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Apr 06
Resistance spread 'compromising' fight against malaria
Scientists have found new evidence that resistance to the front-line treatments for malaria is increasing.

They have confirmed that resistant strains of the malaria parasite on the border between Thailand and Burma, 500 miles (800km) away from previous sites.

Researchers say that the rise of resistance means the effort to eliminate malaria is "seriously compromised".

The details have been published in The Lancet medical journal.

For many years now the most effective drugs against malaria have been derived from the Chinese plant, Artemisia annua. It is also known as sweet wormwood.

In 2009 researchers found that the most deadly species of malaria parasites, spread by mosquitoes, were becoming more resistant to these drugs in parts of western Cambodia.

This new data confirms that these Plasmodium falciparum parasites that are infecting patients more than 500 miles away on the border between Thailand and Burma are growing steadily more resistant.

The researchers from the Shoklo Malaria Research Unit measured the time it took the artemisinin drugs to clear parasites from the bloodstreams of more than 3,000 patients. Over the nine years between 2001 and 2010, they found that drugs became less effective and the number of patients showing resistance rose to 20%.

Prof Francois Nosten, who is part of the research team that has carried out the latest work, says the development is very serious.

"It would certainly compromise the idea of eliminating malaria that's for sure and will probably translate into a resurgence of malaria in many places," he said.
'Untreatable malaria'

Another scientist involved with the study is Dr Standwell Nkhoma from the Texas Biomedical Research Institute.

"Spread of drug-resistant malaria parasites within South East Asia and overspill into sub-Saharan Africa, where most malaria deaths occur, would be a public health disaster resulting in millions of deaths."

The scientists cannot tell if the resistance has moved because mosquitoes carrying the resistant parasites have moved to the Burmese border or if it has arisen spontaneously among the population there. Either way the researchers involved say it raises the spectre of untreatable malaria.

"Either the resistance has moved and it will continue to move and will eventually reach Africa. Or if it has emerged, now that artemisinin is the standard therapy worldwide then it means it could emerge anywhere," Prof Nosten told the BBC.

"If we were to lose artemisinin then we don't have any new drugs in the pipeline to replace them. We could be going back 15 years to where cases were very difficult to treat because of the lack of an efficacious drug."

Artemisinin is rarely used on its own, usually being combined with older drugs to help fight the rise of resistance. These artemisinin based combination therapies are now recommended by the World Health Organization as the first-line treatment and have contributed substantially to the recent decline in malaria cases in many regions.

Prof Nosten says the current spread of resistance could be similar to what happened in the 1970s with chloroquine, a drug that was once a front-line treatment against the disease.

"When chloroquine resistance reached Africa in the middle of the 1970s it translated into a large increase in the number of cases and the number of children who died increased dramatically."

In a separate paper published in the journal Science researchers have identified a region of the malaria parasite genome that is linked to resistance to artemisinin.

Dr Tim Anderson, from Texas Biomed who led this study, says that while mapping the geographical spread of resistance can be challenging it may be hugely beneficial.

"If we can identify the genetic determinants of artemisinin resistance we should be able to confirm potential cases of resistance more rapidly. This could be critically important for limiting the further spread of resistance."

According to the World Malaria Report 2011 malaria was responsible for killing an estimated 655,000 people in 2010 - more than one every minute. A majority of these were young children and pregnant women.

Apr 06
Women who fall pregnant when they're dieting 'more likely to have obese child'
Women who fall pregnant while dieting are more likely to have a child that could become obese or diabetic in later life, a study suggests.

Researchers found in a study on sheep that giving ewes less food at the time of conception caused DNA changes in the brains of their young.

The University of Manchester scientists suspect the findings may hold true for humans as well and could explain why twins are more likely to develop Type 2 diabetes in adulthood.

The study investigated twin pregnancies in sheep as well the pregnancies of ewes that received less food around the time the lamb was conceived.

The researchers then looked at tissues from the brains of the unborn lambs to see if there were changes in the structure of the DNA.

