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Jan 11
Delay pregnancy after obesity surgery, women warned
Women who have had weight loss surgery should wait at least a year before trying for a baby, experts have warned.

Having a baby after surgery is safer and associated with fewer complications than becoming pregnant when morbidly obese, say doctors.

But patients should still be treated as high-risk and be "strongly advised" not to get pregnant for 12 to 18 months afterwards, a review suggests.

Obesity among women of childbearing age is expected to rise to 28% by 2015.

National guidelines recommend weight loss surgery - most commonly done through a gastric band or gastric bypass - as an option for anyone with a body mass index of more than 40kg/sq m.

The review of the latest evidence, published in The Obstetrician and Gynaecologist journal, says that it will become more and more common for doctors to be asked for advice about the safety of becoming pregnant after bariatric surgery.

Yet there is a lack of guidance on how to manage such patients.
Surgical complications

Researchers found that most women who get pregnant after bariatric surgery would have no complications, with one study suggesting 79% would have a straightforward pregnancy.

But there can be surgical complications with the potential for a gastric band to slip or move during pregnancy, leading to severe vomiting.

One study found that band leakage was reported in 24% of pregnancies.

Women who become pregnant after weight loss surgery should be managed by a team of experts that includes an obstetrician, surgeon, fertility specialist and nutritionist, the review recommends.

The researchers also pointed out that the female patients should receive advice and information before they got pregnant, on contraception, nutrition and weight gain, and vitamin supplements.

Advising women who have had weight loss surgery to wait at least 12 months before trying to conceive, they pointed to research showing an increased risk of miscarriage.

One study found that 31% of pregnancies occurring within 18 months of having weight loss surgery ended in spontaneous miscarriage compared with 18% in women who got pregnant after 18 months.

Rahat Khan, consultant obstetrician and gynaecologist at Princess Alexandra Hospital NHS Trust in Harlow, Essex, and co-author of the review, said this issue was affecting an increasing number of women of childbearing age.

"In light of current evidence available, pregnancy after bariatric surgery is safer, with fewer complications, than pregnancy in morbidly obese women," he said.

But he added this group of women should still be considered to be high risk.

Daghni Rajasingam, of the Royal College of Obstetricians and Gynaecologists, said obesity was associated with a number of serious risks in pregnancy, and women should be supported to lose weight before conception.

"It is important that women are aware of the increased risk of maternal and fetal complications associated with obesity, and they should be advised about the possible strategies to minimise them prior to conception."

Jan 11
Lung infection identified using 'breath-print'
Identifying the "smell" of different types of lung bacteria could lead to a simple breath test to diagnose infections, a study on mice, in the Journal of Breath Research, suggests.

Breath analysis could reduce lung infection diagnosis times from weeks to minutes, the Vermont researchers said.

Scientists have already researched breath tests to diagnose asthma and cancer.

An expert said breath analysis was "an important and emerging field".

Diagnosing bacterial infections traditionally means collecting a sample that is used to grow bacteria in the lab. This bacteria is then tested to classify it and see how it responds to antibiotics, which can take time.

Doctors see breath analysis, in contrast, as a fast and non-invasive method of diagnosing diseases.

For the study, researchers from the University of Vermont analysed volatile organic compounds (VOCs) given off in exhaled breath by different bacteria as well as different strains of the same bacterium.

They infected mice with two bacteria that are both common in lung infections - Pseudomonas aeruginosa and Staphylococcus aureus - and sampled their breath after 24 hours.
'Useful tool'

The compounds in their breath were analysed using a technique called secondary electrospray ionisation mass spectrometry (SESI-MS), which is capable of detecting extremely small elements of the chemicals present in their breath.

The researchers said they found a "statistically significant" difference between the breath profiles of the mice infected with the bacteria and the mice that were uninfected.

They also said they were able to differentiate between two species of bacteria and two different strains of the same P. aeruginosa bacterium.

But Jane Hill, co-author of the study, from the University of Vermont College of Medicine, said there were still some challenges to overcome with "breath-prints".

"We are now collaborating with colleagues to sample patients in order to demonstrate the strengths, as well as limitations, of breath analysis more comprehensively," she said.

