changed people's tolerance or interpretation of pain.

"We've shown that psychological factors can influence pain at the earliest stage of the central nervous system, in a similar way to drugs like morphine," said Falk Eippert, of the University Medical Centre Hamburg-Eppendorf, who led the study.

Until now, the difficulty of obtaining MRI images of the spinal cord, because of its small size and its being surrounded by airways and pulsating arteries, prevented this question from being addressed. However, advances in image processing allowed the Hamburg team to obtain high resolution scans of the region.

The advance in imaging techniques is likely to have important applications for drug development.

Pharmaceutical companies are working to develop new anaesthetic drugs that target the pain pathways in the spinal cord. Being able to image this area of the body provides a direct way of testing whether the drugs are working as intended.

Oct 15
Swine flu may cause blood clotting in lungs: Study
A Michigan study states that all those severely down with the H1N1 influenza, swine flu, are at a higher risk of developing blood clots in their lungs.

A blood clot in lungs is usually called pulmonary [pertains to lungs and respiratory system] embolism, a condition that occurs when one or more arteries in the lungs gets blocked.

The findings of the study suggested that in the wake of H1N1 virus's potential complications, medical practitioners, especially the radiologists, will have to be more aware to look closely for the risks of pulmonary embolism in severely sick patients.

Experts say that a blood clot in lung can also cause low oxygen levels in the blood and damage vital organs in the body because of lack of oxygen. The patient can feel light headed or chest pain and can also die as a result. However, they say that blood-thinning drugs can reduce the risk of death in such conditions.

Study and its findings
Researchers based at the University of Michigan, U.S., examined the medical condition
of 66 patients diagnosed with the H1N1 swine flu. Of these, 14 patients were severely ill with the H1N1 infection. Due to their severe medical condition, they had to be admitted to the intensive-care unit.

In order to identify the risk caused by the lethal H1N1 virus, all 66 patients underwent CT [a non-invasive procedure that takes cross-sectional images of the brain or other internal organs; to detect any abnormalities that may not show up on an ordinary x-ray.] scans--medical imaging method using computer processing--to look for any complications caused by the pandemic flu.

Reports of the CT scans detected pulmonary embolisms in five of the 14 intensive-care unit patients. However, the researchers maintained that initial standard chest X-rays were normal in more than half of the patients with H1N1 infections.

"These findings indicate that imaging studies would have to be repeated in severely ill patients to monitor disease progression," said study co-author Dr. Ella Kazerooni, director of the University of Michigan's division of cardiothoracic radiology. "It's important to heighten awareness not only among the radiologists, but also among the referring clinicians."

The researchers noted that more sophisticated CT scans are needed to diagnose the potentially fatal condition since the standard chest X-rays cannot effectively scan the lungs.

A report by World Health Organisation (WHO) also warns that the H1N1 might return for a second strike in winters in a more mutated form, infecting the lungs deeper this time.

Oct 15
Green tea may curb risk of some cancers
Drinking green tea may lower your risk of developing certain blood cancers, but it will take about 5 cups a day, according to a study from Japan.

Drinking green tea has been associated with lower risk of dying and heart disease deaths, Dr. Toru Naganuma, at Tohoku University School of Medicine in Sendai, Japan told Reuters Health in an email correspondence.

The current study, Naganuma said, suggests drinking green tea may have a favorable effect "for particular cancers."

After gathering information on the diets and green tea drinking habits of a large group of Japanese adults aged 40 to 79 years old, Naganuma and colleagues followed the group for development of blood and "lymph system" cancers. The lymph system is a major component of the body's immune system.

The 19,749 men and 22,012 women who participated in the study had no previous history of cancer, Naganuma and colleagues note in the American Journal of Epidemiology.

During 9 years of follow up, 157 blood, bone marrow, and lymph system cancers developed in the study group.

Naganuma's team found that the overall risk for blood cancers was 42 percent lower among study participants who drank 5 or more, versus 1 or fewer, cups of green tea daily.

Drinking 5 or more cups of green tea daily was also associated with 48 percent lower risk for lymph system cancers.

These associations held up in analyses that allowed for age, gender, education, smoking status and history, alcohol use, and fish and soybean consumption.

