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Sep 06
The secret of beating fear? Just talk about your emotions, say researchers
Simply describing your feelings at stressful times can make you less anxious, researchers have claimed.

UCLA research into people who were terrified of spiders found that by simply talking about their fear, they were able to deal with it - and even touch a tarantula.

The psychologists asked 88 people with a fear of spiders to approach a large, live tarantula in an open container outdoors.

The participants were told to walk closer and closer to the spider and eventually touch it if they could.

The subjects were then divided into four groups and sat in front of another tarantula in a container in an indoor setting.

In the first group, the subjects were asked to describe the emotions they were experiencing and to label their reactions to the tarantula - saying, for example, 'I'm anxious and frightened by the ugly, terrifying spider.'

'This is unique because it differs from typical procedures in which the goal is to have people think differently about the experience - to change their emotional experience or change the way they think about it so that it doesn't make them anxious,' said Michelle Craske, a professor of psychology at UCLA and the senior author of the study.

'Here, there was no attempt to change their experience, just to state what they were experiencing.'

In a second group, the subjects used more neutral terms that did not convey their fear or disgust and were aimed at making the experience seem less threatening.

They might say, for example, 'That little spider can't hurt me; I'm not afraid of it.'

'This is the usual approach for helping individuals to confront the things they fear,' Craske said.

In a third group, the subjects said something irrelevant to the experience, and in a fourth group, the subjects did not say anything - they were simply exposed to the spider.

'All the participants were re-tested in the outdoor setting one week later and were again asked to get closer and closer to the tarantula and potentially touch it with a finger.

The researchers measured how close subjects could get to the spider, how distressed they were and what their physiological responses were, focusing in particular on how much the subjects' hands sweated, which is a good measure of fear, Craske said.

The researchers found that the first group did far better than the other three.

These people were able to get closer to the tarantula - much closer than those in the third group and somewhat closer than those in the other two groups - and their hands were sweating significantly less than the participants in all of the other groups.

The results are published in the online edition of the journal Psychological Science and will appear in an upcoming print edition.

'They got closer and they were less emotionally aroused,' Craske said.

'The differences were significant.

'The results are even more significant given the limited amount of time involved.

'With a fuller treatment, the effects may be even larger.

'Exposure is potent,' she added. 'It's surprising that this minimal intervention action had a significant effect over exposure alone.'

'If you're having less of a threat response, which is indicated by less sweat, that would allow you to get closer; you have less of a fear response,' said study co-author Matthew Lieberman, a UCLA professor of psychology and of psychiatry and biobehavioral sciences.

'When spider-phobics say, 'I'm terrified of that nasty spider,' they're not learning something new; that's exactly what they were feeling - but now instead of just feeling it, they're saying it. For some reason that we don't fully understand, that transition is enough to make a difference.'

The scientists also analyzed the words the subjects used.

'Those who used a larger number of negative words did better, in terms of both how close they were willing to get to the tarantula and their skin-sweat response.

'In other words, describing the tarantula as terrifying actually proved beneficial in ultimately reducing the fear of it.'

Sep 06
Just one abortion could lead to women giving birth prematurely later in life
Having just one abortion could raise the risk of potentially life-threatening problems in future pregnancies, young women were warned last night.

Those who terminate their first pregnancy could be risking not only their own health but that of their next baby, a study has found.

They are at higher risk of a range of problems, from their next child being born prematurely to pre-eclampsia, a complication of pregnancy that can be fatal to mother and baby.

Crucially, just one abortion appeared to be enough to do the damage, with subsequent terminations not being any more dangerous.

This differs from previous studies that found the risks rise with each abortion.

Most of the risks were linked to surgical abortions and not those that use pills, which are becoming increasingly common.

Almost 200,000 abortions are carried out in England and Wales each year, with the highest rates among women in their late teens and early 20s. In Scotland, 40 per cent of around 13,000 abortions are carried out in the under-25s.

Abortion has been linked to premature births before but some previous studies have been small and the results have been mixed.

To build a clearer picture, researchers at Aberdeen University analysed the medical records of more than 600,000 Scottish women, including many who had aborted their first baby.

The data, spanning three decades, showed a woman who had an abortion the first time she conceived was 37 per cent more likely to give birth prematurely the next time she became pregnant, compared with one who was having her first child.

She was also 67 per cent more likely to give birth early than a woman who had already started her family.

However, the risks were still lower than those faced by a woman who had suffered a miscarriage, the British Science Festival in Aberdeen heard.

