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Nov 02
Fight Dementia with everyday drugs
Everyday medicines like antibiotics, acne pills and other routine treatments that are already in bathroom cabinets could be used in the battle against dementia as developing new drugs is too costly and slow, experts have suggested.

According to experts, it is time to re-examine medicines already in circulation as cheaper, quicker alternatives to new treatments.

Many have multiple effects on the body, so some could be able to ease the effects of Alzheimer's and other forms of dementia.

There are only four Alzheimer's drugs in use which can help relieve symptoms but do nothing to stop damage to the brain.

"Defeating dementia is one of the biggest challenges facing both medicine and society as a whole," the Daily Mail quoted Professor Clive Ballard as saying.

"Developing new drugs is incredibly important but it comes with a huge price tag and, for those affected by dementia, an unimaginable wait," Ballard said.

It can take up to 20 years and 600 million pounds to create a drug from scratch. Hopes of quickly adding to available treatments were recently dashed when several promising new ones failed the final stage of testing.

So Mr Ballard, professor of age-related diseases at King's College London, and other experts turned to the possibility of using everyday drugs.

They drew up a short-list, which includes liraglutide - a diabetes treatment that also acts on the brain.

Others include minocycline, an antibiotic for acne, and acitretin, which treats the skin condition psoriasis. There is also a family of blood pressure drugs called calcium channel blockers.

Some of these medicines cost less than 50p a tablet.
"The idea that drugs for other conditions could fight Alzheimer's is appealing," Rebecca Wood, chief executive of Alzheimer's Research UK, said.

"But it's not yet clear that such a drug exists. Alzheimer's is a complex disease with many risk factors," Wood added.

The study has been published in the journal Nature Reviews Drug Discovery.

Nov 02
Is junk food the cause of puberty at 6?
Some girls are only six or seven when they have to cope with their first period.

And a US study has found that boys are also hitting physical maturity up to two years earlier than in the past.

Scientists found that the average age for the onset of puberty in girls in 1860 was 16.6 years.

By 1920 it was 14.6, in 1950, 13.1, in 1980, 12.5 and in 2010 it had dropped to 10.5.

Experts fear this could lead to an increase in young girls getting pregnant.

Marcia Herman-Giddens, from the University of North Carolina where the latest research was carried out, claims obesity may well to be blame as it alters the body's hormones - with some starting to show the first signs of maturity as young as six.

The average age for white and Hispanic boys is ten, while it is nine for black boys.

Tam Fry, honorary chairman of the UK's Child Growth Foundation, has described this as a "ticking timebomb" for today's society.

PUBERTY is the process of body changes from the first signs of adolescence to full adult development.

It is brought about by a series of chemical signals, which are sent from the brain to the pituitary gland in the head, then from the pituitary to the sex glands, the ovaries in girls and the testicles in boys.

These in turn make the sex hormones oestrogen in girls and testosterone in boys, which cause the physical changes of puberty.

Normal puberty takes from four to five years in both sexes but it starts earlier in girls than in boys.

Nov 01
Just one junk food meal can up heart attack risk
Eating even a single junk food meal can be enough to raise the risk of suffering a heart attack, cardiovascular disease or stroke in later life, new study led by an Indian-origin researcher has warned.

Experts at the EPIC Centre of Canada's Montreal Heart Institute, affiliated to the University of Montreal, say the key to staving off heart disease and other illnesses caused by clogged arteries is to switch to a Mediterranean-style diet, based on healthy foods like oily fish, fresh vegetables and olive oil, the Daily Express reported.


Dr Anil Nigam, director of research at EPIC and associate professor at the university's Faculty of Medicine compared the effects of junk food and a typical Mediterranean meal on the ability of arteries to dilate after a temporary five-minute blockage.

The research looked at 28 nonsmoking men, who ate a Mediterranean-type meal first and then a junk food-type meal one week later.

After the Mediterrean-style meal the men's arteries were found to dilate normally and maintain good blood flow.

But after eating the junk food the arteries of the study participants dilated 24 per cent less than they did when in a fasting state.

The findings were presented at the Canadian Cardiovascular Congress.

Nov 01
Anti-bird flu warriors grope in the dark
The confirmation of avian influenza among the birds housed at Central Poultry Development Organisation & Training Institute (CPDOTI) in Hesaraghatta near here has only worsened the situation, with fears of it leading to a further outbreak among birds and in a more scary scenario among humans too.

This is because while confirming that the samples of chickens, ducks and emus had tested positive for avian influenza, the scientists at the High Security Animal Disease Laboratory (HSADL) in Bhopal have not been able to identify precisely whether the virus infecting the CPDOTI birds is a mutation or not. Nor have they been able to determine how rapidly this virus can infect humans, or even the pace of disease spread among birds.

The situation is scary because as per scientists at HSADL who preferred to remain anonymous, a year ago a dangerous mutation of the H5N1 virus (the virus that causes avian flu) had occurred in July-August 2011.

There are three series type of viruses that cause avian flu -- H5, H7 and H9. Of these H5 is the most infectious, and known to have caused deaths among humans too.

The H5N1 virus with the mutation, identified only as H5N1-2.3.2.1, was detected in North and Central Vietnam. Last year, a chief veterinary officer of Food and Agricultural Organisation, had identified poultry sector in India among those of neighbouring nations to be at extreme risk of being hit by this mutant virus.

No one in Bangalore or at HSADL in Bhopal know for sure whether the infecting virus now is the basic H5N1 virus, the deadly mutated H5N1-2.3.2.1 virus, or a deadlier mutation than that.

What is further worrying is this: The possibility of it being a mutant would mean that a range of antibodies used for developing human vaccines (in case required) would be rendered useless. This, because most human vaccines for H5N1 virus have been derived from 2004 strains of the virus, much before the deadly mutations were recorded.

The experts also point to another worrying scenario. The H5N1-2.3.2.1 virus was found to become more and more dominant with such vaccines against it -- a role-reversal compared to vaccines formed with weaker germs strengthening blood cells that fight them.

CPDOTI scientists are tight-lipped about how they are planning to deal with the situation. However, experts at HSADL said they would be groping in the dark and only make matters worse if they had to try and tackle the virus with the existing vaccines. "And it could turn disastrous if the virus that has attacked the birds now is a further mutated one," said one of the scientists.

For now, preventive and precautionary measures seem the only hope for Bangalore -- and for that matter, Karnataka and entire India.

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