Study leader Anne White said: 'We found that unborn twin lambs had changes in the structure of DNA in the region of the brain that regulates food intake and glucose that resulted in an increased chance of diabetes in adulthood.

'Our findings provide a reason why twins are more likely to get diabetes but we have also shown that mothers who don't have enough food around the time of conception may have a child who grows up with an increased risk of obesity.'

The researchers believe their findings are relevant to humans as they reveal a non-genetic, or 'epigenetic', way in which the DNA of offspring can be altered.

Professor White added: 'Our study is important because it shows that factors in the brain can be altered by non-hereditary mechanisms and this results in changes in the body, which could make people obese.

'The findings may provide a new understanding of why twins can develop diabetes and also suggests that dieting around the time a baby is conceived may increase the chance of the child becoming obese later in life.'

More and more people are becoming obese and getting diabetes, while rates of twins are steadily increasing as women have babies at older ages and rates of conception using artificial reproductive technologies increase.

Dieting in young women is also very common and can occur in women who may not know they are pregnant.

The team's findings in sheep, if replicated in humans, suggest that obesity and diabetes could be more likely in twins and in children from mothers who aren't eating properly, or dieting, around the time of conception.

Researchers say it could affect the advice giving to women who are planning a family to reduce future health risks for their children.

The study was published in the Journal of the Federation of American Societies for Experimental Biology.

Apr 05
Tobacco's the biggest cause of cancers in India
Tobacco is addictive, causes cancer and is killing nearly 1.2 lakh young Indians. Two major studies were released in the past week. A study in the Lancet, and the World Tobacco Atlas both found that tobacco use is the single biggest cause of cancers in India, resulting in 40 per cent of cancer deaths in Indian men.

Eighty per cent of all oral cancers are tobacco-related, according to the World Tobacco Atlas, released by world lung foundation. The Lancet study highlighted six lakh deaths due to cancer, in 2010.

One fifth of these were due to tobacco use. The study also highlighted how cancer was hitting Indians at a younger age, than their counterparts in the West.

DRD WHO SEARO Dr Poonam Khetrapal Singh said, "The young are taking more to tobacco now. Despite all the attempts that have been made we don't find that that is on the decline now."

There is a regional variance. The North-East has four times higher cancer rates than neighbouring states Bihar and Orissa, possibly because of high tobacco consumption.

Cervical cancer is responsible for 20 per cent of all cancer deaths in women. These can also be caught at an early stage, through regular screening or pap smear tests.

Apr 05
Diabetes poses risk for moms to be
While motherhood is painted as the crowning glory and privilege of being a woman, it comes with its own inherent problems which can make a new mother feel upset, like a failure and insecure about her abilities and choices. The journey of development of the kid in the womb is by far the most precious feeling that any woman can ever experience, but at times it leaves behind the care taker and her offspring with lifelong diseases.

Diabetes in pregnant women is of two types:
Gestational diabetes that is diagnosed during pregnancy

Pre-gestational or pre existing diabetes (type 1 or type 2 diabetes) diagnosed before pregnancy.

Diabetes in pregnant women occurs in about 1 in 20 pregnancies. It usually begins between weeks 13 to 28 of pregnancy and goes away with the pregnancy. Hormonal changes and weight gain are part of a healthy pregnancy, but these changes can sometimes take toll on the body.

Gestational diabetes is a condition where your blood sugar levels are high. This occurs only when you are pregnant. It is one of the most common health problems faced by pregnant women. It usually develops in the middle of the pregnancy, between the 24th and 28th weeks, when hormones interfere with the mother's ability to use insulin" says Dr. Ajay Aggarwal, Consultant Endocrinologist, Fortis Hospital, Shalimarbagh, Delhi.

