Scientists find new way to fix a broken heart
Posted on Friday, 24th July 2009
A new way to mend damage to the heart has been found by scientists.
The boffins have devised a method to coax heart muscle cells into re-entering the cell cycle, allowing the differentiated adult cells to divide and regenerate healthy heart tissue after a heart attack, according to studies in mice and rats by Children's Hospital Boston reported in the July 24th issue of the journal Cell.
If the same mechanisms identified by the researchers can be shown to work in the human heart, it opens up real possibilities for new and more efficient ways to treat people with heart disease, reports The BBC.
Theoretically, it could be used to treat heart attack patients, those with heart failure and children with congenital heart defects.
The key ingredient is a growth factor known as neuregulin1 (NRG1).
Previously, it was believed that the heart was incapable of repairing itself. During prenatal development, heart muscle cells (cardiomyocytes) proliferate but were thought to lose that ability shortly after birth. But, recent research has indicated that the adult cells do have some ability to replace themselves at a low level.