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Jul 03
Don't save for future? You may also be ignoring health
If you are not inclined to save for the future, you may also have a tendency to ignore your health as researchers have found that poor physical health and financial health are driven by the same underlying psychological factors.

The decision to contribute to a retirement plan predicted whether or not an individual will act to correct poor physical health indicators, the findings showed.

Insufficient retirement funds and chronic health problems are at least partially driven by the same time discounting preferences, the researchers showed.

"We find that existing retirement contribution patterns and future health improvements are highly correlated," said Lamar Pierce, associate professor of strategy at Washington University in St. Louis in the US.

The study appeared in the journal Psychological Science.

Jul 03
High tax on tobacco will safeguard citizens: Health groups
Health Minister Harsh Vardhan's proposal to the finance ministry on increasing taxes on tobacco products in the upcoming budget was Wednesday welcomed by various health groups, who said the increase in taxes will help in safeguarding the health of the people.

Harsh Vardhan recently wrote to Finance Minister Arun Jaitley for an increase in tax on the retail price of cigarettes from 45 percent to 60 percent in the union budget to be presented in parliament July 10.

"Raising taxes on tobacco products is the single-most effective way to reduce tobacco use and save lives in India. All tobacco products in India are under-taxed," said Bhavna Mukhopadhyay of the Voluntary Health Association of India (VHAI), welcoming the move of the health minister.

She said that increasing taxes means increase in revenue, reduction in consumption and saving of lives. It will also reduce the state's burden of treatment cost.

The World Health Organisation (WHO) has recommended that the share of excise tax for tobacco products should be increased to 70 percent of the retail price.

"A tax increase that raises prices of tobacco products by 10 percent is estimated to reduce tobacco consumption by 4-5 percent. Essentially, as tax goes up, death and disease goes down. It is good for people's health and good for the economy," said Nata Menabde, WHO representative to India.

She said that raising taxes was one of the strongest weapons to fight tobacco and this was what the WHO Framework Convention on Tobacco Control mandates.

According to a combined study by the health ministry and WHO, it is estimated that the total economic costs attributable to tobacco use from all diseases in India in the year 2011 amounted to a staggering Rs.1,04,500 crore - 12 percent more than the combined state and central government expenditure on health care in the same year.

Pankaj Chaturvedi, head and neck surgeon at the Tata Memorial Hospital in Mumbai, says tobacco is the "cheapest poison in the market that getting cheaper every year".

"Tobacco taxes in India are not regularly adjusted for inflation, and over time tobacco products are becoming increasingly affordable, leading to one million deaths annually in India due to tobacco related diseases."

According to the Global Adult Tobacco Survey India (GATS) 2010, more than one-third (35 percent) of adults in India use tobacco in some form or the other.

Jul 02
Malaria makes you smell delicious to mosquitoes
Malaria may alter the way people smell to make them more alluring to mosquitoes, according to a new finding that can help detect the deadly disease non-invasively through body odour.

An infection with malaria pathogens changes the scent of infected mice, making those infected more attractive to mosquitoes, researchers have found.

Malaria is and remains a formidable disease that is transmitted to humans by the anopheles mosquito. The pathogen is a protozoan of the genus Plasmodium. If left untreated, malaria can be deadly.

In order to complete its life-cycle, the plasmodium parasite must eventually be acquired by another mosquito, which occurs when the insect bites an infected person.

In a new study, researchers from ETH Zurich and Pennsylvania State University show that the plasmodium parasite appears to manipulate its host by changing the characteristics of the infected individual's body odour, which makes the carrier more attractive to hungry mosquitoes.

Mosquitoes were most attracted to infected mice with a high concentration of gametocytes, the plasmodium parasite's reproductive cells, in their blood.

When the mosquito consumes these cells along with the blood, a new development cycle starts in the mosquito's gut.

However, the pathogens do not appear to trigger the expression of unique scent components.

"There appears to be an overall elevation of several compounds that are attractive to mosquitoes," said Consuelo De Moraes, from ETH Zurich.

The researchers believe it is logical that infected people smell more attractive but do not form highly specific body odours, especially given that the malaria pathogen can also have adverse effects on mosquitoes.

"Since mosquitoes probably don't benefit from feeding on infected people, it may make sense for the pathogen to exaggerate existing odour cues that the insects are already using for host location," said study leader Mark Mescher.

What researchers found most surprising is the fact that the malaria infection leaves its mark on body odour for life.

Even when infected mice no longer had symptoms, their body odour showed that they were carriers of the pathogen.

However, not all stages of the disease smelled the same: the scent profile of the acutely ill differs from the profile found in individuals exhibiting later stages of malaria infection.

Although the findings cannot be directly transferred to human malaria, they suggest that similar effects might be involved in the attraction of mosquitoes to infected people.

In addition to aiding efforts to disrupt malaria transmission by mosquitoes, researchers hope that findings may also be used to develop new non-invasive diagnostic procedures that would facilitate effective screening of human populations for malaria infections, particularly in order to identify individuals who don't otherwise have symptoms but remain capable of spreading the disease.

The study was published in the journal PNAS.

