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Nov 17
Parasitic worms 'treat diarrhoea'
Chronic diarrhoea could be treated using parasitic worms, a study of monkeys has suggested.

Research published in PLOS Pathogens, suggests the treatment restores gut bacteria to a healthy state.

Other work in mice has already suggested conditions such as ulcerative colitis could be treated in this way.

A UK expert said parasitic worms were being investigated for a range of conditions, including multiple sclerosis and allergies.
Captivity

Inflammatory bowel diseases, like colitis, are often fuelled by a wrongly targeted response by the immune system to gut bacteria.

Such diseases are more common in developed countries - and scientists suggest this is because people in developing countries have more exposure to parasitic worm (helminth) infections and therefore have a natural protection that has evolved as people and worms learnt to co-exist.

Recent studies have used parasitic worms to successfully treat inflammatory bowel disease in humans, but it is unclear exactly how they do this.

This latest study looked at monkeys because young macaques kept in captivity often develop chronic diarrhoea that can be hard to treat.

Five macaques with diarrhoea were treated with parasitic worms called whipworms.

Tissue samples were taken before and after treatment and it was found the balance of gut bacteria was restored to required levels.

And four out of five animals had less diarrhoea and started to gain weight.

Dr P'ng Loke, of the New York University Langone Medical Center, who led the study, said: "The idea for treating colitis with worms is not new, but how this therapy might work remains unclear.

"Our findings suggest that exposure to helminths may improve symptoms by restoring the balance to the microbial communities that are attached to the intestinal wall."

The researchers now plan a study in humans to look at how pig helminth eggs might help alleviate the symptoms of colitis.
Compensating

Prof Graham Rook, of the centre for clinical microbiology at University College London, said a number of research teams were investigating the effects of parasitic worms in various conditions.

"This is not part of the hygiene hypothesis [which says exposure to bacteria strengthened the immune system]. It's the "old friends" hypothesis.

"We co-evolved with these things, so they had to be tolerated. We found ways of suppressing the immune systems, and in some way have come to depend on them."

And he said the field of research as a whole would be "hugely significant".

He added: "With helminths, if you get the dose right, you can probably live with worms and not have symptoms.

"But it may well be there is going to be a battery of molecules you could be dosed with to compensate for not meeting our 'old friends'."

Nov 17
Exercise could help ward off bone disease in teens
Teenagers have been urged to play sports or run for at least three hours a week to counteract the potential damage to their bone health caused by prolonged spells of sitting.

An international team, including an expert from the University of Exeter, has found evidence that adolescents who spend long periods engaged in certain sedentary activities are more likely to have low bone mineral content in parts of the body where it can be an indicator of the risk of developing osteoporosis.

In the research, the team found that studying put girls at particular risk, while for boys leisure internet use posed the greatest threat.

Scientists found that participating in at least three hours of certain sports could significantly reduce the threat in girls. The study found evidence of the benefits of high-intensity sports where the participant is on their feet, such as football, basketball, netball or running.

Scientists have previously studied the impact of an inactive lifestyle on problems such as obesity or heart defects, but this is one of the first studies analysing the effects of different sedentary behaviours on bone health in the critical development period of adolescence.

"Clearly we are not telling girls not to study. It is a fact of modern life that teenagers spend more time engaged in deskbound or sitting activities, but our research is one of the first to identify a connection between this behaviour in adolescents and low levels of bone mass in key regions of the body," said Dr Luis Gracia Marco of the University of Exeter, who led the research.

"It is already well-known that an inactive lifestyle has implications for young people, such as obesity and heart diseases. Combined with that, our findings emphasise the need for exercise, and we hope it will give some focus for young people and their parents to ward off any health problems later in life," Dr Marco added.

The research was carried out in collaboration with scientists from the University of Zaragoza, the University of Granada, the Spanish National Research Council (CSIC), and the University of Sao Paulo, Brazil. It was supported by the European community Sixth RTD Framework Program, as well as with a grant from Fundacion Cuenca Villoro.