The researchers also observed reduced risk for blood-related cancers among obese study participants, who are "considered to have higher risk of these cancers," Naganuma said.

The investigators say further studies are needed to confirm the health benefits of drinking green tea, and to determine whether daily consumption might prevent certain cancers.

Oct 15
UNICEF, WHO launch report on 2nd greatest killer of children
Despite the existence of inexpensive and efficient means of treatment, diarrhoea kills more children than AIDS, malaria and measles combined, according to a report issued here Wednesday by the UN Children's Fund (UNICEF) and the World Health Organization (WHO).

The report, titled "Diarrhoea: Why Children Are Still Dying and What Can Be Done," includes information on the causes of diarrhoea,data on access to means of prevention and treatment, and a seven-point plan to reduce diarrhoea deaths.

"It is a tragedy that diarrhoea, which is little more than an inconvenience in the developed world, kills an estimated 1.5 million children each year," said UNICEF Executive Director, Ann M.Veneman. "Inexpensive and effective treatments for diarrhoea exist, but in developing countries only 39 per cent of children with diarrhoea receive the recommended treatment."

Margaret Chan, Director-General of WHO, said: "We know where children are dying of diarrhoea. We know what must be done to prevent those deaths. We must work with governments and partners to put this seven-point plan into action."

Diarrhoea is a common symptom of gastrointestinal infection, which can have a variety of sources. However just a handful of organisms are responsible for most acute cases of diarrhoea and one, Rotavirus, is responsible for more than 40 per cent of all diarrhoea-related hospital admissions of children under five. A new vaccine for Rotavirus has been found to be safe and effective but is still largely unavailable in most developing countries.

Though most episodes of childhood diarrhoea are mild, acute cases can lead to significant fluid loss and dehydration. This dehydration can lead to death unless fluids are quickly replaced.

Oral rehydration therapy is the cornerstone of fluid replacement and the new low-osmolarity formula of oral rehydrationsalts (ORS) is a simple, inexpensive and life-saving remedy that prevents dehydration in children suffering diarrhoea.

Some 88 percent of diarrhoeal deaths worldwide are attributable to unsafe water, inadequate sanitation and poor hygiene. As of 2006, an estimated 2.5 billion people around the world were not using adequate sanitation facilities, and about 1 in 4 people in developing countries practised open defecation.

Access to clean water and good hygiene practices are extremely effective in preventing childhood diarrhoea. Hand washing with soap has been shown to reduce the incidence of diarrhoeal disease by over 40 percent, making it one of the most cost-effective interventions for reducing child deaths caused by this neglected killer. Thursday October 15 is annual Global Handwashing Day when millions of children and adults in over 80 countries will take part in activities to highlight this key intervention.

The overall health and nutrition of children is also critical to their susceptibility to diarrhoea and the damage it can cause. Undernourished children are at higher risk of suffering more frequent, severe and prolonged episodes of diarrhoea, and repeated bouts of diarrhoea also place children at greater risk of worsening nutritional status.

The seven point plan to save the lives of children stricken by diarrhoea includes two treatment and five prevention elements.

The two treatment elements are:

1. fluid replacement to prevent dehydration; and

2. zinc treatments, which decrease the severity and duration ofthe attack.

The five prevention elements are:

1. immunization against rotavirus and measles;

2. early and exclusive breastfeeding and vitamin A supplementation;

3. handwashing with soap;

4. improved water supply quantity and quality; and

5. promoting community-wide sanitation.

Campaigns targeting childhood diarrhoea in the 1970s and 1980s achieved success by educating caregivers and scaling up oral rehydration therapy to prevent dehydration.

The campaigns delivered promising results but following that success, focus shifted to other health problems. There is now an urgent need to shift attention and resources back to treating and preventing diarrhoea, UNICEF officials said.

Oct 14
Risk factors for catching cancer
Cancer used to be thought one of those diseases that you couldn't get from anyone else. If you got it, it was the fault of your genes. But as time has gone on, it has become obvious that lifestyle is at least as big a factor, and that alongside drinking, smoking and eating too much, which can all be implicated, the viruses that we pass from one to another can raise our risk.

Transmission of cancer from mother to child is incredibly rare and has now been shown to have genetic triggers. The baby's immune system should have blocked the cancer, but it did not recognise the enemy. As far as we know, there was nothing in the mother's lifestyle that made cancer more likely.