A woman who aborted her first pregnancy was also at higher risk of having a baby of low weight and of developing pre-eclampsia than one who was pregnant for the first time or already had a child.

Pre-eclampsia causes high blood pressure, blood clots and kidney damage, and leads to the deaths of up to 1,000 babies and at least six mothers a year.

Medical abortions using pills are normally used early in pregnancy and account for almost half of terminations in England and Wales, and 70 per cent in Scotland.

Researcher Professor Siladitya Bhattacharya said surgical abortions may be more likely to damage the womb, leading to later problems.

He added women seeking abortions should be made aware of the potential risks and medical terminations should be available to all who would benefit from them.

The British Pregnancy Advisory Service, which carries out almost a third of abortions in the UK, says the leaflets it gives to patients mention the link with premature birth.

But they do not say abortion is the cause because some of the reasons women choose to terminate a pregnancy such as unemployment, smoking or poor diet are also linked to early births.

However, Philippa Taylor of the Christian Medical Fellowship said: 'This study confirms many previous findings... that all show a clear link between abortion and an increased risk of a later pre-term birth.'

Sep 05
The pacemaker that can fit on a pinhead: Researchers unveil tiny implants that could revolutionise m
A wireless medical implant that could replace pacemakers with a gadget small enough to fit on the head of a pin has been shown off.

A team of engineers at Stanford has demonstrated the feasibility of a super-small, implantable cardiac device that gets its power not from batteries, but from radio waves transmitted from outside the body.

The breakthrough could lead to a plethora of new medical sensors and even 'smart pill' that can be swallowed without having to include batteries.

The implanted device is contained in a cube just eight-tenths of a millimeter in radius, and could fit on the head of pin.

It is hoped they could revolutionise medicine by allowing devices such as pacemakers to be implanted without the need for large battery packs which need surgery to replace them.

Instead, wearers would wear wireless battery packs which transmit power to the implant.

"Wireless power solves both challenges," said Ada Poon, a professor of electrical engineering at Stanford, who led the research.

Last year, Poon made headlines when she demonstrated a wirelessly powered, self-propelled device capable of swimming through the bloodstream.

The findings were published in the journal Applied Physics Letters.

Beyond the heart, they believe such devices might include swallowable endoscopes so-called "pillcams" that travel the digestive tract permanent pacemakers and precision brain stimulators; virtually any medical applications where device size and power matter.

In their paper, the researchers demonstrated wireless power transfer to a millimeter-sized device implanted five centimeters inside the chest on the surface of the heart a depth once thought out of reach for wireless power transmission.

The device works by a combination inductive and radiative transmission of power.

Both are types of electromagnetic transfer in which a transmitter sends radio waves to a coil of wire inside the body.

The radio waves produce an electrical current in the coil sufficient to operate a small device.

'For implantable medical devices, therefore, the goal is a high-frequency transmitter and a small receiver, but there is one big hurdle,' said Kim.

Existing mathematical models have held that high frequency radio waves do not penetrate far enough into human tissue, necessitating the use of low-frequency transmitters and large antennas too large to be practical for implantable devices.

However, this turned out to be untrue.

'In fact, to achieve greater power efficiency, it is actually advantageous that human tissue is a very poor electrical conductor,' said Kim.

'If it were a good conductor, it would absorb energy, create heating and prevent sufficient power from reaching the implant.'

According to their revised models, the researchers found that the maximum power transfer through human tissue occurs at about 1.7 billion cycles per second.

'In this high-frequency range, we can increase power transfer by about ten times over earlier devices.'

The discovery meant that the team could shrink the receive antenna by a factor of ten as well, to a scale that makes wireless implantable devices feasible.

At that the optimal frequency, a millimeter-radius coil is capable of harvesting more than 50 microwatts of power, well in excess of the needs of a recently demonstrated eight-microwatt pacemaker.

Sep 05
Organic food no healthier than non-organic: study
Organic produce and meat typically isn't any better for you than conventional varieties when it comes to vitamin and nutrient content, according to a new review of the evidence.

But organic options may live up to their billing of lowering exposure to pesticide residue and antibiotic-resistant bacteria, researchers from Stanford University and the Veterans Affairs Palo Alto Health Care System found.

"People choose to buy organic foods for many different reasons. One of them is perceived health benefits," said Dr. Crystal Smith-Spangler, who led the new study.

"Our patients, our families ask about, 'Well, are there health reasons to choose organic food in terms of nutritional content or human health outcomes?'"

