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Jan 04
Indian-made vaccine for swine flu
MADURAI: Indigenous vaccine for swine flu will be available by March along with testing kits at just 25 per cent of the cost of its foreign counterpart, according to Dr V M Katoch, secretary, Department of Health Research and Director General of Indian Council of Medical Research.

He said that five Indian companies were working on it and had made good progress.

Opining that H1N1 would be wiped out in the country within a year as humans would develop immunity in due course, he said a national- level network among universities would be created to assist National Centre for Disease Control (NCDC) and the National Institute of Virology (NIV) in tackling such epidemics in future.

When asked about the progress on genetically modified mosquito that are resistant to malaria, Katoch said a policy decision was yet to be taken on the issue, as it requires detailed assessment of its likely impact.

A better way is to keep surroundings clean and avoid mosquito breeding, he said.

Jan 04
How medicines affect pregnancy
For the first time a study has been launched that will gauge how exactly common medications affect pregnancy.

The FDA and a consortium of HMOs have launched a huge set of studies to find out how medications affect women during pregnancy.

"These data will guide regulatory policy and influence medical practice," Webmd quoted the FDA Commissioner Dr. Margaret Hamburg, as saying in a news release.

While many women do take some kind of medicine during pregnancy, but very few drugs are tested in pregnant women.

But now, the Medication Exposure in Pregnancy Risk Evaluation Program (MEPREP) has been launched.

The program is a collaboration between the FDA, Kaiser Permanente, Vanderbilt University (using Tennessee Medicaid data), and a consortium of HMOs called the HMO Research Network Center for Education and Research in Therapeutics (managed by Harvard University).

The study will analyze health care data on about 1 million U.S. births from 2001 to 2007.

The idea is to gather information on all medications prescribed for pregnant women and to look for health effects and birth outcomes.

"Results of these studies will provide valuable information for patients and physicians when making decisions about medication during pregnancy," said Dr. Gerald Dal Pan.

Until the data become available, women and their doctors will have to make their own decisions on whether a drug provides enough of a benefit to pregnant women to override concerns about possible risk.

Jan 02
Rapid H1N1 testing method developed
Scientists in the US have developed a rapid and automated swine flu testing method that will enable quick and effective diagnosis decisions.

Researchers from the Wisconsin Medical College and Children's Hospital have developed a rapid and automated system to differentiate strains of influenza, Journal of Molecular Diagnostics reported.

The method -- Real-Time Reverse Transcriptase Polymerase Chain Reaction (real-time RT-PCR) is a sensitive and specific method for identifying flu substrains; however, technician and assay time are significantly longer than less accurate rapid influenza diagnostic tests
.

The team led by Dr Kelly J Henrickson of the Medical College of Wisconsin said, the test which will detect influenza A, influenza B and respiratory syncytial virus (RSV) in no time, is needed in order to make quick and effective public health decisions in time of pandemic infection.

The test can successfully detect human H1N1, H3N2, and swine-origin H1N1 viruses as well as distinguish these from influenza B and RSV infections, Henrickson said.

He said, these assays could test large numbers of samples over a very short time, allowing for a significant decrease in both technician and assay time.

Jan 01
Stem cell therapy hold hope for blindness
Advances in stem cell treatment may make it possible to cure blindness. This was demonstrated when eight partially blind patients, who participated in the trial of a new treatment to restore vision at the North East England Stem Cell Institute (NESCI), Newcastle, reported radically improved vision among other benefits.

Among the patients was 38-year-old Russell Turnbull from Consett, Durham. He lost most of the vision in his right eye in 1994, when he had ammonia sprayed on his face even as he attempted to intervene in a quarrel on a bus. His cornea was burnt as a result of this leading to clouded sight, sensitivity to light and pain while blinking.

The chemical burn damaged Turnbull's limbal stem cells - a collection of special cells in the eye that are important to maintain the smooth, transparent outer surface of the cornea. As a result he suffered a limbal stem cell deficiency (LSCD), a condition that causes the retina to become cloudy and rough, causing pain and sensitivity to light.

Doctors used limbal stem cells from Turnbull's functioning eye to grow more of these in a laboratory. These cells were then spread over a human amniotic membrane, which is the tissue that generally supports fetuses while they are in the womb. The stem cell grafts were then used to replace the damaged corneal tissue, enabling Turnbull to get back his sight.

Turnbull who, apart from blindness, also complained of pain and constant watering, has now almost recovered normal vision with no pain, just about a year and a half after the treatment. He has started working again and has resumed jet skiing and riding, hobbies which he had had to give up after the accident.

The trial of the treatment procedure was carried out by Dr Francisco Figueiredo and Dr Sajjad Ahmad, of the Royal Victoria Infirmary. All eight patients, with blindness in one eye due to LSCD, reported improvement about 19 months after the treatment.

Currently the treatment procedure is only useful for patients with one undamaged eye, from which stem cells can be removed and grown, explained Dr Ahmad. However in the future it may even be possible to use cells from other parts of the body to grow limbal stem cells to treat patients with bilateral blindness, he hoped.

About eight million people worldwide are estimated to suffer from blindness induced by corneal cloudiness each year. A report on the new treatment has been published in the journal Stem Cells.

Jan 01
Vitamin E Overuse May Do More Harm Than Good
In a recent study it has been observed that, Vitamin E overuse may do more harm than good. This finding has been disclosed by the researchers at the Tel Aviv University (TAU) Sackler School of Medicine.

According to the researchers, such indiscriminate use of antioxidants may also affect our internal organs including heart.

"There were so many conflicting reports about vitamin E and its effect on various diseases, particularly heart disease, that we wanted to set the record straight," says Dov Lichtenberg, professor at the Tel Aviv University (TAU) Sackler School of Medicine.

"Our new study shows that some people may be harmed by the treatment, whereas others may benefit from it. Now we're trying to identify groups of people that are most likely to benefit from the effects of Vitamin E," adds study co-author Ilya Pinchuk.

Analysing various results, they concluded that the persons who did not take a vitamin E supplement enjoyed more quality-adjusted-life-years (QALY) than the other. Quality-adjusted-life-years (QALY) is a standard parameter used in medicine to assess the effect of medical interventions on our body.

These findings have been published in the cardiology journal ATVB.

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