Whereas, if you have diabetes before you get pregnant, it is called Pre gestational diabetes. The two types of pre gestational diabetes are:

When body requires more energy than usual and the normal amount of glucose from the food intake is not sufficient. To compensate this, the pancreas makes more and more insulin. But if insulin is not produced in the right amount, i.e. or due to malfunction of the pancreas insulin is not produced, the glucose can't get into the cells, and thus stays and keeps accumulating in the blood making your blood glucose level higher than required causing diabetes. Diabetes, if not taken seriously can lead to blindness, chronic heart diseases, stroke, kidney failure and also sometimes to amputations.

Many people are unaware of the fact that diabetes can be dangerous for pregnant woman. Diabetes, if not controlled can affect your baby. It can cause your baby to grow large (macrosomia) and have a higher birth weight (nearly 4 kg). This can make normal delivery (vaginal delivery) difficult. Uncontrolled diabetes can also put your baby at an increased risk for breathing, low blood sugar levels after delivery and jaundice (yellowing of the skin and eyes) tells Dr. Aggarwal.

If a mother bearing a child is diabetic or develops diabetes due to hormonal changes, there are chances that the baby can acquire diabetes too. The baby also stands chances to be born with defects!

Diabetes in pregnant women can lead to a number of complications for both mother and the child.

Some of the complications which can affect the mother are:

High blood pressure resulting in fits, in medical terminology Pre-eclampsia

Increase in the amount of amniotic fluid; the fluid around baby in the womb.

Pre mature birth of baby up to almost 37 weeks before the actual due date.

Have to under-go a caesarean birth because of complications

Chances of developing Gestational diabetes in future pregnancies.

Risks of developing type II diabetes in later stages of life.

Possible effects on the baby:

Probability of the baby acquiring low blood sugar (hypoglycaemia) for a few days after birth.

A more than higher risk of the baby getting jaundice, which is otherwise common in all newborns.

If the baby is born prematurely, there is a higher chance of his or herfound with the condition of respiratory distress syndrome as the lungs do not get a chance to get developed fully as a result of the high sugar levels during pregnancy.

The child stands a higher chance of being obese in later life.

Also face a clear risk of developing diabetes when the child grows older.

So, the big question is, "How to take care of yourself during pregnancy so that you do not get diagnosed with this type of diabetes, and if you have nonetheless acquired it, how do you make sure that the baby is least effected?"

Though diabetes in pregnant women should be considered a big threat to the baby's health, it is also a fact that there are numerous cases when women with gestational diabetes have delivered healthy babies. So, it is all about taking few precautions during pregnancy. Here are a few things which one should keep in mind and follow:

Follow the diet plan suggested by your dietician very strictly.

Try to be active for at least 2 hours and 30 minutes each week. This will help in keeping your blood glucose level on track.

Use a blood glucose meter to check your blood glucose levels periodically.

It is very important to keep track of your blood sugar level so that you know exactly when it is dropping below the required level and you take the necessary precautions and prescribed medicines.

Dr. Aggarwal "Treatment of choice for Diabetes in Pregnancy is Only Insulin. OHA's are contraindicated. Insulin therapy helps to maintain your blood sugar levels in the normal range. Maintaining your blood sugar levels in the normal range will help your baby have the right weight. It will also prevent preterm labor, miscarriages and help you to have a good pregnancy outcome.

Insulin pumps help you manage diabetes by delivering insulin 24 hours. Pump is more beneficial as it is more accurate, precise and flexible as insulin delivery systems and provides tight blood glucose control therefore preventing both the mother and the baby from complications.

Insulin Pump is superior over Insulin Injections as it:-

Delivers insulin more accurately than injections

Eliminates individual insulin injections ( 12-16 Injections Vs one prick/ every 4th day)

Improves HBA1c

Results in fewer large swings in your blood glucose levels (reduces episodes of hypoglycemia and hyperglycemia)

Allows you to be flexible about when and what you eat

Can improve your quality of life

Reduces complications related to diabetes to mother as well as the baby

Better predictability for insulin absorption

Allows you to exercise without having to eat large amounts of carbohydrate

The number of people using this new insulin pump therapy to manage their diabetes is growing rapidly. Today, over 250,000 people around the world are using an insulin pump to get a control on their unpredictable fluctuations of sugar level.