To try to answer that question, she and her colleagues reviewed over 200 studies that compared either the health of people who ate organic or conventional foods or, more commonly, nutrient and contaminant levels in the foods themselves.

Those included organic and non-organic fruits, vegetables, grains, meat, poultry, eggs and milk.

Many of the studies didn't specify their standards for what constituted "organic" food - which can cost as much as twice what conventional food costs - the researchers wrote Monday in the Annals of Internal Medicine.

According to United States Department of Agriculture standards, organic farms have to avoid the use of synthetic pesticides and fertilizers, hormones and antibiotics. Organic livestock must also have access to pastures during grazing season.

Many conventional farms in the U.S., in contrast, use pesticides to ward off bugs and raise animals in crowded indoor conditions with antibiotics in their feed to promote growth and ward off disease. The Food and Drug Administration has been examining that type of antibiotic use and its contribution to drug-resistant disease in humans.

SAME VITAMINS

Smith-Spangler and her colleagues found there was no difference in the amount of vitamins in plant or animal products produced organically and conventionally - and the only nutrient difference was slightly more phosphorus in the organic products.

Organic milk and chicken may also contain more omega-3 fatty acids, they found - but that was based on only a few studies.

There were more significant differences by growing practice in the amount of pesticides and antibiotic-resistant bacteria in food.

More than one-third of conventional produce had detectable pesticide residues, compared to seven percent of organic produce samples. And organic chicken and pork was 33 percent less likely to carry bacteria resistant to three or more antibiotics than conventionally-produced meat.

Smith-Spangler told Reuters Health it was uncommon for either organic or conventional foods to exceed the allowable limits for pesticides, so it's unclear whether a difference in residues would have an effect on health.

But Chensheng Lu, who studies environmental health and exposure at the Harvard School of Public Health in Boston, said that while the jury is still out on those effects, people should consider pesticide exposure in their grocery-shopping decisions.

"If I was a smart consumer, I would choose food that has no pesticides," Lu, who wasn't involved in the new study, told Reuters Health. "I think that's the best way to protect your health."

He said more research is necessary to fully explore the potential health and safety differences between organic and conventional foods, and that it's "premature" to conclude organic meat and produce isn't any healthier than non-organic versions.

"Right now I think it's all based on anecdotal evidence," Lu said.

Sep 04
Soon, a 'brain map' that can measure pain intensity
So your kid often complains of stomach ache? You will soon be able to find out if it is just an excuse to skip school.

Scientists are developing a special 'pain map' of the brain which can help doctors measure the level and location of pain felt by patients.

Researchers from the University College London announced the development of a pain map which enables them to pinpoint the exact location and intensity of discomfort in the body, the Telegraph reported.

Using brain scanning technology, neuroscientists have been able to see how the brain responds to pain and map the signals to different parts of the body.

They have also been able to measure how much pain someone is in from the signals in the brain.

In the technique, different parts of the body light up specific areas of the brain when they are in pain.

Flavia Mancini, said it could change the way pain is diagnosed in patients and make it possible to quantify it objectively for the first time.

"When we used a laser to activate the pain receptors on the hand and fingers of our healthy subjects, we could see a signal very clearly in the brain. Other parts of the body will show up just as well," she said.

"The ways we quantify pain at the moment are unreliable and if a patient has difficulty communicating it can be very hard. In the future, we see this as a way to track pain in patients as there is a signal in the brain that correspondents to the current pain the person is experiencing," she was quoted as saying by the paper.

The findings were presented at the World Congress on Pain in Milan.

Sep 04
How diseases affect immune function
UCLA researchers have discovered a type of cell that is the "missing link" between bone marrow stem cells and all the cells of the human immune system.

The finding may help explain how a healthy immune system is produced and how disease can lead to poor immune function.

The studies were done using human bone marrow, which contains all the stem cells that produce blood during postnatal life.

The research team was "intrigued to find this particular bone marrow cell because it opens up a lot of new possibilities in terms of understanding how human immunity is produced from stem cells throughout life," said study senior author Dr. Gay Crooks, co-director of the Eli and Edythe Broad Center of Regenerative Medicine and a co-director of the Cancer and Stem Cell Biology program at UCLA's Jonsson Comprehensive Cancer Center.

Understanding the process of normal blood formation in human adults is a crucial step in shedding light on what goes wrong during the process that results in leukemia, or cancer of the blood.