The research assessed the lifestyles of 359 Spanish adolescents participating in the Healthy Lifestyle in Europe by Nutrition in Adolescence Study. It examined bone mineral content in the femoral neck region of the hip, which is a critical area for diagnosing osteoporosis.

The research team looked at the impact of different types of sitting activity, including watching television and playing computer games. The strongest connection between deskbound behaviour and low bone mineral content was found in girls' hips, which is where most fractures occur. It was linked to study time, but regardless of how much time they spent studying, the risk was significantly reduced if they spent at least three hours each week participating in high-intensity upright sport.

Internet leisure use was found to negatively affect whole body bone mineral content in boys.

Dr Gracia Marco said: "More research is needed to establish exactly why there are differences between the two genders, and why these types of activity are particularly damageing to teenage boys and girls, but we can speculate that it is linked to how long they remain in the same position.

The research was published in PubMed.

Nov 16
Moderate drinking during pregnancy can affect child's IQ
Children who are exposed to alcohol while in the womb may have lower IQ, a new study led by researchers from the universities of Bristol and Oxford has suggested.

The study that used data from over 4,000 mothers and their children in the Children of the 90s study (ALSPAC) found that even moderate amounts of alcohol consumption during pregnancy can have an effect on future child's intelligence.

This study, believed to be the first substantial one of its kind, used genetic variation to investigate the effects of moderate (less than1-6 units of alcohol per week) drinking during pregnancy among a large group of women and their children. Since the individual variations that people have in their DNA are not connected to lifestyle and social factors, the approach removes that potential complication.

Four genetic variants in alcohol-metabolising genes among the 4,167 children were strongly related to lower IQ at age eight. The child's IQ was on average almost two points lower per genetic modification they possessed.

But this effect was only seen among the children of women who were moderate drinkers. There was no effect evident among children whose mothers abstained during pregnancy, strongly suggesting that it was the exposure to alcohol in the womb that was leading to the difference in child IQ. Heavy drinkers were not included in the study.

When a person drinks alcohol, ethanol is converted to acetaldehyde by a group of enzymes. Variations in the genes that 'encode' these enzymes lead to differences in their ability to metabolise ethanol. In 'slow metabolisers', peak alcohol levels may be higher and persist for longer than in 'fast metabolisers'.

It is believed that the 'fast' metabolism of ethanol protects against abnormal brain development in infants because less alcohol is delivered to the fetus, although the exact mechanisms are still unclear.

"Our results suggest that even at levels of alcohol consumption which are normally considered to be harmless, we can detect differences in childhood IQ, which are dependent on the ability of the foetus to clear this alcohol. This is evidence that even at these moderate levels, alcohol is influencing foetal brain development," the report's main author, Dr Sarah Lewis, said.

Dr Ron Gray from the University of Oxford who led the research added: "This is a complex study but the message is simple: even moderate amounts of alcohol during pregnancy can have an effect on future child intelligence. So women have good reason to choose to avoid alcohol when pregnant."

The study has been published in PLOS ONE.

Nov 16
Vitamin D in pregnancy may prevent multiple sclerosis
Researchers said they have found evidence that Vitamin D supplements for pregnant women in the world's colder, darker countries may stave off multiple sclerosis (MS) in their offspring.

The finding adds to a growing body of work showing a link between low Vitamin D levels and the debilitating disease, which sees the immune system attacking the body's own nerve fibres.

Data on more than 1,50,000 MS patients born in places north of 52 degrees, revealed a heightened risk for those born in April a month preceded by a long period without sunlight, said a paper in the Journal of Neurology, Neurosurgery and Psychiatry.

Of the total, 13,300 were born in April compared to 11,600 in November a lower-risk month after summer in the northern hemisphere, British researchers wrote.

"Month of birth has a significant effect on subsequent MS risk," they said.

"This is likely to be due to ultraviolet light exposure and maternal Vitamin D levels.

They added, though, it could also be "any factor that varies in a similar seasonal and latitudinal manner".

