The repetitive anaesthesia with isoflurane, given by inhalation, can increase the risk of developing alzheimer's Disease (AD) in the patients with the genetic risk factors for the disease, says the study.

The studies conducted in the mice proved that anaesthesia is safe for the normal ones, but potentially harmful for the mice with the mutations of the amyloid Precursor Protein (APP). This finding suggests a possible mechanism of developing Alzheimer.


Some epidemiological studies have shown an increased prevalence of AD, in patients undergoing anaesthesia and surgery. So it will be ideal to know the genetic background of the patients, as the pattern of the drugs can be used accordingly, says the experts.

The repetitive anaesthesia can also increase the mortality risks in the patients who have the genetical risks. There is a chance for the patients to show less reactivity, when the dose of anaesthesia is over. The time for recovery after anaesthesia, also can be increased.

The repetitive anaesthesia can also produce persistent disorders in such people, which affect their behaviour later, says the scientists.