Before this study, researchers had a fairly good idea of how to find and study the blood stem cells of the bone marrow. The stem cells live forever, reproduce themselves and give rise to all the cells of the blood. In the process, the stem cells divide and produce intermediate stages of development called progenitors, which make various blood lineages like red blood cells or platelets.

Crooks was most interested in the creation of the progenitors that form the entire immune system, which consists of many different cells called lymphocytes, each with a specialized function to fight infection.

"Like the stem cells, the progenitor cells are also very rare, so before we can study them we needed to find the needle in the haystack." said Lisa Kohn, a member of the UCLA Medical Scientist Training Program and first author in the paper.

Previous work had found a fairly mature type of lymphocyte progenitor with a limited ability to differentiate, but the new work describes a more primitive type of progenitor primed to produce the entire immune system, Kohn said

Once the lymphoid primed progenitor had been identified, Crooks and her team studied how gene expression changed during the earliest stages of its production from stem cells.

"The gene expression data convinced us that we had found a unique stage of development in the immune system. There was a set of genes that the lymphoid-primed cell shares with the bone marrow stem cells and a unique gene expression of its own once it becomes active. This data provided us with an understanding of what genes are important in creating all the cells of the immune system," said Crooks, a professor of pathology and pediatrics.

"The information could allow us to manipulate bone marrow to help create a stronger immune system," he noted.

The study appeared in the early online edition of Nature Immunology.

Sep 03
Book on breast cancer launched
Here's a chance for women to have every question about breast cancer answered, by just flipping a few pages. The book titled 'All About Breast Cancer' written by Dr Selvi Radhakrishna was released by Dr M K Mani and the first copy was received by Health Secretary Girija Vaidhyanathan.

Published by Macmillan, the book provides comprehensive and up-to-date information about breast cancer, which enables a patient to actively participate with doctors in the decision-making process. The book is meant for breast cancer patients.

The first-of-its-kind in India, this book is a complete guide, practical, educative, resourceful, empowering, comforting, informative, simple and clear.

"Medical treatment has become more expensive and is difficult for normal man to afford it. As medical practitioners, we lay less stress on prevention and early detection of the disease itself. Penn Nalam and a book like this written in simple readable English, is a great educator.

Translating this book into one language is not enough. It should be translated into every Indian language," Dr M K Mani said, congratulating Dr Selvi Radhakrishna.

"The way to go is to most importantly stop the spread of this disease. The government has been slow on this front. However, we are thankful to organisations like Penn Nalam who are doing extensive work in this field, so that we can partner and learn from them.

Cancer is on the government's agenda and will associate with Penn Nalam to reach out to the TN districts. We are setting up regional cancer centres in Madurai and Coimbatore.

As it is part of the CM's comprehensive health insurance scheme, we hope it will go a long way to treat cancer as well as prevent it," said Girija Vaidhyanathan.

Sep 03
Deep brain stimulation may help Parkinson's patients
Two studies by University of Alabama at Birmingham researchers have suggested that deep-brain stimulation (DBS) may stop uncontrollable shaking in patients with Parkinson's disease and essential tremor by imposing its own rhythm on the brain.

DBS uses an electrode implanted beneath the skin to deliver electrical pulses into the brain more than 100 times per second. Although this technology was approved by the Food and Drug Administration more than 15 years ago, it remains unclear how it reduces tremor and other symptoms of movement disorders.

With the help of electroencephalography or EEG - electrodes placed on the scalp - study authors used new techniques to suppress the electrical signal associated with the DBS electrode. That enabled the first clear, non-invasive EEG measurements of the underlying brain response during clinically effective, high-frequency brain stimulation in humans.

The results showed that nerves in the cerebral cortex, the outer layer of the brain, fire with rapid and precise timing in response to individual stimulus pulses. This suggests that DBS may synchronize the firing of nerve cells and break the abnormal rhythms associated with involuntary movements in Parkinson's disease and essential tremor.

The newly identified rhythm was captured during effective DBS treatment, so it could represent a new physiological measure of the stimulation dose, said the authors. If validated, such a yardstick could help to guide the fine-tuning of DBS stimulator settings in patients for more lasting relief, fewer side effects and less-frequent battery-replacement surgeries.

"Though it's clear that more work is needed to better understand these initial observations, we're very excited by our findings because they may provide a biological marker for improvement in the symptoms of these patients," said Harrison Walker, M.D., assistant professor in the UAB Department of Neurology's Division of Movement Disorders and lead author of the study.

