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Aug 09
Black henna can be `deadly for health`
A senior official of Abu Dhabi Municipality has warned that black henna contains toxic chemicals which can cause burns, allergic reactions and can be fatal if used extensively.

Khaleefa Al Romaithi, public health administration director at the Municipality told XPRESS that through their awareness campaigns, they are trying to spread the message that `traditionally there is nothing called black henna,` the Gulf News reported.

He said dangerous chemicals and even petrol, car oil and hair dye are mixed with henna to give a black tint to the natural reddish-brown colour of henna.

Al Romaithi warned that certain chemicals used in black henna can drastically reduce the oxygen levels in the body.

However, despite the ban by both Abu Dhabi Municipality and Dubai Municipality, women say black henna is still being used at private parties and desert safaris.

Aug 08
Weight loss surgery reverses fatty liver disease symptoms
Researchers have found that weight loss surgery can reverse the symptoms of fatty liver disease.

Earlier research has found that the surgery not only benefits obese people to shed their extra pounds, it also causes early remission of type 2 diabetes.

The findings are derived from research on liver samples in normal and obese patients-some with fatty liver disease and some without fatty liver disease.

The results provide another example of the DNA-altering effects of weight loss surgery.

Nonalcoholic fatty liver disease (NAFLD)-which includes a spectrum of liver disorders in people with obesity and type 2 diabetes-is the most common chronic liver disorder in industrialized countries.

NAFLD has emerged as one of the dominant types of liver disease worldwide and affects one in three Americans.

In an experimental tour de force, researchers analyzed liver samples from 27 obese individuals with different stages of NAFLD, 18 healthy obese individuals without liver disease, and 18 normal-weight individuals without liver disease. Methylation-a chemical modification on DNA that regulates gene expression-was altered on various genes in patients with NAFLD.

The expression levels of nine of these genes-which code for key enzymes involved in metabolism and insulin signaling-were also different from those seen in healthy individuals.

Furthermore, binding sites for proteins that affect gene expression were enriched in the liver disease patients` genes.

Dr. Joseph Hampe and his colleagues at University Hospital Dresden, Germany, also found that when they compared patients` liver biopsies before and after weight loss surgery, the NAFLD-associated methylation changes were partially reversible.

The findings demonstrate that weight loss surgery changes the chemical properties of DNA, thereby affecting gene expression.

The findings are published online in the Cell Press journal Cell Metabolism.

Aug 08
Anorexic girls also have autistic traits, study finds
Scientists studying girls with the eating disorder anorexia have found they show a mild echo of the characteristics of autism-a finding which could point to new ways of helping anorexics overcome their illness.

A study by the leading autism expert Simon Baron-Cohen at Cambridge University`s Autism Research Centre found that compared to typical girls, those with anorexia have an above-average number of autistic traits.

They were also found to have an above-average interest in systems and order, and below-average scores in empathy-a profile similar, but less pronounced, to that seen in people with autism, suggesting the two disorders may have common underlying features, Baron-Cohen said.

"Traditionally, anorexia has been viewed purely as an eating disorder. This is quite reasonable, since the girls` dangerously low weight and their risk of malnutrition or even death has to be the highest priority," he said.

"But this new research is suggesting that underlying the surface behaviour, the mind of a person with anorexia may share a lot with the mind of a person with autism. In both conditions, there is a strong interest in systems. In girls with anorexia, they have latched onto a system that concerns body weight, shape, and food intake."

People with autism have varying levels of impairment across three main areas-social interaction and empathy or understanding, repetitive behaviour and interests, and language and communication.

Cohen noted that autism and anorexia share certain features, such as rigid attitudes and behaviours, a tendency to be very self-focused, and a fascination with detail. Both disorders also share similar differences in the structure and function of brain regions involved in social perception.

Overlooked

As many as one in 50 school age children in the United States are diagnosed with autism. In Europe experts say the rate is around one in 100 children. Most cases are diagnosed in boys.

