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Dec 15
Longer life spans scarred by more sickness
Longer life spans are scarred by more number of years of sickness than before, reveals a new study.

Indeed, a 20-year-old today can expect to live one less healthy year over his or her life span than a 20-year-old a decade ago, even though life expectancy has grown.

From 1970 to 2005, the probability of a 65-year-old surviving till age 85 has doubled from about a 20 percent chance to a 40 percent chance, reports the Journal of Gerontology.

But new research from Prof Eileen Crimmins, gerontologist at the University of Southern California, and Hiram Beltran-Sanchez, Crimmins` junior colleague, shows that the period spent with a serious disease or loss of functional mobility has actually increased in the last few decades.

`There is substantial evidence that we have done little to-date to eliminate or delay disease while we have prevented death from diseases,` Crimmins explained, according to a Southern California release.

`At the same time, there have been substantial increases in the incidences of certain chronic diseases, specifically, diabetes.`

A 20-year-old male in 1998 could expect to live another 45 years without at least one of the leading causes of death: cardiovascular disease, cancer or diabetes.

The number fell to 43.8 years in 2006, the loss of more than a year. For young women, expected years of life without serious disease fell from 49.2 years to 48 years over the last decade.

At the same time, the number of people who report lack of mobility has grown, starting with young adults.

Functional mobility is defined as the ability to walk up 10 steps, walk a quarter mile, stand or sit for two hours, and stand, bend or kneel without using special equipment.

Dec 14
'42 lakh persons in TN affected by diabetes'
Tamil Nadu might be at the top of healthcare provider's list, but it also happens to have the high number of diabetics, shows a study conducted by the Madras Diabetes Research Foundation, here, supported by the Indian Council of Medical Research, released on Monday.

The study on prevalence of diabetes in Tamil Nadu shows that 9.8 per cent of the population in the State are diabetic, which amounts to 42 lakh. The urban Tamil Nadu has 13.5 per cent and rural parts 6.9 per cent.

Thirty lakh people in the State are in the high-risk pre-diabetes stage, with a break-up of 8 per cent in urban areas and 6.4 per cent in rural belt.

R M Anjana, diabetologist and ICMR-INDIAB, who headed the research team at the Madras Diabetes Research Foundation, said that the study was the first representative on the prevalence of type 2 diabetes mellitus and pre-diabetes from Tamil Nadu. About 1,200 from urban areas and 2,800 from rural areas were studied in a door-to-door survey.

The study also found that abdominal obesity in the State was as much as 22.4 per cent in males and 35.3 per cent in females. In addition, the report revealed that 27.8 per cent of Tamil Nadu population have hypertension and 20.1 per cent have hyper cholesterolemia, which were pre-disposing factors to diabetes.

The study, which also assessed the level of diabetes control, showed that nearly one-third have good control of diabetes, one-third have an average control and one-third have poor control.

Dec 14
ADHD and Reading Disability Occur Together in Children
A new study has pointed out that Attention Deficit Hyperactivity Disorder (ADHD) and developmental reading disability (RD) mostly occur together in children.

If a child is experiencing trouble with reading, symptoms of ADHD are often also present. However, the reason for this correlation remains unknown.

The new study has suggested that the childhood disorders have common genetic influences, which may also lead to slow processing speed - the brain taking longer to make sense of the information it receives.

The researchers looked at 457 pairs of twins from the Colorado Learning Disabilities Research Center (CLDRC) twin study - an ongoing study of the causes of reading disabilities, ADHD, and related disorders.

Erik Willcutt and colleagues compared groups of participants with and without RD and ADHD, using a variety of tests to measure general cognitive ability, processing speed, reading and language skills, and then analysed results from pairs of twins within those groups to determine the genetic causes of any correlations.

The findings showed that both RD and ADHD are complex disorders, influenced by many factors; ADHD on its own was associated with a reduced ability to inhibit responses to stimuli, while reading disabilities were associated with various weaknesses in language and memory.

Dec 13
WHO endorses new test for detecting TB in less than 2 hours
Early detection & prevention: Molecular Medicine. www.siemens.com/answers

Dr. David Alland, chief of the Division of Infectious Disease at UMDNJ-New Jersey Medical School, is the driving force behind the rapid tuberculosis test that received World Health Organization endorsement this week.

