People are better off not having a spouse than having poor relationship with one, a new study by U-M researchers has found.

After analyzing data from nearly 5,000 American adults, the researchers found that the quality of a person`s relationships with a spouse, family and friends predicted the likelihood of major depression disorder in the future, regardless of how frequently their social interactions took place.

Individuals with strained and unsupportive spouses were significantly more likely to develop depression, whereas those without a spouse were at no increased risk. And those with the lowest quality relationships had more than double the risk of depression than those with the best relationships.

The study assessed the quality of social relationships on depression over a 10-year period, and is one of the first to examine the issue in a large, broad population over such a long time period.

Nearly 16 percent of Americans experience major depression disorder at some point in their lives, and the condition can increase the risk for and worsen conditions like coronary artery disease, stroke and cancer.

"Our study shows that the quality of social relationships is a significant risk factor for major depression," said psychiatrist Alan Teo, M.D., M.S., a Robert Wood Johnson Foundation Clinical Scholar at U-M and the study`s lead author.

Digging deeper into the results, the researchers found that certain positive and negative aspects of relationships also predicted depression. Social strain and a lack of support - especially in spousal relationships and to some extent with family members - were both risk factors for developing depression later.

"These results tell us that health care providers need to remember that patients` relationships with their loved ones likely play a central role in their medical care," Teo said.

"They also suggest that the broader use of couples therapy might be considered, both as a treatment for depression and as a preventative measure," he added.

While the results confirmed the researchers` assumptions about relationship quality, they did not find a correlation between the frequency of social interactions and the prevalence of depression as predicted. Even if participants were socially isolated, having few interactions with family and friends, it did not predict depression risk. Teo said that this finding should also translate to mental health treatment considerations.

"Asking a patient how she rates her relationship with her husband, rather than simply asking whether she has one, should be a priority," Teo stated.

The study was published online in PLOS ONE.