But Bonnie Auyeung, who worked with Baron-Cohen on this latest research, said its findings suggested a proportion of females with autism may be being overlooked or misdiagnosed because doctors see them first with anorexia.

The study, published in the BioMed Central journal Molecular Autism, tested how 66 girls aged 12 to 18 with anorexia but without autism scored on tests to measure autistic traits.

The researchers compared them to more than 1,600 typical teenagers in the same age range, measuring their autistic traits using a score called the Autism Spectrum Quotient (AQ), their "systemising" using the Systemising Quotient (SQ), and their empathy using the Empathy Quotient (EQ).

They found that compared to typical girls on the AQ, five times more girls with anorexia scored in the range where people with autism score. On tests of empathy and systemising, girls with anorexia had a higher SQ, and a reduced EQ, a profile the researchers said parallels that seen in autism.

Tony Jaffa, who co-led the study, said acknowledging that some anorexic patients may also have a higher than normal number of autistic traits and a love of systems offer specialists new ideas for ways to treat people with the eating disorder.

"Shifting their interest away from body weight and dieting on to a different but equally systematic topic may be helpful," he said. "(And) recognizing that some patients with anorexia may also need help with social skills and communication, and with adapting to change, also gives us a new treatment angle."

Aug 07
Pregnancy length can vary naturally by as much as 5 weeks
A new study has found that the length of a human pregnancy can vary naturally by as much as five weeks.

Normally, women are given a date for the likely delivery of their baby that is calculated as 280 days after the onset of their last menstrual period.

Yet, only four percent of women deliver at 280 days and only 70 percent deliver within 10 days of their estimated due date, even when the date is calculated with the help of ultrasound.

Now, for the first time, researchers in the USA have been able to pinpoint the precise point at which a woman ovulates and a fertilised embryo implants in the womb during a naturally conceived pregnancy, and follow the pregnancy through to delivery.

Using this information, they have been able to calculate the length of 125 pregnancies.

"We found that the average time from ovulation to birth was 268 days - 38 weeks and two days," Dr Anne Marie Jukic, a postdoctoral fellow in the Epidemiology Branch at the National Institute of Environmental Health Sciences (Durham, USA), part of the National Institutes for Health, said.

"However, even after we had excluded six pre-term births, we found that the length of the pregnancies varied by as much as 37 days.

"We were a bit surprised by this finding. We know that length of gestation varies among women, but some part of that variation has always been attributed to errors in the assignment of gestational age. Our measure of length of gestation does not include these sources of error, and yet there is still five weeks of variability. It`s fascinating," she said.

The research is published online in Europe`s leading reproductive medicine journal Human Reproduction.

Aug 07
Bird flu 'pass between humans in China'
The first scientific analysis of probable human-to-human transmission of a deadly new strain of bird flu that emerged in China this year gives the strongest evidence yet that the H7N9 virus can pass between people, scientists said on Wednesday.

Research published in the British Medical Journal (BMJ) analyzing a family cluster of cases of H7N9 infection in eastern China found it was very likely the virus "transmitted directly from the index patient (a 60-year-old man) to his daughter."

Experts commenting on the research said while it did not necessarily mean H7N9 is any closer to becoming the next flu pandemic, "it does provide a timely reminder of the need to remain extremely vigilant."

"The threat posed by H7N9 has by no means passed," James Rudge and Richard Coker of the London School of Hygiene and Tropical Medicine said in a commentary in the same journal.

The scientists who led the study stressed, however, that the virus has not yet gained the ability to transmit from person to person efficiently - meaning the risk is very low that it could cause a human pandemic in its current form.

The new bird flu virus, which was unknown in humans until February, has so far infected at least 133 people in China and Taiwan, killing 43 of them, according to the latest World Health Organization (WHO) data.

Most cases have been in people who had visited live poultry markets or had close contact with live poultry in seven to 10 days before falling ill.

The BMJ study, lead by Chang-jun Bao at the Jiangsu Province Centre for Disease Control and Prevention, analyzed a family cluster of two H7N9 patients - a father and daughter - in Eastern China in March 2013.