The data was taken from individuals born between 1930 and 1980, from studies done in Britain, the United States, Italy, Israel, Finland, Scotland, Sweden and Canada parts of which see little sunlight between the months of October and March.

About 1,00,000 people in Britain and about 4,00,000 in the United States are believed to suffer from MS, a disease that affects vision, movement, balance, sensation, bladder control and eventually also memory and thinking. There is no cure.
Study co-author Sreeram Ramagopalan from the Queen Mary University of London said the findings amounted to an added MS risk of 5 percent for people born in April about five extra births per million.

"Pregnant mothers need to ensure they are Vitamin D replete at all times," Ramagopalan said in an email exchange.

"Because Vitamin D deficiency is a massive problem at the moment due to living at high latitudes and lifestyle changes (wearing sunscreen etc), mothers may need to take several thousand international units of Vitamin D3 to become Vitamin D replete."

Humans need Vitamin D, which our bodies produce from exposure to sunlight or extract from food, for healthy bones.

Suspected links between a lack of vitamin D and an increased risk of death, including from heart disease and certain types of cancer, have been the subject of medical research for several years.

Researchers have also focused on its possible role in MS.

"It is thought that maternal Vitamin D levels during pregnancy affect the immune status of the developing foetus, and hence modulates subsequent MS risk," wrote the authors.

North of 52 degrees latitude lies the northern parts of England, the Scandinavian countries, and most of Russia and Canada.

No studies from the southern hemisphere were included in the analysis.

Nov 12
Excessive clean homes can cause peanut allergies in kids
Keeping your home obsessively clean could make your children develop a life-threatening peanut allergy, a new study has claimed.

The research found that children from a more affluent background were twice as likely to have a peanut allergy than their poorer counterparts.

Peanut allergy commonly causes breathing problems, but occasionally results in fatal anaphylactic shock.
The number of British children with the condition, which can be fatal in extreme cases, is believed to have doubled in the past 20 years, the 'Daily Mail' reported.

The increase is sharpest among the children of wealthy middle-class parents who keep their homes excessively clean and dirt-free.

Scientists say the findings support the theory that youngsters from wealthier backgrounds enjoy an excessively clean lifestyle, leaving their developing immune systems unfamiliar with many germs.

When they are later exposed to new irritants, including harmless foods such as nuts, their body is more likely to have an allergic reaction.

The study examined 8,306 patients, 776 of which had some form of reaction to peanuts.

"Overall household income is only associated with peanut sensitisation in children aged one to nine years," said lead author of the study, Dr Sandy Yip.

"This may indicate that development of peanut sensitisation at a young age is related to affluence, but those developed later in life are not," he said.

Researchers also found that peanut allergy was generally higher in males and racial minorities.

"While many children can develop a tolerance to food allergens as they age, only 20 per cent will outgrow a peanut allergy," said American College of Allergy, Asthma, and Immunology (ACAAI)president Dr Stanley Fineman.

Nov 12
100 million deaths due to smoking in last 100 years in India
A new study has estimated that 100 million people have died due to smoking in India over the last 100 years, and the worst apparently is yet to come. Nearly 4.52 trillion cigarettes and 40.3 trillion beedis have been produced in 100 years, between 1910 and 2010 in India, according to a new study published in the journal Current Science. And in an even more shocking revelation, the study has estimated nearly a 100 million premature deaths in India, as a result of smoking in the last 100 years.

The study found that in the first 50 years between 1910 and 1960, more than 5.5 trillion beedis and 52.7 billion cigarettes were manufactured and smoked. Researchers believe these smokers mostly died in a span of the next 40-50 years.

But researchers have warned that the larger part of the epidemic is yet to occur. That is because in the last 50 years, from 1960 to 2010, smoking rates went up four times - and these are estimated to cause a large number of deaths in the next 50 years.

Study Author Dr Nevin Wilson said, "Smoking is estimated to cause 78.8 million deaths till 2050." Another study author Dr PC Gupta said that if this continues, we will see more than 200 million deaths within this century.