Richard Hubbard, professor of respiratory epidemiology at Nottingham City Hospital and a spokesman for the British Lung Foundation, said breath analysis was already being used to diagnose children with asthma.

"Breath analysis is an emerging field and is likely to take off across the board. It could be a very useful tool for children with cystic fibrosis, for example, as a guide on how to treat them," he said.

Jan 10
Sickle-shaped blood cells 'may kill cancer cells in mice'
Misshapen red blood cells could be used as a tool to kill cancer cells in mice, research in the journal Plos One shows.

Sickle-shaped cells can stick together in blood vessels surrounding tumours in mice and block blood flowing to the cancer, researchers says.

The irregularly shaped cells can also deposit toxic residues on the tumour, leading to cancer cell death.

This research focuses on oxygen-poor areas in tumours which have proven difficult to treat in humans.

The US researchers from Duke University and Jenomic, a private research company, gave a fluorescent sickle-cell solution to mice with cancer and watched what happened inside their systems.

Within five minutes the misshapen cells began to stick like 'Velcro' to blood vessels near the oxygen-starved areas of the tumour, Prof Mark Dewhirst co-author of the study, from Duke University, said.
Exclusive target

At 30 minutes the cells formed clots and began to block small blood vessels which fed the tumour.

And the sickle-shaped cells exclusively targeted the oxygen-low areas of tumour, which can become increasingly aggressive forms of cancer in humans.

"We found that sickle cells show a highly unique natural attraction to oxygen-deprived tumours.

"Once clustered within the tumour, the sickle cells deposit a toxic residue... causing tumour cell death," Dr David Terman, a co-author of the study and head of molecular genetics at Jenomic said.

Sickle-shaped cells are normally present in humans who inherit a genetic condition known as sickle cell anaemia.

Unlike normal disc-shaped blood cells, these crescent-moon shaped cells do not flow smoothly through blood vessels and can clump together to block blood supply.

This can result in a sickle crisis - often causing severe pain in the affected region and sometimes a complete and dangerous stop to blood flow in the area.

"The very qualities that make sickle cells a danger to people with the inherited genetic disorder can be turned against tumours to fight cancer," said Dr Terman.

"This is an intriguing new tactic for destroying tumours that are resistant to standard treatments, but the research was carried out in mice so the next challenge will be to show whether this approach is safe and effective in people with cancer," said Dr Emma Smith of Cancer Research UK.

The researchers say their approach could be directed at breast cancers, prostate cancers and many other tumours that develop resistance to current therapies, once more animal studies and human trials have been carried out.

Jan 10
Science puts wrinkled fingers to the test
Science may be getting closer to explaining those prune-like fingers and toes we all get when we sit in a hot bath too long.

UK researchers from Newcastle University have confirmed wet objects are easier to handle with wrinkled fingers than with dry, smooth ones.

They suggest our ancestors may have evolved the creases as they moved and foraged for food in wet conditions.

Their experiments are reported in the Royal Society journal Biology Letters.

These involved asking volunteers to pick up marbles immersed in a bucket of water with one hand and then passing them through a small slot to be deposited by the other hand in a second container.

Volunteers with wrinkled fingers routinely completed the task faster than their smooth-skinned counterparts.

The team found there was no advantage from ridged fingers when moving dry objects. This suggests that the wrinkles serve the specific function of improving our grip on objects under water or when dealing with wet surfaces in general.

For a long time, it was assumed that the wrinkles were simply the result of the skin swelling in water, but recent investigations have actually shown the furrows to be caused by the blood vessels constricting in reaction to the water, which in turn is a response controlled by the body's sympathetic nervous system.

That an active system of regulation is at work led scientists into thinking there must be some deeper evolutionary justification for the ridges.

"If wrinkled fingers were just the result of the skin swelling as it took up water, it could still have a function but it wouldn't need to," said Dr Tom Smulders, from Newcastle's Centre for Behaviour and Evolution.

"Whereas, if the nervous system is actively controlling this behaviour under some circumstances and not others, it seems less of a leap to assume there must be a function for it, and that evolution has selected it. And evolution wouldn't have selected it unless it conferred some sort of advantage," he told BBC News.