But usually cancer is a combination of genetic propensity and environmental circumstances. Risk factors for many cancers include obesity. Cervical cancer is caused by a virus - the human papillomavirus (HPV), for which we now have a vaccine. HPV is sexually transmitted. But most women come into contact with it at some point in their lives and most women clear it from their bodies without knowing it. Only in a very small proportion of cases does it cause cancer.

Viruses may well trigger other cancers. There are theories around leukaemia and childhood infections. But Mel Greaves of the Institute of Cancer Research, who led the present study, earlier showed through analysing heel-prick blood from newborns that many already have cell damage that can lead to cancer. Cancer cannot be caught like a cold. The most positive message of the new study is that it affects some people whose immune systems are not working as well as they should. That could lead to treatments to boost the immune systems of people who are known to be at genetic risk or who have already had cancer.

Oct 14
Exercise does make you feel sexier
Feeling lighter now that you have been gymming for a week? Convinced the pounds have started melting, improving your looks? It's all in your mind.

It's the exercise and not higher levels of fitness that is improving your body image, says a study by Heather Hausenblas, an exercise psychologist from the University of Florida, and her student Anna Campbell. After analysing 57 studies to see how physical activity impacts an individual's body image, they found even if exercise didn't improve fitness levels, it did make people feel better about themselves.

What's more, it wasn't how hard you exercises, or how much but just that you did.

One study showed no difference in body image improvement between people who exercised minimum 30 minutes a day, five days a week and those who didn't. "We would have thought that people exercising this amount would have felt better about their bodies than those who did not work out as much," Hausenblas said.

In another study, women were found to feel slightly better about their bodies than were men if they sweated it out. "We believed the gap would be much bigger, but what could be coming into play is the rise of body image issues among men. We're seeing more media portrayals of the ideal physique for men rather than the overriding emphasis on women we did in the past," Hausenblas said.

And the older you get, the better exercise impacts you psychologically perhaps because older people are more concerned about their bodies as physical activity among them is lower than younger people.

Low body image is becoming something of an epidemic across the world due to unrealistic images being flashed in the media. "Body dissatisfaction is a huge problem in our society and is related to all sorts of negative behaviour including yo-yo dieting, smoking, taking steroids and undergoing cosmetic surgery. It affects men and women and all ages, starting with kids who are as young as five years old saying they don't like how their bodies look," said Hausenblas. The analysis has been detailed in Journal of Health Psychology.

If you don't like what you see in the mirror, time to switch to the mirror in the gym. Mind matters.

Oct 14
TCD study could help battle against blindness
IMPORTANT RESEARCH at Trinity College Dublin has opened up the possibility of new drug treatments that could halt progressive blindness.

The discovery, which helps specialised drugs penetrate through to their target tissues, may also prove valuable in neurological conditions such as Alzheimer's.

The work comes from the Smurfit Institute of Genetics' Ocular Genetics Unit. Dr Matthew Campbell led the research with Prof Peter Humphries and involved other Trinity colleagues.

They have developed a way to help drugs cross the "blood-retina barrier", the natural seal that keeps blood-borne substances away from the retina.

There is a similar blood-brain barrier that must be overcome to get useful drugs into brain tissues.Almost all of the drugs that look promising for the treatment of degenerative diseases of the retina including retinitis pigmentosa, age-related macular degeneration and retinal damage caused by diabetes cannot reach the retina because of the barrier, Dr Campbell said yesterday.

The new technique, however, temporarily opens up the blood-retina barrier. It uses small pieces of genetic material that temporarily interferes with the barrier and has successfully been shown to work with mice.

Only drugs that have a small molecular size are able to pass through, but unwanted things circulating in the blood such as antibodies or albumin are still kept out, Dr Campbell said.

It so happens that the molecular size of drugs that seem suited to these degenerative diseases is also small, allowing them to pass through the retinal barrier. It will allow rapid testing of drugs that might be useful in these diseases.

Importantly, the technology could also be adapted for use in neuro-degenerative conditions, Dr Campbell added. Diseases of interest in this case include Alzheimer's but also multiple sclerosis. It could also be of use to help drug delivery for untreatable brain tumours, he believes.