Jul 02
Mice study helps calculate aggressiveness of human oral cancer
Researchers can now foresee the aggressiveness of cancer tumors in people, thanks to a study which was being done on mouth cancer in mice.

Ravindra Uppaluri, MD, PhD, said that all patients with advanced head and neck cancer got similar treatments, and they were interested in finding out why some of the patients do well on standard combinations of surgery, radiation and chemotherapy, while some don't.

Washington University School of Medicine in St. Louis investigators found a consistent pattern of gene expression associated with tumor spreading in mice, and Uppaluri said that though they didn't automatically assume this mouse model would be relevant to human oral cancer, it turned out to be highly reflective of the disease in people.

The researchers, including first author Michael D. Onken, PhD, research assistant professor of cell biology and physiology, showed that exposure to a carcinogen sometimes produced tumors in the mice that did not spread, but other times resulted in aggressive metastatic tumors, similar to the variety of tumors seen in people.

Uppaluri's team then collaborated with Elaine Mardis, PhD, and compared their mouse sequences to human data sets from 'The Cancer Genome Atlas' (TCGA) and found that a lot of the genetic mutations present in mouse tumors were also found in human head and neck cancers.

Further analysis identified a common signature in the expression of about 120 genes that was associated with the more aggressive tumors, whether in mice or people. Subsequently, using oral cancer samples from patients treated at Washington University, researchers developed a proof of concept test from their signature that identified the aggressive tumors with about 93 percent accuracy.

The findings are reported in Clinical Cancer Research.

Jul 01
Early stress can have lasting negative impacts in children
A new study reveals that early exposure to stress can change the parts of developing children's brain.

The study, published in the journal Biological Psychiatry, found that chronic, toxic stress like poverty, neglect and physical abuse can have lasting negative impacts in children.

These kinds of stressors, experienced in early life, might change the parts of developing children's brains responsible for learning, memory and the processing of stress and emotion, researchers said.

These changes may be tied to negative impacts on behaviour, health, employment and even the choice of romantic partners later in life, they said.

The study, carried out by the researchers at the University of Wisconsin-Madison, was based on data from 128 children, aged around 12 years, who had experienced physical abuse, neglect or poverty early in life or came from low socio-economic status households.

Researchers conducted extensive interviews with the children and their caregivers, documenting behavioural problems and their cumulative life stress. The team also took brain scans of the children and compared them with brain scans of other children growing up in middle-class families who had not been maltreated.

Researchers found that children exposed to stress had changes in the amygdalas than children who had not.

They also found that children from low socio-economic status households and children who had been physically abused also had smaller hippocampal volumes. Putting the same images through automated software showed no effects.

Behavioural problems and increased cumulative life stress were also linked to smaller hippocampus and amygdala volumes.

Jul 01
Older sperm donors as good as young: Study
Sperm donors up to the age of 45 are just as likely to conceive children as those in their 20s, new research led by Indian-origin doctors has found.

Despite emerging evidence of a decline in sperm quality with increasing age, an analysis of every first fertility treatment cycle performed in the UK using sperm donation shows that outcome in terms of live birth is not affected by the age of the sperm donor.

Results from the study, said its principal investigator Dr Meenakshi Choudhary, from the Newcastle Fertility Centre at Life, UK, reaffirm the observation that a couple's fertility appears significantly more dependent on the age of the female partner than on that of the male.

From a total of more than 230,000 sperm donation cycles in the study, 39,282 were from a first cycle of treatment (with either IVF or donor insemination) and were included in the analysis.

With the assumption that female fertility clearly declines with age, the study divided its female subjects into two groups: those who were treated with donor sperm between the ages of 18 and 34, and those who were treated after the age of 37.

Researchers found live birth rate from IVF with donated sperm was around 29 per cent in the 18-34 age group, but only around 14 per cent in the over-37 age group.

However, within these same two female age bands, no significant differences were found in live birth rate (LBR) relative to the age of sperm donor.

In the younger IVF patients LBR was 28.3 per cent with a sperm donor aged under 20 and 30.4 per cent with a donor aged 41-45 while as in the younger donor insemination patients LBR was 9.7 per cent with a donor aged under 20 and 12 per cent with a donor aged 41-45.

There was a trend, for example, that sperm donors under the age of 20 were associated with a less successful outcome than older donors.

In the older IVF patients LBR was 11 per cent with a donor under the age of 20, 17 per cent with donor aged 26-30, and 16.6 per cent with a donor aged 41-45, while as in the older donor insemination patients LBR was 3.1 per cent with a donor under 20, and 4.6 per cent with a donor aged 41-45.

"Despite these trends, it's important to note that the impact of sperm donor age on live birth failed to reach statistical significance in any of the age groups we studied," said Choudhary.

"Our results suggest that, up to the age of 45, there is little effect of male age on treatment outcome, but sperm donors are a selected population based on good sperm quality.

"This confirms the view that a man's age doesn't matter in achieving a live birth provided his sperm quality is good," Choudhary said.

The results of the study were presented at the Annual Meeting of European Society of Human Reproduction and Embryology (ESHRE) in Munich by Choudhary's colleague, Commonwealth Clinical Fellow Dr Navdeep Ghuman.

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