US-based researchers were the first to propose that the wrinkles might act like the tread on tyres, and even demonstrated how the patterns in the skin resembled those of run-off channels seen on the sides of hills.
Wet trees

What the Newcastle team has now done is confirm that prune-like fingers are indeed better at gripping wet objects.

"We have tested the first prediction of the hypothesis - that handling should be improved," Dr Smulders said.

"What we haven't done yet is show why - to see if the wrinkles remove the water, or whether it's some other feature of those wrinkles such as a change in their stickiness or plasticity, or something else. The next thing will be to measure precisely what's happening at that interface between the objects and the fingers."

Our ancestors might not have played with wet marbles, but having better gripping fingers and feet would certainly have been advantageous as they clambered about and foraged for food along lake-shores and by rivers.

It would be interesting to see, observed Dr Smulders, just how many other animals displayed this trait - in particular, in primates.

"If it's in many, many primates then my guess is that the original function might have been locomotion through wet vegetation or wet trees. Whereas, if it's just in humans that we see this then we might consider something much more specific, such as foraging in and along rivers and the like."

Jan 09
Beta-blockers 'may lower dementia risk'
Taking beta-blocker drugs may cut the risk of dementia, a trial in 774 men suggests.

The medication is used to treat high blood pressure, a known risk factor for dementia.

In the study, which will be presented at the American Academy of Neurology's annual meeting in March, men on beta-blockers were less likely to have brain changes suggestive of dementia.

Experts say it is too early to recommend beta-blockers for dementia.

The findings are preliminary and larger studies in men and women from different ethnicities are needed to see what benefit beta-blockers might offer.

People with high blood pressure are advised to see their doctor and get their condition under control to prevent associated complications like heart disease, stroke and vascular dementia.
Brain blood flow

Having high blood pressure may damage the small vessels that supply the brain with blood.

Blood carries essential oxygen and nourishment to the brain and without it, brain cells can die.

Vascular dementia is the second most common cause of dementia after Alzheimer's disease and can occur if blood flow to the brain is reduced.

Other research in a much larger sample of men - 800,000 in all - suggests another type of blood pressure drug known as an angiotensin receptor blocker (ARB) may cut dementia risk, including Alzheimer's disease, by as much as 50%.

The latest work in 774 Japanese-American men found that all types of blood pressure medication were better than no treatment in terms of signs of dementia in the brain - brain shrinkage and tiny areas of brain tissue damage caused by poor blood supply - noted at autopsy after death.

However, men who had received beta-blockers as their only blood pressure medication had fewer abnormalities in their brains than those who had not been treated for their hypertension, or who had received other blood pressure medications, the University of Hawaii team found.

Men on beta-blockers and other medications also had fewer brain abnormalities, but not as big a reduction as that seen in the men on beta-blockers alone.

In the study, 610 of the men had high blood pressure or were being treated for high blood pressure.

Study author Dr Lon White said: "With the number of people with Alzheimer's disease expected to grow significantly as our population ages, it is increasingly important to identify factors that could delay or prevent the disease.

"These results are exciting, especially since beta-blockers are a common treatment for high blood pressure."

Dr Simon Ridley, head of research at Alzheimer's Research UK, said: "Hypertension is a known risk factor for Alzheimer's and other causes of dementia, and keeping high blood pressure in check could be important for preventing these diseases.

"This study suggests a link between the use of beta-blockers and fewer signs of dementia, but as the results of this study have yet to be published in full, it's not clear what caused this link. It's important to note that this study only looked at Japanese-American men, and these results may not be applicable to the wider population.

He said a better understanding of the links between high blood pressure and dementia could be crucial for developing new treatments or approaches to prevention.

"With 820,000 people affected by dementia in the UK, and that number increasing, we urgently need to find ways to prevent the diseases that cause it - that requires a massive investment in research," Dr Ridley added.

Jan 09
Totally blind mice get sight back
Totally blind mice have had their sight restored by injections of light-sensing cells into the eye, UK researchers report.