Oct 13
Kids' Tummy Aches Eased by Imagination
Children can be taught to use their imagination to tackle frequent bouts of stomach pain, research shows.

A relaxation-type CD, asking children to imagine themselves in scenarios like floating on a cloud led to dramatic improvements in abdominal pain.

The US researchers said the technique worked particularly well in children as they have such fertile imaginations.

It has been estimated that frequent stomach pain with no identifiable cause affects up to one in five children.

The research, published in the journal Pediatrics, follows on from studies showing hypnosis is an effective treatment for a range of conditions known as functional abdominal pain, which includes things like irritable bowel syndrome.

In this study, the children had 20 minute sessions of "guided imagery" - a technique which prompts the subject to imagine things which will reduce their discomfort.

One example is letting a special shiny object melt into their hand and then placing their hand on their belly, spreading warmth and light from the hand inside the tummy to make a protective barrier inside that prevents anything from irritating the belly

The researchers, from the University of North Carolina and Duke University Medical Center, said a lack of therapists led them to the idea of using a CD to deliver the sessions.

In all 30 children aged between six and 15 years took part in the study - half of whom used the CDs daily for eight weeks and the rest of whom got normal treatment.

Among those who had used the CDs, 73.3% reported that their abdominal pain was reduced by half or more by the end of the treatment course compared with 26.7% in the standard care group.

In two-thirds of children the improvements were still apparent six months later.

Anxiety

It is not clear exactly how the technique works but studies have shown it is partly about reducing anxiety but there is also a direct effect on the pain response.

Some researchers think hypnosis-like techniques reduce "hypersensitivity" in conditions such as irritable bowel syndrome.

Study leader Dr Miranda van Tilburg said it was especially exciting that the children were able to use the technique on their own.

"Such self-administered treatment is, of course, very inexpensive and can be used in addition to other treatments, which potentially opens the door for easily enhancing treatment outcomes for a lot of children suffering from frequent stomach aches.

"Children are very good at using their imagination - when you use this in adults you have to overcome a barrier first."

Professor David Candy, a consultant paediatric gastroenterologist at Western Sussex Hospitals, said his team had tried hypnosis in a small group of children with severe abdominal pain problems and had 100% success rate.

He added they are now keen to try the guided imagery technique to see if they can replicate the US findings.

"There is really a dearth of information on how to manage children with abdominal pain and it's a very common problem which keeps children out of school."

Oct 13
Raw Fish Spread Liver Cancer
Uncooked fish can cause human liver cancer, but most sushi lovers need not worry since the condition comes only from eating certain freshwater fish.

The human liver fluke, a freshwater parasite endemic to areas of Thailand, Japan, and Siberia, triggers human liver cancer by creating harmful cell mutations, encouraging tumor growth, and stopping normal cell death, according to a study released yesterday in the journal PLoS Pathogens.

The research could help prevent millions of people from developing liver cancer.

The International Agency for Research on Cancer "has classified Opisthorchis viverrini as a Class One carcinogen," said Sutas Suttiprapa, a scientist at George Washington University and a co-author of the PLoS Pathogens papers.

"I think that over the next year or next few years there will be a big campaign to treat and give these people some knowledge to stop eating raw fish."

There are actually three species of microscopic human liver fluke. O. viverrini is endemic to streams and lakes in Thailand, Laos, and Cambodia and was the actual species of fluke tested by the scientists. Another fluke lives in Siberia, and yet another is found in Japan and Korea.The parasite is only found in freshwater however, so eating sushi from the ocean is safe to eat.

Like many parasites, the human liver fluke has a complicated life span. An egg is first released from the human host. A snail eats the egg, which hatches and begins to develop.

Eventually a free swimming larvae emerges from the snail and attaches to the skin of a freshwater fish. When a human eats the fish raw, or as most people in Thailand are infected, by eating a delicacy of fermented fish, the parasite emerges from the small intestine and takes up residence inside the liver.

Once in the liver three things happen that eventually lead to cancer. First, the body tries to kill the fluke by producing free oxygen radicals. The fluke is largely immune from these attacks, however, so the radicals rebound, enter the body's own liver cells, and mutate human DNA.

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