All you would-be moms, do not worry, just be careful. You only need to keep a close check on your blood glucose level and enjoy the phase.

Apr 04
Patterns: Alcohol May Help Heart Attack Survivors
It's well established that moderate alcohol consumption may ward off heart disease. But even after a heart attack, an alcoholic drink a day may be good for a man's health, a new study has found.

Researchers followed 1,818 men who survived heart attacks for up to 20 years. Every two years the men reported on their health, and every four years they filled out a detailed diet questionnaire that recorded, among many other things, their alcohol consumption.

There were 468 deaths over the course of the study, which was published last week in the European Heart Journal.

After controlling for smoking, body mass index, diabetes, hypertension, aspirin use and other factors, the researchers found that, compared with abstainers, men who drank one or two glasses of beer or wine daily, or one or two shots of liquor, were 34 percent less likely to die from any cause and 42 percent less likely to die of cardiovascular disease.

Men who had slightly less than a drink a day had a 22 percent lower risk of death, but the benefit disappeared among those who had three or more drinks a day.

"The maximum benefit is seen at moderate levels," said Jennifer K. Pai, the lead author and an assistant professor of medicine at Brigham and Women's Hospital and the Harvard School of Public Health. "We're not telling people to drink if they don't already. But we can say that continuing to drink moderate amounts after a heart attack seems to be beneficial."

Apr 04
Bees self medicate 'when infected with pathogens'
Honey bees are clever than you thought. They "self medicate" when their colony is infected with a harmful fungus, bringing in increased amounts of antifungal plant resins to ward off the pathogen.

"The colony is willing to expend the energy and effort of its worker bees to collect these resins. So, clearly this behaviour has evolved because the benefit to the colony exceeds the cost," Michael Simone Finstrom at North Carolina State University, who led the study, said.

Wild honey bees normally line their hives with propolis, a mixture of plant resins and wax that has antifungal and antibacterial properties. Domesticated honey bees also use propolis, to fill in cracks in their hives.

However, researchers found that, when faced with a fungal threat, bees bring in significantly more propolis 45 percent more, on average. The bees also physically removed infected larvae that had been parasitized by the fungus and were being used to create fungal spores.

Propolis is an effective antifungal agent because they lined some hives with a propolis extract and found that the extract significantly reduced the rate of infection.

And, apparently bees can sometimes distinguish harmful fungi from harmless ones, since colonies did not bring in increased amounts of propolis when infected with harmless fungal species. Instead, the colonies relied on physically removing the spores.

However, the self-medicating behaviour does have limits. Honey bee colonies infected with pathogenic bacteria did not bring in significantly more propolis despite the fact that the propolis also has antibacterial properties.

"There was a slight increase, but it was not statistically significant. That is something we plan to follow up on," Simone Finstrom said in a release.

Apr 03
Few pegs make people seem more enticing
Scientists may have the answer to why the opposite sex seems more enticing after a few pegs - they found that alcohol clouded women's judgement.

Researchers at London's Roehampton University asked more than 100 men and women to rate pairs of faces. Some did the tests while drinking a strong vodka and tonic. Others were given a similar-tasting non-alcoholic drink or orange squash.

One of the tests involved looking at faces and stating whether they thought each one was symmetrical or non-symmetrical. Symmetry is known to be tied to attraction, with a face in which one half mirrors the other seen as a sign of good genes and good health, the journal Addiction reports.

The men and women given the vodka and tonic found it more difficult to work out if a face was symmetrical than those on soft drinks, according to the Daily Mail.

Roehampton researcher Lewis Halsey said: "People that had drink tended to be less good at noticing if a face was asymmetrical, they often saw it as being symmetrical when it was asymmetrical."

Halsey said: "What we have shown is that people's ability to detect symmetry is part of the explanation for the beer goggle effect. The consequences could be considerable.

"A lot of people say they met their partner when they were drunk. Are their marriages shorter or longer lasting? Does it change the nature of the relationship?"