Presently, India has 111 million smokers, but public health experts warn of a larger health epidemic in the 164 million Indian smokeless tobacco users. Gutka is known is causing 90 per cent of all oral cancers and is responsible for the maximum number of young heart attacks, Gupta said.

Nov 10
Contraceptive pills can help stave off dementia
Contraceptive pills could prevent young women from developing dementia later in life, a new study has claimed.

Middle-aged women who had been on the drug when they were younger performed far better in memory tests than those who had never taken it.

Experts think that the key hormone in the pill, oestrogen, prevents the arteries from hardening, which increases the blood supply to the brain, helping stave off the disease, the 'Daily Mail' reported.
Scientists, for some years, have known that Hormone replacement therapy (HRT), which also contains oestrogen, seems to protect against dementia.

However, little was known about the potential benefits of the contraceptive pill.

US scientists looked at 261 women aged 40 to 65 who were surveyed on their health. They conducted a series of tests on their memory, including naming certain objects and listing as many words as they could on a given subject.

Researchers from the University of Wisconsin found that women who had taken the contraceptive pill performed significantly better in some of the tests.

They also found that the longer the women had been on the contraceptive pills, the higher their scores.

Although the study did not directly look at the risks of dementia, adults whose brains are sharper in middle age are thought to be far less at risk of the illness.

Experts think that oestrogen, the main hormone in the Pill, helps maintain the function of the brain in two ways.

Firstly, they believe it prevents the arteries from becoming blocked, which keeps a steady flow of blood to the brain. They also believe it may encourage the growth of certain cells in the brain and spinal cord.

"Our analysis indicated that hormonal contraceptive use may have a protective cognitive (memory) effect, even years after use is discontinued. This is especially true in subjects with a longer duration of use," lead researcher Kelly Egan, said.

The contraceptive pill may been shown to protect against some cancers such as ovarian and bowel, however, it is thought to raise the risk of breast tumours, report said.

Nov 10
Diwali special: Top 5 home remedies for perfect glow
Look at that girl, isn't she beautiful and her skin, oh! She has that perfect glow. Can't I have a glowing skin like her? Do thoughts like these make you jealous? Everyone wants to grab that attention and look their best during the festive season. But, thanks to our stressful lives, faulty eating habits, pollution and most of all our lethargy, we neglect to take care of ourselves. A healthy skin and perfect radiance tops the wish list of every woman irrespective of her age and profession.

But, don't worry, this Diwali, we bring before you the best home remedies that will work wonders for skin while being cost effective too.


Home tips for glowing skin:

- Egg white and honey face mask: It works wonders, trust me. All you have to do is first mix one egg white with 1 tbsp of honey and after this, apply it evenly over your face extending it to the neck. All you get to see is a glowing bright skin.

- Milk and honey mask: It is one of the best formulas to get that instant glow. Take a spoonful of honey and mix at least half cup of fresh milk in it. Now, apply this wonder mask on your face and see the amazing results.

Home tips for chapped lips:

- Desi Ghee, yes! which we resist to eat is actually the best moisturizer for those chapped lips.

- Applying a little amount of coconut oil is very effective in treating dry lips.

- One can also apply a small amount of paste containing honey mixed with a little Vaseline on dry lips to retain the lost moister of your lips.

Home tips for treating under eye circles:

- Apply cucumber juice for say 10-15 minutes and then wash off your eyes with plain water. This will help in reducing the stress of your eyes.

- Applying a mixture of potato juice with cucumber juice proves to be quite effective in treating puffiness of eyes along with dark circles.

- Cooled tea bags too help a lot in revitalizing the area under your eyes.

Home tips for those dry and black elbows and knees:

- Cut a lemon and then apply its juice on the darkened area of your elbow and knee and see the change. Do it at least twice a week for most effective results.

- Applying a mixture of sugar with honey and scrubbing it on your elbows and knees twice a week is also helpful.