The team in Oxford said their studies closely resemble the treatments that would be needed in people with degenerative eye disease.

Similar results have already been achieved with night-blind mice.

Experts said the field was advancing rapidly, but there were still questions about the quality of vision restored.

Patients with retinitis pigmentosa gradually lose light-sensing cells from the retina and can become blind.

The research team, at the University of Oxford, used mice with a complete lack of light-sensing photoreceptor cells in their retinas. The mice were unable to tell the difference between light and dark.
Reconstruction

They injected "precursor" cells which will develop into the building blocks of a retina once inside the eye. Two weeks after the injections a retina had formed, according to the findings presented in the Proceedings of the National Academy of Sciences journal.

Prof Robert MacLaren said: "We have recreated the whole structure, basically it's the first proof that you can take a completely blind mouse, put the cells in and reconstruct the entire light-sensitive layer."

Previous studies have achieved similar results with mice that had a partially degenerated retina. Prof MacLaren said this was like "restoring a whole computer screen rather than repairing individual pixels".

The mice were tested to see if they fled being in a bright area, if their pupils constricted in response to light and had their brain scanned to see if visual information was being processed by the mind.
Vision

Prof Pete Coffee, from the Institute of Ophthalmology at University College London, said the findings were important as they looked at the "most clinically relevant and severe case" of blindness.

"This is probably what you would need to do to restore sight in a patient that has lost their vision," he said.

However, he said this and similar studies needed to show how good the recovered vision was as brain scans and tests of light sensitivity were not enough.

He said: "Can they tell the difference between a nasty animal and something to eat?"

Prof Robin Ali published research in the journal Nature showing that transplanting cells could restore vision in night-blind mice and then showed the same technique worked in a range of mice with degenerated retinas.

He said: "These papers demonstrate that it is possible to transplant photoreceptor cells into a range of mice even with a severe level of degeneration.

"I think it's great that another group is showing the utility of photoreceptor transplantation."

Researchers are already trialling human embryonic stem cells, at Moorfields Eye Hospital, in patients with Stargardt's disease. Early results suggest the technique is safe but reliable results will take several years.

Retinal chips or bionic eyes are also being trialled in patients with retinitis pigmentosa.

Jan 08
Stomach bugs linked to wetter conditions, storms
Rain and bigger storms could be the cause of more stomach bugs in certain countries, according to new research.

Torrential rain leads drains to overflow, releasing germ and virus riddled water into waterways and if this water is swallowed while engaging in watersports for example, it can make people sick.

According to research, it is more likely to be viruses that cause people to be ill rather than the germs.

The research was carried out as part of a project called Viroclime which aims to improve tools for tracking harmful viruses from human sewage in European waters.

It looked at viruses from five European sites including Spain, Hungary, Sweden, and Greece and one site in Brazil.

There are two types of virus which could act as a signal to more serious water-based diseases - one belongs to the winter vomiting bug family, the other to noroviruses.

"If we had better data, which EU project Viroclime can gather, and we analyse the data using a health risk-based approach, we could get better estimated disease burdens from recreational water exposures," Mark Sobsey, a virologist from the University of North Carolina, said.

However, he added that testing water for viruses is still difficult and costly.

Scientists believe that being able to monitor viruses in water could help them predict the effects of climate change and to develop new health protection measures to suit such change.

It could also help predict a rise in the number of stomach illnesses by exploiting the link to rainfall.

Jan 08
Sleep apnea may offer unusual protection for heart attack patients
People who suffer from breathing disorders such as sleep apnea are usually at higher risk for cardiovascular disease.

But findings of a new study carried out by scientists from Technion-Israel Institute of Technology have shown that some heart attack patients can actually benefit from mild to moderate sleep-disordered breathing.

Apnea and other types of sleep-disordered breathing can boost the numbers and functions of rare cells that help to repair and build new blood vessels, according to the Technion``s Dr. Lena Lavie and her colleagues.

They say the findings could help predict which patients are at a greater health risk after a heart attack, and may even suggest ways to rebuild damaged heart tissue.