The test, which uses DNA technology to diagnose tuberculosis in less than two hours, will be widely distributed to countries around the world.

WHO says the new test "represents new hope for the millions of people who are at the highest risk of TB and drug-resistant disease."

The testing technology that it replaces, which is 125 years old, is far less reliable and requires three months to produce a diagnosis.

The quicker and more accurate diagnoses produced by Dr. Alland's test will allow healthcare providers to begin tuberculosis treatment far sooner, sharply reducing the risk that infected individuals will spread the disease to others.

It also will lead to more effective treatment of individual patients by telling clinicians whether disease-causing bacteria are drug-resistant.

Dr. Alland began work on the screening test, which is called Xpert MTB/RIF (Mycobacterium tuberculosis/resistance to rifampin), more than a decade ago.

The test took four years to develop, followed by the process of attracting funding to refine and manufacture it and then conducting the clinical trials that established its effectiveness. (ANI)

Dec 10
'Need global collaborative research to fight cancer'
There is an urgent need for collaborative research on a global level to fight cancer, said Dr George Komatsoulis, deputy director, Centre for Biomedical Informatics and Information Technology (CBIIT), National Cancer Institute (NCI), USA.

Komatsoulis was speaking as the chief guest at the second meet on the Cancer Biomedical Informatics Grid (caBIG) organised by the Centre for Development of Advanced Computing (C-DAC) here on Thursday.

"Clinical research is a vital tool to shaping the system and the caBIG seeks to create a worldwide web of cancer researchers with open principles of access, development, source and federation. The focus is on providing access to cancer data to authorised people irrespective of location so that researchers can accelerate their research or explore new areas, towards the treatment of cancer."

Komatsoulis said it is crucial to work towards improving bio-medical care and research.

Rajan T Joseph, director general, C-DAC, Dr Hemant Darbari, executive director, C-DAC, Dr Pradeep K Sinha, senior director-HPC, C-DAC were also present.

The cancer Biomedical Informatics Grid is an information network enabling all constituencies in the cancer community. It is sponsored by the National Cancer Institute (NCI), USA, and its activities are supervised by the National Cancer Institute Center for Bioinformatics (NCICB). He also spoke about the Indo-US grid for collaborations that will have their tools and technologies which will be used by researchers. The two-day meet will work towards promoting the exchange of information and knowledge on the healthcare sector.

Dr Hemant Darbari said, "Cancer as an area where we can put our expertise to good use, and we needed a common intent where C-DAC's capabilities could be effectively used.

Dec 10
Too much hygiene affects immune system
Children and teenagers who are overexposed to antibacterial soaps that contain the chemical triclosan may be at risk for hay fever and other allergies, a finding that suggests that being too clean can actually make people sick. The study also found that exposure to higher levels of the chemical bisphenol A (BPA) may weaken an adult's immune system.

Triclosan is an antimicrobial agent widely used in products such as antibacterial soaps, toothpaste, medical devices and diaper bags. BPA, which is used to make many types of plastics and other consumer products, is believed to affect human hormones.

Researchers analysed data from the 2003-2006 National Health and Nutrition Examination Survey in America. They compared levels of triclosan and BPA in the urine with cytomegalovirus (CMV) antibody levels and diagnosis of allergies or hay fever in adults and children over age 6 years.

It was found that people over 18 years with higher levels of BPA exposure had higher CMV antibody levels, which suggests their cell-mediated immune system may not be functioning properly. The researchers also found that children and teenagers with higher levels of triclosan were more likely to have been diagnosed with hay fever and other allergies.

The triclosan findings in the younger age groups may support the hygiene hypothesis, which maintains living in very clean and hygienic environments may impact our exposure to microorganisms that are beneficial for proper development of the immune system.

Dec 09
Print Email Share New test to revolutionise TB diagnosis
The World Health Organisation (WHO) has endorsed what it says is a revolutionary new way of diagnosing tuberculosis.

The test can be done on the spot in 100 minutes compared to the weeks and months it has traditionally taken in a highly equipped and secure laboratory.