The first "index" patient - a 60-year-old man - regularly went to a live poultry market and fell ill five to six days after his last exposure to poultry.

He was admitted to hospital on 11 March. When his symptoms became worse, he was transferred to an intensive care unit (ICU) on March 15 but died of multi-organ failure on May 4, the study reported.

The second patient, his healthy 32-year-old daughter, had no known exposure to live poultry but provided direct bedside care for her father in the hospital before he went to intensive care.

She developed symptoms six days after her last contact with her father and went into hospital on March 24. She was moved to the ICU on March 28 and died of multi-organ failure on April 24.

Strains of the virus isolated from samples taken from each patient were "almost genetically identical" - a strong suggestion that the virus was transmitted directly from father to daughter, the researchers said.

"To our best knowledge, this is the first report of probable transmissibility of the novel virus person-to-person with detailed epidemiological, clinical and virological data," they wrote.

Peter Horby of the Oxford University clinical research unit in Hanoi, Vietnam, who was not involved in this research, said the study raised the level of concern about H7N9 and reinforced the need for intensive surveillance.

Aug 06
Diabetes pill may have anti-ageing effects
A diabetes drug given in low doses may have anti-ageing effects, US scientists have said following an experiment with mice.

Scientists believe the drug, metformin, may mimic the effects of extreme calorie restriction.

Eating a very low calorie diet is thought to promote healthy ageing, BBC reported.

Rafael de Cabo of the National Institute on Ageing in Baltimore, Maryland, US, said calorie restriction in laboratory animals has shown to increase their lifespan.

However, the human implications of the study were unclear, the researchers said in the journal Nature Communications.

Metformin is a widely prescribed treatment for type-2 diabetes, which occurs mainly in people above the age of 40. It is also used to treat metabolic syndrome, a combination of diabetes, high blood pressure and obesity.

Earlier work has shown that metformin can extend the lifespan of simple organisms like worms, but studies in flies and mammals have given conflicting evidence.

The scientists gave one of two different doses of metformin to middle-aged male mice and found that lower doses increased lifespan by about five percent, and also delayed the onset of age-associated diseases.

But they said the higher dose of metformin was toxic and reduced the lifespan of mice, BBC reported.

De Cabo said further studies were needed to determine if metformin has any effect on human health and lifespan.

Aug 06
Breastfeeding reduces Alzheimer`s risk in women
Mothers who breastfeed run a lower risk of developing Alzheimer`s, with longer periods of breastfeeding further reducing the risk, a new study suggests.

The report suggests that the link may be to do with certain biological effects of breastfeeding.

For example, breastfeeding restores insulin tolerance which is significantly reduced during pregnancy, and Alzheimer`s is characterised by insulin resistance in the brain.

Although they used data gathered from a very small group of just 81 British women, the researchers observed a highly significant and consistent correlation between breastfeeding and Alzheimer`s risk. They argue that this was so strong that any potential sampling error was unlikely.

At the same time, however, the connection was much less pronounced in women who already had a history of dementia in their family.

The research team hope that the study - which was intended merely as a pilot - will stimulate further research looking at the relationship between female reproductive history and disease risk.
The study is published in the Journal of Alzheimer`s Disease.

Aug 03
A week of camping can help reset internal circadian clocks
Spending just one week camping out in the natural light is enough to synch the circadian clocks with the timing of sunrise and sunset, a new study has revealed.

The study, by University of Colorado Boulder, found that the synchronization happened in that short period of time for all participants, regardless of whether they were early birds or night owls during their normal lives.

"What`s remarkable is how, when we`re exposed to natural sunlight, our clocks perfectly become in synch in less than a week to the solar day," CU-Boulder integrative physiology Professor Kenneth Wright, who led the study, said.

Electrical lighting, which became widely available in the 1930s, has affected our internal circadian clocks, which tell our bodies when to prepare for sleep and when to prepare for wakefulness.