In current clinical practice, stimulator settings are adjusted by trial and error, requiring careful observation of changes in symptoms over multiple clinic visits. But such immediate, visual feedback may not be available as DBS is applied to neurological or psychiatric conditions such as epilepsy, severe depression or obsessive compulsive disorder.

In these diseases, an effective dose measurement could be especially useful in optimizing DBS therapy.

In both studies, EEG data revealed that nerve cells in the cerebral cortex discharged about one one-thousandth of a second, or one millisecond, after each stimulus pulse was delivered into the brain.

The authors argue that this rapid response on the brain's surface most likely represented "backfiring" along extensions of cortical nerve cells called axons that connect them to deeper regions within the brain where the DBS electrodes were placed. Interestingly, this rapid response on the brain surface was present in both studies, regardless of the stimulation target or the disease state of the patient.

Although prior studies had hinted at these brain responses, they were unable to measure them directly because of interference from the competing electrical signal emitted by the DBS pulse itself. Walker and his team reversed the polarity of the stimulation pulse, in effect subtracting the DBS signal and leaving only the EEG signal associated with the brain activity.

The new technique also enabled the researchers to show that the size of the brain response at one millisecond after a DBS pulse is dependent on the intensity or voltage of the stimulus pulse, and that larger brain responses were closely associated with improvement in tremor.

"While early, this work has tremendous implications for the understanding of brain mechanisms responsible for a number of neurological and psychiatric diseases," said co-author Barton Guthrie, M.D., in the Division of Neurosurgery.

"Further studies are planned to confirm these measures and mechanisms and we believe this insight will soon make valuable contributions to the next generation of DBS treatments," he added.

The studies were published recently in the journal Movement Disorders.

Sep 01
Glass shape influences how quickly we down alcohol
How quickly you consume down an alcoholic drink may depend on the shape of the glass you're drinking from, a new study has suggested.

For the study, Dr Angela Attwood and colleagues from Bristol's School of Experimental Psychology recruited 160 social drinkers aged 18-40 with no history of alcoholism to attend two experimental sessions.


During one session they were asked to drink either lager or a non-alcoholic soft drink from either a straight-sided glass or a curved 'beer flute'.

They found that the participants were almost twice as slow when drinking alcohol from the straight-sided glass as compared to the curved glass.

However, there was no difference in drinking rates from the glasses when the drink was non-alcoholic.

The researchers suggest that the reason for this may be because it is more difficult to accurately judge the halfway point of shaped glasses. As a result, drinkers are less able to gauge how much they have consumed.

In order to test this, participants attended another session in which they completed a computer task that presented numerous pictures of the two glasses containing varying volumes of liquid.

By asking participants to judge whether the glass was more or less than half full, the researchers were able to show that there was greater error in accurately judging the halfway point of the curved glass.

Importantly, the degree of this error seemed to be associated with the speed of drinking the participants who tended to show the greatest error in their halfway judgments tended to show the greatest changes in drinking rate.

The speed at which an alcoholic beverage is drunk will influence the level of intoxication experienced, and also the number of drinks consumed in a single drinking session.

Therefore, slower drinking rates is likely to have positive impact on the individual and also at a population level.

"Due to the personal and societal harms associated with heavy bouts of drinking, there has been a lot of recent interest in alcohol control strategies. While many people drink alcohol responsibly, it is not difficult to have 'one too many' and become intoxicated. Because of the negative effects alcohol has on decision making and control of behaviour, this opens us up to a number of risks," Dr Attwood said.

"People often talk of 'pacing themselves' when drinking alcohol as a means of controlling levels of drunkenness, and I think the important point to take from our research is that the ability to pace effectively may be compromised when drinking from certain types of glasses," she added.

Sep 01
Kids with working mums at greater risk of obesity
Children whose mothers are in full-time employment are at greater risk of obesity even if their father is a stay-at-home parent, according to experts.

Their study highlights that men about the house fail to realise the importance of their child's eating habits.

Study authors say that it is important for both parents to discuss day-to-day responsibilities, including food preparation and mealtimes.

John Cawley, from Cornell University and Feng Liu used data on almost 25,000 families from a yearly survey of how Americans spend their time.

Data showed that on average women who worked spent 127 fewer minutes per day with their children than stay-at-home mothers.

However stay-at-home fathers failed to offset the difference "We're not trying to say men are scum," Cawley told BuzzFeed.

Cawley and Liu noted that preparing meals from scratch and eating as a family could decrease a child's risk of obesity.

They also suggest that schools could offer healthier food and better physical education.

The study is published in the June issue of Economics and Human Biology.

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