It was co-developed by scientists in the US, Geneva and a drug manufacturer and is expected to help save many of the 5,000 people who die every day worldwide from the treatable lung illness.

WHO head of TB diagnostics Dr Karin Weyer says all countries are being urged to roll out the technology, including Australia.

"The new test is revolutionary in several ways," she said.

"Number one, it diagnoses TB and drug-resistant TB simultaneously in an assay that takes only 100 minutes in a machine that looks a little bit like a coffee machine where one puts the sputum in," she said.

"You switch the machine on and everything is done inside the machine. A hundred minutes later the computer screen provides a result and also tells you if that TB is drug-resistant or not."

Dr Weyer says in some countries up to 30 per cent of tuberculosis cases can be drug-resistant.

She says the new test will revolutionise how tuberculosis is diagnosed around the world.

"We expect to see at least a three-fold increase in the number of patients with multi-drug-resistant TB detected with this test," she said.

"And in HIV settings we've seen a doubling of cases being detected with this test.

"As a result of that, we also hope to see a significant decline in deaths from tuberculosis, especially in HIV-positive patients where often by the time the diagnosis gets back to the patient, the patient has already died."

She says low and middle-income countries will receive a 75 per cent reduction in the cost of the test.

"As demand and volumes rise there will be more significant reductions over the next year to two years to a point where the test will not be more than $10," she said.

"That is 50 per cent of what we are paying today for doing some of the older tests."

While there could be a rapid increase in the number of people diagnosed with tuberculosis with the new technology, Dr Weyer says there will also need to be extra treatment available.

But she says the treatment, especially for the drug-resistant strand of the disease, is "hugely expensive".

"So countries do have to rely at this point on donor funding to help them scale up the treatment also," she said.

She says in countries like Australia, where there are only about 1,000 new cases every year, the new test is still recommended.

"It's completely safe. It can be done in a doctor's consulting room and patients would benefit from having a diagnosis immediately," she said.

Dec 08
Scientists develop drug that can stop post-traumatic stress disorder before it starts
Scientists have discovered a way to stop post-traumatic stress syndrome in its tracks - by injecting a calming drug into the brain.

Around 30 per cent of people who experience a traumatic event will develop the severe anxiety disorder, which overwhelms a person's ability to cope.

Symptoms can include vivid flashbacks, emotional numbness and nightmares.

While two-thirds recover within a few months some are dogged by the condition for years.

Now researchers from Northwestern University have found the molecular cause of the debilitating syndrome and a way to treat it.

They found that after a traumatic event the brain can become over-stimulated causing an ongoing, frenzied interaction between two brain proteins long after they should have disengaged.

'It's like they keep dancing even after the music stops,' said lead investigator Jelena Radulovic.

However, they found injecting two newly developed research drugs MPEP and MTEP, into the brain's hippocampus ended 'the dance.'

'We were able to stop the development of exaggerated fear with a simple, single drug treatment and found the window of time we have to intervene,' Assistant Professor Radulovic said.

However, the effect only worked if the drug was administered within five hours of the event.

Past studies have tried to treat the extreme fear responses, after they have already developed, she noted.

The study, conducted with mice, was published in the journal Biological Psychiatry.

An exaggerated fear disorder can be triggered by combat, an earthquake, a tsunami, rape or any traumatic psychological or physical event.

'People with this syndrome feel danger in everything that surrounds them,' Ms Radulovic said.

'They are permanently alert and aroused because they expect something bad to happen. They have insomnia; their social and family bonds are severed or strained. They avoid many situations because they are afraid something bad will happen.

'Even the smallest cues that resemble the traumatic event will trigger a full-blown panic attack.'

In a panic attack, a person's heart rate shoots up, they may gasp for breath, sweat profusely and have a feeling of impending death.

Many people bounce back to normal functioning after stressful or dangerous situations have passed. Others may develop an acute stress disorder that goes away after a short period of time. But some go on to develop post-traumatic stress syndrome, which can appear after a time lag.