The ability to flip a switch and flood a room with light allows humans to be exposed to light much later into the night than would be possible naturally.

Even when people are exposed to electrical lights during daylight hours, the intensity of indoor lighting is much less than sunlight and the color of electrical light also differs from natural light, which changes shade throughout the day.

The study is published online in the journal Current Biology.

Aug 03
Anaemia boosts risk of dementia in elderly
Anaemia, or low levels of red blood cells, may increase the risk of dementia in elderly people, a US study has said.

"Anaemia is common in the elderly and occurs in up to 23 percent of adults aged 65 and older," Xinhua quoted study author Kristine Yaffe of the University of California San Francisco as saying.

"The condition has also been linked in studies to an increased risk of early death."

In the study, researchers examined 2,552 older adults between the ages of 70 and 79 for over 11 years.

Of those, 393 had anaemia at the start of the study. At the end of the study, 445, or about 18 percent of participants, developed dementia.

The study found that people who had anaemia at the start of the study had a nearly 41 percent higher risk of developing dementia than those who were not anaemic.

The link remained after considering other factors, such as age, race, sex and education, according to the study published in the US journal Neurology.

Of the 393 people with anaemia, 89 people (or 23 percent) developed dementia, compared to 366 of the 2,159 people (or 17 percent) who did not have anaemia, the study said.

"There are several explanations for why anaemia may be linked to dementia," Yaffe said.
"For example, anaemia may be a marker for poor health in general, or low oxygen levels resulting from anaemia may play a role in the connection. Reductions in oxygen to the brain have been shown to reduce memory and thinking abilities and may contribute to damage to neurons."

Aug 02
New approach for organ regeneration, tissue repair identified
Researchers including an Indian origin have identified an entirely new approach to enhance normal tissue growth.

Tissue regeneration is a process that is not fully understood, but previous research has demonstrated that endothelial cells lining the insides of small blood vessels play a key role in tissue growth. It is also known that these endothelial cells generate chemical messengers called epoxyeicosatrienoic acids (EETs), which stimulate blood vessel formation in response to tissue injury.

In this new research, first author Dipak Panigrahy, MD, an investigator in Beth Israel Deaconess Medical Center (BIDMC) Center for Vascular Biology Research, and his colleagues wanted to find out how EETs might participate in organ and tissue regeneration.

To find the answers, they created 7 different mouse models. The models focused on liver, kidney and lung regeneration; wound healing; corneal vascularization; and retinal vascularization.

Panigrahy, an Instructor in Pathology at Harvard Medical School. Administering synthetic EETs spurred tissue growth in the research models, said that the team used genetic and pharmacologic tools to manipulate EET levels in the animals to show that EETs play a critical role in accelerating tissue growth, providing the first in vivo demonstration that pharmacological modulation of EETs can affect organ regeneration.

The team also demonstrated that proteins called soluble epoxide hydrolase (sEH) inhibitors, known to elevate EET levels, promoted liver and lung regeneration. (sEH is the main metabolizing enzyme of EETs.)

Panigrahy asserted that their results offer a mechanistic rationale for evaluating sEH inhibitors as novel therapeutics for a number of human diseases such as hepatic insufficiency after liver damage and diseases characterized by immature lung development, such as bronchopulmonary dysplasia, adding that the use of topical sEH inhibitors on the skin might also be useful for the acceleration of wound healing.

The researchers suspected that EETs were stimulating tissue regeneration by way of blood vessel formation, specifically by producing vascular endothelial growth factor (VEGF) to promote vessel growth. As predicted, when the investigators depleted VEGF in the mice, EETs` effects on organ regeneration disappeared.

Mark Kieran, MD, PhD, of the Division of Pediatric Oncology at Dana-Farber/Boston Children`s Cancer and Blood Disorders Center, said that discovering EETs` role could be of critical importance to help control the repair of liver, lungs and kidneys.

Their findings have been published online in the Proceedings of the National Academy of Sciences (PNAS).

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