- Another tip is to mix 1 tbsp of coconut oil in lemon juice and the applying it.

Home tips to treat cracked heels:

- For treating cracked heels, apply a mixture of candle wax and mustard oil and leave it on overnight to see the difference.

- Cracked heel is a common problem but trust me, sesame oil works wonders. Apply it on your cracked heels before going to bed and you will fall in love with your feet the very next day.

- Applying pulp of ripe banana on the affected area helps a lot in fast healing.

So, go on ladies make the most of these tips and shine like a 'diya' this diwali from tip-to-toe.

Nov 09
Black Tea Linked to Lower Diabetes Risk
Drinking black tea may help protect against type 2 diabetes, but more study is needed to confirm an association.

When researchers analyzed data from 50 countries, they found that the rate of diabetes was lowest in countries where people drank the most black tea.

Type 2 diabetes rates have skyrocketed worldwide in recent decades. It's projected that by 2030 there will be more than 900 million people across the globe with diabetes or with a high risk for developing it.

When researchers used a mathematical model to estimate the impact of drinking black tea on a number of health conditions, they found a link to just one -- diabetes.

Of the countries included in the analysis, black tea drinking was highest in Ireland, the U.K., and Turkey. It was lowest in South Korea, Brazil, and China.

Researcher Ariel Beresniak, MD, PhD, of the mathematical research group Data Mining International in Geneva, Switzerland, says the study shows a consistent relationship between black tea drinking and type 2 diabetes risk. But this study does not prove a cause and effect relationship.

Black tea may protect against diabetes, Beresniak says, but more research is needed to prove this.

"You certainly can't say that on the basis of this study alone, but the findings are consistent with previous studies that have also suggested a link," he says.

The new study was published today in the journal BMJ Open.

Nov 09
Protein level in blood can indicate diabetes risk
Researchers from Sweden have identified a protein in blood that can indicate who is at risk of diabetes at an early stage, thereby reducing the chances of the disease to damage areas like blood vessels and eyes because of late diagnosis.

"We have shown that individuals who have above-average levels of a protein called SFRP4 in the blood are five times more likely to develop diabetes in the next few years than those with below-average levels," Anders Rosengren, a researcher at the Lund University Diabetes Centre (LUDC), who led the work on the risk marker, said.

It is the first time a link has been established between the protein SFRP4, which plays a role in inflammatory processes in the body, and the risk of type 2 diabetes.

Studies at LUDC, in which donated insulin-producing beta cells from diabetic individuals and non-diabetic individuals have been compared, show that cells from diabetics have significantly higher levels of the protein.

It is also the first time the link between inflammation in beta cells and diabetes has been proven.

"The theory has been that low-grade chronic inflammation weakens the beta cells so that they are no longer able to secrete sufficient insulin. There are no doubt multiple reasons for the weakness, but the SFRP4 protein is one of them," Taman Mahdi, main author of the study and one of the researchers in Rosengren's group, said.

The level of the protein SFRP4 in the blood of non-diabetics was measured three times at intervals of three years.

Thirty-seven per cent of those who had higher than average levels developed diabetes during the period of the study. Among those with a lower than average level, only nine per cent developed the condition.

"This makes it a strong risk marker that is present several years before diagnosis. We have also identified the mechanism for how SFRP4 impairs the secretion of insulin. The marker therefore reflects not only an increased risk, but also an ongoing disease process," Rosengren said.

The marker works independently of other known risk factors for type 2 diabetes, for example obesity and age.

"If we can point to an increased risk of diabetes in a middle-aged individual of normal weight using a simple blood test, up to ten years before the disease develops, this could provide strong motivation to them to improve their lifestyle to reduce the risk," Rosengren said.

"In the long term, our findings could also lead to new methods of treating type 2 diabetes by developing ways of blocking the protein SFRP4 in the insulin-producing beta cells and reducing inflammation, thereby protecting the cells," he said.

The findings have been published in the journal Cell Metabolism.

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