The scientists`` study could help resolve a puzzling medical issue. If sleep disordered breathing is associated with cardiovascular disease, why is it that people who suffer from breathing disorders in sleep seem to do as well as healthy sleepers after a heart attack?

Lavie, along with researchers Dr. Slava Berger, Prof. Doron Aronson and Prof. Peretz Lavie, looked for clues to this puzzle in 40 male patients - a mix of healthy sleepers and those with sleep disordered breathing, who had had a heart attack just a few days earlier.

Blood samples drawn from these patients revealed that the sleep disordered breathing patients had markedly higher levels of endothelial progenitor cells (EPCs), which give rise to new blood vessels and repair the injured heart, than the healthy sleepers. They also had higher levels of other growth-promoting proteins and immune cells that stimulate blood vessel production.

The Technion researchers were able to trigger a similar increase in vessel-building activity in vascular cells taken from a second set of twelve healthy men and women, by withholding oxygen from the cells for short periods.
"Indeed, our results point at the possibility that inducing mild-moderate intermittent hypoxia may have beneficial effects," Lena Lavie said.

The study has been published in the American Journal of Respiratory and Critical Care Medicine.

Jan 07
Break from booze 'boosts health and reverses damage'
Taking a break from drinking alcohol can improve your health, experts say.

According to experts, even if you avoid overindulging around the holidays starting off the New Year with a short break from booze can transform your body and mind turn out that much of the damage that alcohol does can be reversed.



Minus any moisture-sapping alcohol, your skin will look and feel more hydrated, any ruddiness in your cheeks and nose will fade, non-chronic dandruff, eczema, or rosacea should lessen or disappear.

Alcohol may make you sleepy but it also disrupts the quality of your sleep, which means you're now getting the sounder shut-eye that leads to increased concentration and energy levels, ABC News reported.

Your liver loves you because it no longer has to work double time to neutralize boozy toxins and can now home in on other stuff like helping you recover faster from scrapes or bruising.

If you suffer wonky digestion, and especially acid reflux, your symptoms should drastically improve.

Since alcohol is by its nature a depressant, it can drag down the outlook of drinkers, which means you should now start noticing increased mental clarity and much better moods.

Lots of women booze to relax, but a lot of alcohol actually makes the heart work much harder over time, and without that extra burden, your pulse rate is lower and you're better able to exercise.

Most alcohol is loaded with sugar and empty calories, which often show up as belly fat.

Additionally, for women trying to get pregnant, you now have a better chance of conceiving.

Jan 07
Carrot can cure several ailments
Carrot can offer prevention against different ailments, say health experts.

The vegetable-cum-fruit contains rich vitamin and mineral contents, besides other valuable nutrients.

Considering the effectiveness of carrot, doctors and health experts have declared it "apple" for the people having meager resources, the News reported.

Dr. Mian Iftikhar, a Medical Specialist, said that carrot especially its juice, is better for stomach and gastrointestinal health, which also solves a variety of digestive problems.

He said carrot is useful in different cases like stomach disorder, peptic ulcers, gastritis, crohn's disease (chronic inflammatory disease affecting the whole of the alimentary tract), diarrhoea, celiac disease (defective digestion found in children).

Carrot juice, combined with spinach and a little lemon juice, is very effective in the treatment of constipation, he added.

The juice cleanses the bowels, he said and added that this effect could not be expected soon after taking the juice but within two months, the bowel starts emptying regularly.

Family Physician Dr. Syed Hasnain Ali Johar, added that appropriate use of carrot is helpful in fighting obesity, poisoning of the blood, gum disease, insomnia, inflamed kidney, liver, gallbladder, Alzheimer's disease, colitis, ulcer and painful urination.

He said it is an excellent source of pro-vitamin A, vitamins C, D, E, K, B1 and B6, adding that carrot is also rich with biotin, potassium, calcium, magnesium, phosphorus, organic sodium and some trace minerals.

The doctor said carrot could enhance the quality of mother's milk, improving the appearance of skin, hair and nails.
He noted the carrot soup has been found as an effective natural remedy for diarrhoea, which supplies fluid to combat dehydration, replenishes sodium, potassium, phosphorus, calcium, sulfur and magnesium.

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