A Bristol University study found people do appear more attractive to both sexes after they've had a drink - and it takes as little as a pint and a half of beer. In some cases, the mere anticipation of alcohol may be enough to alter judgement.

Apr 03
Highest number of cancer deaths among India's youth
Tobacco is addictive, causes cancer and is killing nearly 1.2 lakh young Indians. Two major studies were released in the past week. A study in the Lancet, and the World Tobacco Atlas both found that tobacco use is the single biggest cause of cancers in India, resulting in 40 per cent of cancer deaths in Indian men.

Eighty per cent of all oral cancers are tobacco-related, according to the World Tobacco Atlas, released by world lung foundation. The Lancet study highlighted six lakh deaths due to cancer, in 2010.

One fifth of these were due to tobacco use. The study also highlighted how cancer was hitting Indians at a younger age, than their counterparts in the West.

DRD WHO SEARO Dr Poonam Khetrapal Singh said, "The young are taking more to tobacco now. Despite all the attempts that have been made we don't find that that is on the decline now."

There is a regional variance. The North-East has four times higher cancer rates than neighbouring states Bihar and Orissa, possibly because of high tobacco consumption.

Cervical cancer is responsible for 20 per cent of all cancer deaths in women. These can also be caught at an early stage, through regular screening or pap smear tests.

Apr 02
Your dog at office could be a great stress buster: Research
Taking your dog to the office could act as a real stress buster and also promote goodwill, new research says.

Stress is known to contribute to employee absenteeism, morale and burnout, eroding productivity and resources, according to Virginia Commonwealth University researchers.

They compared employees who bring their dogs to work and those who don't and those without pets and how it impacted stress, job satisfaction, organizational commitment and support, the International Journal of Workplace Health Management reports.

"Dogs in the workplace can make a positive difference," said principal investigator Randolph T. Barker, professor of management at the Virginia School of Business.

"The differences in perceived stress between days the dog was present and absent were significant. The employees as a whole had higher job satisfaction than industry norms," added Barker, according to a Virginia statement.

The study took place at Replacements, Ltd., a service-manufacturing-retail company located in Greensboro, North Carolina, which employs approximately 550 people.

The team noted that stress significantly rose during the day when owners left their dogs at home compared to days they brought them to work.

For example, Barker said, employees without a dog were observed requesting to take a co-worker's dog out on a break. These were brief, positive exchanges as the dogs were taken and returned and also resulted in an employee break involving exercise.

Other findings revealed mostly positive comments from employees such as "pets in the workplace can be a great bonus for employee morale," "having dogs here is great stress relief" and "dogs are positive; dogs increase co-worker cooperation."

Apr 02
How to spot if someone is lying to you? Just ask your computer
Trying to tell whether someone is lying to you can often prove difficult.

But now with the aid of a computer, the need to look for tell-tale signs could soon be made redundant.

Scientists have developed a new software that focuses solely on the subject's eyes, monitoring the movements of the pupils, which determines if someone is telling you the truth or attempting to pull the wool over your eyes.

Researchers at the University of Buffalo recorded a series conversations in which a number of lies were told.

And having tested their program against a trained human interrogator, they found that the software had a higher success rate.

While the specially-trained examiner correctly identify 65% of false statements, the computer recorded an impressive 82.5% reading.

Assistant professor Ifeoma Nwogu said: 'What we wanted to understand was whether there are signal changes emitted by people when they are lying, and can machines detect them?'

The study centred around conversations in which subjects could chose whether or not to steal a cheque, before later being questioned on their decision.

A wide range of individuals were selected, with varying skin colours, age and height with someone even wearing glasses in an attempt to conceal their lies.

Despite most of those interviewed being caught out, there were a select number who managed to keep their eye movements to a bare minimum, which consequently resulted in the wrong conclusions.

Now scientists plan to carry out additional studies on a larger scale, with a long-term view to developing a system that could work alongside human interrogators.

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