Dec 08
Laser surgery corrects rare disorder in twin foetus
When Surat-based Tabassum Ashraf, 27, started experiencing a rapid increase in her heart beat and pulse rate followed by premature labour pains, she knew all was not well with her pregnancy. The gynaecologist told Tabassum, then 20-week pregnant with twins, that the foetus were suffering from a rare disorder, Twin-Twin Transfusion Syndrome, that usually leads to a miscarriage. A team of doctors at Jaslok Hospital led by foetal medicine specialist Dr Chander Lulla, performed a laser surgery using a foetoscope to cure the condition. This is the first time that such a surgery has been performed in India.

"There are very few centres in the world that conduct the surgery as it requires expertise and expensive equipment," Lulla said on Tuesday. The Twin-Twin Transfusion Syndrome affects 10% of pregnancies with identical twins, where both foetus share the same placenta that connects them to the uterine wall for nutrient intake.

In this syndrome, an unequal sharing of blood takes place between the twins leading to one, called the donor twin, becoming small and anaemic with no amniotic fluid around it. The other twin, known as the recipient twin, receives excess blood and faces the risk of cardiac failure. Increased fluid around the recipient twin can also lead to premature labour and due to the lack of fluid around the donor twin, it does not develop a bladder.

Jaslok Hospital doctors inserted a laser beam in the womb using a foetoscope to burn the connection between the two foetus to stop the sharing of blood. The other cure for the condition is to extract the excess amniotic fluid around the recipient foetus. However, that does not help the donor foetus and may cause its death.

"The doctor told me there was one-third chance that the surgery would be successful and an equal chance that I could lose one or both my babies," said Yunus Ashraf, an insurance professional.

Doctors felt that delaying the surgery could have caused severe complications. On November 23, after Dr Lulla was able to source the foetoscopes from different parts of the country, Tabassum was taken to the operating theatre. Tabassum was under spinal anesthesia and could see the procedure being carried out on a television screen.

The twins are doing well and are constantly being monitored. "Two days after the surgery, amniotic fluid started collecting around the donor baby and its bladder started developing," said Dr Lulla.

Dec 07
Yawning not contagious in babies--study
If someone near you yawns, chances are that in a few seconds you will follow suit.

Babies, show no signs of succumbing to this well-known phenomenon called contagious yawning which is catching among people, dogs, and also chimpanzees, claims a new study.

According to researchers, yawning in toddlers and babies is spontaneous, and they almost never yawn back until the age of five when contagious yawning starts triggering a chain reaction.

Given that contagious yawning may be a sign of empathy, researchers theorize that empathy and the mimicry that may underlie it develops slowly over the first few years of life.

Lead researchers, Dr Jim Anderson, a reader in psychology
at the University of Stirling stated, "The exact reason why we yawn isn't really understood very well at all, but there is no doubt that as adults it is highly contagious.

"People who score highly for empathy are significantly more likely to show contagious yawning. What we know from other research is that one part of the brain that continues to develop through out childhood is the frontal cortex and that the frontal lobes play a role in social decision making and the ability to empathise.

"That would tie in with the gradual development of contagious yawning during childhood."

A two-part study conducted
Researchers conducted a study to trace the development of contagious yawning among kids at various stages of social development.

Mothers were asked to record when and how often their kids yawned in the first part of the study.

It was noted that babies between the age group of six and 34 months were inclined to yawn the most on waking in the morning or after naps.

However, they yawned on average about two times daily which is no where near the seven to nine times per day that an adult yawns.

Also, none exhibited signs of contagious yawning.

Findings of the second study
In the second part of the study, the investigators examined the yawning behavior of 22 babies whose average age was two years.

The kids were shown video clippings of babies, animals, adults and even their mother's yawning.

It was observed that videotaped footage induced yawning in only three of the 22 infants.

The authors stated, "The largely negative video results confirm that infants and preschoolers are much less susceptible to psychological influences on yawning when compared with older children and adults."

Contagious yawning develops after five years
Previous study has established that contagious yawning is a behavior that starts developing after the age of five.

By the time kids reach the age of 12, this deeply rooted behavior acquires the same levels as those found in adults.

Anderson stated, "Young children may also do less contagious yawning simply because they don't have the same pressures or social inhibitions as adults: They yawn where they like and when they like."

The study appears in the journal 'Biology Letters.'

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